Báo cáo khoa học: Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis docx

... inducing release of cytochrome c; (b) directly and/ or indirectly cause enhanced formation of mitochondrial ROS (and further oxidant- induced lysosomal destabiliza- tion); (c) activate lytic pro -enzymes, ... mitochondrial ROS production, release of cytochrome c, and activation of PLA2 (all of which may promote the apoptotic cascade), we tested the effects of two ly...

Ngày tải lên: 31/03/2014, 07:20

... donald.hilvert@org.chem.ethz.ch Abbreviations:BsCM,Bacillus subtilis CM; CM, chorismate mutase; EcCM, Escherichia coli CM; MjCM, Methanococcus jannaschii CM; MLE II, muconate lactonizing enzyme II; OSBS, ortho- succinylbenzoate; ... existing enzyme scaffold with a completely new activity, changing both substrate specificity and chemical mechanism? Binary patterning [17] and restricted amin...

Ngày tải lên: 19/02/2014, 12:20

... the proper place for describing discourse markers is a dedicated lexicon that provides a classification of their syntactic, semantic and pragmatic features and characterizes the relationships ... specific, some markers can signal quite dif- ferent relations; e.g., while can be used for TEMPORAL CO-OCCURRENCE, and also for CONTRAST. Accordingly, we propose that the proper place...

Ngày tải lên: 20/02/2014, 18:20

... substrate Heme handling/ligation System I System II CcmE CcmF ResA ResB ResC CcdA CcmH CcmG DsbD D CcmB CcmA CcmC p-side p-side Disulfide isomerization Fig. 1. Schematic representation of cytochrome c biogenesis ... haem-attachment and signal-cleavage sites for Paracoccus denitrificans cytochrome c5 50 probes path- way of c- type cytochrome biogenesis in Escherichia coli. Mol Micro...

Ngày tải lên: 06/03/2014, 09:22

... character in a multi-character word I intermediate character in a multi- character word (for words longer than two characters) E last character in a multi-character word Character types can also ... by hand. Since the introduction of statis- tical techniques in NLP, research has been done on Chinese unknown word detection using such tech- niques, and the results showed that statistical base...

Ngày tải lên: 17/03/2014, 06:20

... of carbinol-amides. Under acidic conditions, a cationic mechanism in which the first step corresponds to the protonation of carbinol-amines or carbinol-amides has been consid- ered. Because the carbinol-amines and carbinol-amides modeled ... elimination reaction. Based on reaction conditions, three types of mechanism can be consid- ered: neutral, cationic and anionic. Because highly basic...

Ngày tải lên: 22/03/2014, 16:20

... galactolipid molecular species were separated by RP-HPLC. Compounds 1 and 2 were collected and finally purified by cyanopropyl-phase HPLC for further structural elucidation. Identification of compound ... subjected to GC-MS analysis. Two products were detected, namely the methyl esters of a-linolenic acid and (x5Z)-etherolenic acid. The electron impact mass spectrum of (x5Z)-etherolenic ac...

Ngày tải lên: 23/03/2014, 05:22

... Proceedings of the 12th Conference of the European Chapter of the ACL, pages 835–842, Athens, Greece, 30 March – 3 April 2009. c 2009 Association for Computational Linguistics Growing ... ,!61D ,!AA:B*A<B <,1! * We replicate the above experiments using the same 402 noun...

Ngày tải lên: 24/03/2014, 03:20

... and b-actin (forward primer, 5¢-GCTGTCCCTGTATGCCTCTG-3¢, and reverse primer, 5¢-CGCTCGTTGCCAATAGTGA TG-3¢) were designed using the beacon designer software (Premier Biosoft Int., Palo Alto, CA, ... particularly important in the regulation of cardiac function [10]. It is involved in vascular and nonvascular effects, including regulation of cardiomyo- cyte contractility, in which mitocho...

Ngày tải lên: 19/02/2014, 00:20

... pathways and accumulation of biologically active molecules [e.g. long-chain acyl-CoAs (LCACs), ceramide, diacylglyc- erol] could adversely affect cellular function by direct effects on a variety of enzymes ... in the case of succinate oxidation); 2, QH 2 -oxidizing module, comprising cytochrome bc 1 and cytochrome c oxidase; 3, proton leak module, comprising passive membrane perme...

Ngày tải lên: 19/02/2014, 05:20