Báo cáo khoa học: A functional polymorphism at the transcriptional initiation site in b2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of b2-glycoprotein I docx

... new polymorphism at the transcriptional initiation site of the b 2 GPI gene that is associated with less binding with a putative transcriptional factor, lower gene expression, lower b 2 GPI plasma ... DHPLC and identi- fied a point mutation at the transcriptional initiation site ()1C A) with a carrier frequency of 12.1%. The mutation w...

Ngày tải lên: 31/03/2014, 07:20

... structure and activates plasma lysolecithin acyltransferase. It is also able to modulate the interaction of apolipoprotein E with b-migrating VLDLs and inhibit binding of b-VLDL to low-density lipoprotein ... give peaks of unequal intensity because of unequal rates of biosynthesis, utilization, or degradation. Variants of TTr that are associated with pathophysiology...

Ngày tải lên: 19/02/2014, 05:20

... whose applicative bracketing is given in ( 6a) . (6) [this is the dog][that bit the cat] [that chased the raft[that ( 6a) [this[is [the[ dog[that[bit [the[ cat [that[chased [the[ rat[that THE PHONETICS ... trees are fixed in depth and n-ary branching. Acceding to Selkirk and Tateishi (S&T, 1989) the syntax-prosody mapping is then defined by associating with ea...

Ngày tải lên: 09/03/2014, 01:20

... information characterization 3. decomposition 4, linking (identification of related information) 5. mapping Some inquiries determine whether information of a certain character is available, ... available informaion is decomposable into parts in a syntactically significant way (usually through information availability inquiries), information decomposition inquiries are us...

Ngày tải lên: 24/03/2014, 05:21

... information to be used in the translation of the remaining pieces of the L-Spec. In addition to the grammar routines, as the initial tree is traversed at each place where new information could ... their generator. Notice that the methodology described always starts gen- erating from an initial tree and other auxiliary or initial trees are adjoined or substituted...

Ngày tải lên: 31/03/2014, 06:20

... glyco-alteration in candidate glycoproteins to determine clinical utility After the identification of numerous candidate glyco- proteins with cancer -associated glyco-alterations, it was necessary ... functional analysis of glycosylation associated with diseases. Armed with our knowledge of human glycosylation, glycan structural analysis systems, the bioinformatics capab...

Ngày tải lên: 16/02/2014, 08:20

... The similarity of the C-terminal domain of MABO to other proteins of the sarcosine dehydrogen ase and oxidase family may indicate that this is the site of attachment of tetra- hydrofolate to the enzyme. ... the MABO gene The amino acid substitutions in the MABO protein were made with the aid of the Quick Change site- directed mutagenesis kit (Stratag...

Ngày tải lên: 19/02/2014, 16:20

... methionine and threonine biosynthesis pathways in Arabidopsis thaliana (Fig. 1). The computer model was validated in vitro andusedtoexamine the branch-point kinetics in detail and to obtain insights ... cysteine via a ping-pong mechanism. Reactions are irreversible and inhibited by inorganic phosphate. The modelling procedure included an examination of the kinetic link...

Ngày tải lên: 20/02/2014, 02:21

... this is a rather simple task. We decided to use the hierarchical clustering algorithm readily available in the MATLAB (MATrix LABoratory) programming language. After some testing with various ... matrix. An appropriate algebraic method that has the capability to reduce the dimen- sionality of a rectangular or square matrix in an optimal way is singular value decompos...

Ngày tải lên: 20/02/2014, 16:20

... representation of spatial predications that they must capable of being easily combined, to give rise to a cumulative meaning. COGNITIVE GRAMMAR AND LINGUISTIC MEANING Cognitive granlmar is comprised ... of an ideational view of linguistic meaning which, it seems, is an anathema to computational lin- guists. In this paper we take a serious, if infor- mal, look at Ron...

Ngày tải lên: 20/02/2014, 21:20