... mayundergo conformational changes, thereby affecting the downstream regulation of protein–protein interactions,cellular signal transduction and transcription of DNA[4–7]. Conformational transition, ... cholerae. Based on the thermodynamicparameters of binding one can speculate on the nature of the interaction between ToxRp and ZnO NPs, and the consequent effect on protein conformation. The NP-treated ... NPs. The predominant contribution of elec-trostatic interactions, along with van der Waalsinteractions, rather than hydrophobic interactions, ismanifested as the higher contribution of enthalpy,compared...