... Department of Biology and Biochemistry, University of Bath, UK2 Department of Biochemistry, University of Wisconsin–Madison, USA3 Department of Chemistry, University of Wisconsin–Madison, USAIntroductionUpon ... studies of the structure and binding sites of enzymes. 8. Inhibitor binding toribonucleases. J Mol Biol 45, 491–511.33 Ui N (1971) Isoelectric points and conformation of proteins. I. Effect of urea ... X-ray data collection and refinement statistics. Rsymm= RhRi|I(h) ) Ii(h)| ⁄ RhRiIi(h), where Ii(h) and I(h) are the ith and the meanmeasurements of the intensity of reflection h, respectively....