Báo cáo khoa học: "Memory-Efficient and Thread-Safe Quasi-Destructive Graph Unification" pptx

... with a strand of siRNA, and the other siRNA strand was subsequently annealed to the aptamer-conjugated strand. These aptamer–siRNA conjugates were able to access HIV- infected cells and silence ... Elbashir SM, Vandenburgh K, Manninga H, Scaringe SA, Weber K & Tuschl T (2003) Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the ef...

Ngày tải lên: 06/03/2014, 01:23

... machine learning and a cascaded finite-state parser with a hand-crafted grammar. It dis- cusses several ways to combine them and presents evaluation results for the two in- dividual approaches and their ... especially rewarding to combine deep and shallow systems, where the for- mer guarantees interpretability and high precision and the latter provides robustness and high recall....

Ngày tải lên: 17/03/2014, 06:20

... sig- nalling [3–5] and of cytokines such as interleukin (IL)-6 [6]. It is also involved in transformation and tumour progression [7] and its activation, as detected in breast, head and neck, lung and colon ... control ODN (con) and the dead cells were counted after 16, 24 and 48 h of culture using trypan blue staining. (C) Cells were treated with 0.5, 1 and 2 lg of hpST3dODN...

Ngày tải lên: 18/02/2014, 08:20

... diagnostic and therapeutic schemes. Antisense-RNA, ribozyme, aptamer and siRNA tech- nologies have been developed and have found applica- tion in molecular medicine [1–7]. Signalling aptamers and aptazymes ... as three additional bands (lanes 3 and 4). These signals correspond to the 29- and 35-mer resulting from ligation of the 20-mer to either the 9- or 15-mer cleavage product,...

Ngày tải lên: 20/02/2014, 01:20

... occurs via proteolytic cleavage of APP by a-andc-secretases and results in release of nontoxic soluble a-APP(s) protein and two other shorter products P3 and C7 [2,3]. In normal healthy individuals these ... electrophoresis and stained with ethidium bromide. For experiments performed in co- amplification conditions two pairs of primers P1 BACE and P2 BACE ,forBACEmRNA(20l M ), and...

Ngày tải lên: 08/03/2014, 08:20

... a-carbon virtual-bond backbone is displayed as a red line and the yellow and gray spheres indicate a-carbons, respectively, associated with overexposed (under 33% buried) and buried hydrophobic residues. Significantly, ... [7,8]. Insufficiently desolvated HBs and the PrP C fiPrP Sc transition Consistent withresults reported previously [7,8], the a-helix 1 is the most susceptible to struc...

Ngày tải lên: 08/03/2014, 10:20

... leaves were inoculated with TMV alone, TMV and scrambled dsDNA (384 bp), TMV and siDNA, and TMV and dsRNA (280 bp). Symptoms of infection are shown. (E) Graph showing the amounts of necrotic symptoms ... hybridization of sense strand (5¢-GTTGCTCTGGAAAACTCATTT-3¢) and anti- sense strand (5¢-ATGAGTTTTCCAGAGCAACTT-3¢), and siRNA was synthesized using DNA templates (sense strand, 5¢...

Ngày tải lên: 16/03/2014, 02:20

... sonication conditions. Results and Discussion Effect of EDTA and digitonin on PMCA Prior to starting PMCA, we confirmed the presence of PrP Sc in mBSE-brain homogenate (BH) and Chandler- BH by western ... used as standards for the dot-blot analysis. Linear regression between dot intensities (arbitrary units) and rMoPrP is shown (n = 3, average ± SD, r 2 = 0.967). (C) NBH, mBSE-BH and...

Ngày tải lên: 23/03/2014, 04:21

... Training and Minimum Bayes-Risk Decoding for Translation Hypergraphs and Lattices Shankar Kumar 1 and Wolfgang Macherey 1 and Chris Dyer 2 and Franz Och 1 1 Google Inc. 1600 Amphitheatre Pkwy. Mountain ... approximated log(BLEU) score by a linear function of n-gram matches and candidate length. If E and E  are the reference and the candidate translations respec- tively, this...

Ngày tải lên: 23/03/2014, 16:21

... that contain A and at least one additional bidirectional arc. For example, suppose the corpus contains the text fragments ‘book and newspaper’, ‘newspaper and book’, ‘book and note’, ‘note and book’ and ‘note ... space and use similarity measures and automatic clustering in that space (Curran and Moens, 2002). Pereira (1993) and Lin (1998) use syntactic features in the vec...

Ngày tải lên: 23/03/2014, 18:20