Báo cáo khoa học: "Memory-Efficient and Thread-Safe Quasi-Destructive Graph Unification" pptx
Báo cáo khoa học: Efficient and targeted delivery of siRNA in vivo pdf
... with a strand of siRNA, and the other siRNA strand was subsequentlyannealed to the aptamer-conjugated strand. Theseaptamer–siRNA conjugates were able to access HIV-infected cells and silence ... Elbashir SM, Vandenburgh K,Manninga H, Scaringe SA, Weber K & Tuschl T(2003) Sequence, chemical, and structural variation ofsmall interfering RNAs and short hairpin RNAs and the effect ... and offer highstructural and functional tunability. An ideally designednonviral siRNA carrier with its desirable structural and functional multicomponents is depicted in Fig. 2.Liposomes and...
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Báo cáo khoa học: "Combining Deep and Shallow Approaches in Parsing German" pptx
... machinelearning and a cascaded finite-state parserwith a hand-crafted grammar. It dis-cusses several ways to combine them and presents evaluation results for the two in-dividual approaches and their ... especially rewarding tocombine deep and shallow systems, where the for-mer guarantees interpretability and high precision and the latter provides robustness and high recall.This paper investigates ... consist-ing of an n-gram based shallow parser and a cas-caded finite-state parser1with hand-crafted gram-mar and morphological checking. The respectivestrengths and weaknesses of these approaches arebrought...
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Tài liệu Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf
... sig-nalling [3–5] and of cytokines such as interleukin (IL)-6[6]. It is also involved in transformation and tumourprogression [7] and its activation, as detected in breast,head and neck, lung and colon ... control ODN (con) and the dead cells were counted after 16, 24 and 48 h of culture using trypan blue staining. (C) Cells weretreated with 0.5, 1 and 2 lg of hpST3dODN and 1 and 2 lg of control ... (lanes 4 and 5) for 16 h and lysed; the complexes were bound to streptavidine and separatedon gels. Cells were either not treated (lane 1), treated with IL-6(30 ngÆmL)1, lanes 2 and 4) or...
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Tài liệu Báo cáo khoa học: Efficient RNA ligation by reverse-joined hairpin ribozymes and engineering of twin ribozymes consisting of conventional and reverse-joined hairpin ribozyme units ppt
... diagnostic and therapeutic schemes.Antisense-RNA, ribozyme, aptamer and siRNA tech-nologies have been developed and have found applica-tion in molecular medicine [1–7]. Signalling aptamers and aptazymes ... as three additionalbands (lanes 3 and 4). These signals correspond to the29- and 35-mer resulting from ligation of the 20-merto either the 9- or 15-mer cleavage product, and to thedesired product ... Cy5)] and 15-mer [35-mer (F5, Cy5)], respectively, and to final44-mer RNA product labelled with Cy5 and two fluo-rescein moieties [44-mer (F3, F5, Cy5)].In both experiments (compare Figs 4B and...
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Báo cáo khoa học: Efficient inhibition of b-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes doc
... occurs via proteolyticcleavage of APP by a-andc-secretases and results in releaseof nontoxic soluble a-APP(s) protein and two other shorterproducts P3 and C7 [2,3]. In normal healthy individualsthese ... electrophoresis and stainedwith ethidium bromide. For experiments performed in co-amplification conditions two pairs of primers P1BACE and P2BACE,forBACEmRNA(20lM), and P1GAPDH and P2GAPDH, ... transcription and PCR amplification of Rz-1 and Rz-2 plasmids with specific vector primers P1 and P2 (see Materials and methods) were obtained (lanes 2 and 4, respectively). When RT/PCR was performed...
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Báo cáo khoa học: Insufficient hydrogen-bond desolvation and prion-related disease ppt
... a-carbonvirtual-bond backbone is displayed as a red line and theyellow and gray spheres indicate a-carbons, respectively,associated with overexposed (under 33% buried) and buriedhydrophobic residues. Significantly, ... [7,8].Insufficiently desolvated HBs and the PrPCfiPrPSctransitionConsistent withresults reported previously [7,8], the a-helix 1is the most susceptible to structural change into b-strand and condensation onto ... paired by UDHBs, and thus, their engagement inbinding is triggered by the possibility of providing furtherdesolvation to the UDHBs. On the other hand, hydropho-bic residues 138, 139 and 141, if...
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Báo cáo khoa học: A new and efficient method for inhibition of RNA viruses by DNA interference pptx
... leaves were inoculated with TMV alone, TMV and scrambled dsDNA(384 bp), TMV and siDNA, and TMV and dsRNA (280 bp). Symptoms of infection are shown. (E) Graph showing the amounts of necroticsymptoms ... hybridization of sensestrand (5¢-GTTGCTCTGGAAAACTCATTT-3¢) and anti-sense strand (5¢-ATGAGTTTTCCAGAGCAACTT-3¢), and siRNA was synthesized using DNA templates (sense strand,5¢-AAATGAGTTTTCCAGAGCAACCCTGTCTC-3¢; ... with TMV and either 22 nucleotide sense strand DNA, 20 nucleotide antisensestrand DNA, 470 bp dsDNA, or siRNA. Tobacco leaves with symptoms of TMV infection are shown. Uninfected plants and plants...
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Báo cáo khoa học: Hyperefficient PrPSc amplification of mouse-adapted BSE and scrapie strain by protein misfolding cyclic amplification technique pptx
... sonication conditions.Results and DiscussionEffect of EDTA and digitonin on PMCAPrior to starting PMCA, we confirmed the presence ofPrPScin mBSE-brain homogenate (BH) and Chandler-BH by western ... used as standards for the dot-blotanalysis. Linear regression between dot intensities (arbitrary units) and rMoPrP is shown (n = 3, average ± SD, r2= 0.967). (C) NBH,mBSE-BH and Chandler-BH ... Divalentmetal ions, in particular copper and zinc, are knownto inhibit conversion to PrPSc[21] and fibril formationin recombinant PrP [22], and EDTA and imidazole arepresumed to minimize the...
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Báo cáo khoa học: "Efficient Minimum Error Rate Training and Minimum Bayes-Risk Decoding for Translation Hypergraphs and Lattices" pptx
... Training and Minimum Bayes-Risk Decoding forTranslation Hypergraphs and LatticesShankar Kumar1 and Wolfgang Macherey1 and Chris Dyer2 and Franz Och11Google Inc.1600 Amphitheatre Pkwy.Mountain ... approximatedlog(BLEU) score by a linear function of n-grammatches and candidate length. If E and Eare thereference and the candidate translations respec-tively, this linear function is given ... sourcevertex. The arity of a hypergraph is the maximumarity of its hyperedges. A hyperedge of arity 1 is aregular edge, and a hypergraph of arity 1 is a regu-lar graph (lattice). Each hyperedge...
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Báo cáo khoa học: "Efficient Unsupervised Discovery of Word Categories Using Symmetric Patterns and High Frequency Words" ppt
... thatcontain A and at least one additional bidirectionalarc. For example, suppose the corpus contains thetext fragments ‘book and newspaper’, ‘newspaper and book’, ‘book and note’, ‘note and book’ and ‘note ... space and use similarity measures and automatic clusteringin that space (Curran and Moens, 2002). Pereira(1993) and Lin (1998) use syntactic features in thevector definition. (Pantel and Lin, ... two CWs; and (2) x precedes y in P. Denoteby Nodes(G), Arcs(G) the nodes and arcs in a graph G, respectively.We now compute three measures on G(P ) and combine them for all pattern candidates...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ