... VE-cadherin at the cell borders (C). EC mechanosensing of the underlying substrate is probably completedvia integrin binding at FAs, leading to stretching of talin and activation of vinculin to reinforce ... afibronectin molecule, and the maintenance of this bondrequires talin, which binds the integrin to an actin fila-ment [16]. Stretching talin activates vinculin, a FA pro-tein, leading to reinforcement ... EC is in the direction of shear stress. In (C), the force is in the direction of tension of actin filaments, maintained with the help of neighboring cells in contact. In (D), the force is in the...