Báo cáo khoa học: Calcium and polyamine regulated calcium-sensing receptors in cardiac tissues doc

... Calcium and polyamine regulated calcium- sensing receptors in cardiac tissues Rui Wang 1 , Changqing Xu 2 , Weimin Zhao 1 , Jing Zhang 1 , Kun Cao 1 , Baofeng Yang 2 and Lingyun Wu 3 1 Department ... changes in [Ca 2+ ] o in the vicinity of cardiomyocytes [1]. The naturally occurring polyamines, including spermine, spermidine and putrescine, are involved in the synt...

Ngày tải lên: 31/03/2014, 01:20

... messen- gers [protein kinase C (PKC) and cAMP] [26]; (b) receptor-interacting proteins such as Src and b-zarrestin [53,75]; and (c) upstream kinases such as MAPK ⁄ ERK kinase and PI3K [53,76]. ... protein kinase; MMP, matrix metalloproteinase; NF-jB, nuclear factor kappa B; PI3K, phosphatidylinositol 3-kinase; PKC, protein kinase C; Pyk2, proline-rich tyrosine kinase 2; RTK, receptor...

Ngày tải lên: 16/03/2014, 04:20

... acetylcholine muscarinic recep- tors as well as cholecystokinin A receptors, whereas NAADP increased only through the activation of chol- ecystokinin A. Intriguingly, the striking difference seen in ... Ca 2+ stores, resulting in the inhibition of InsP 3 and cADPR responses. However, NAADP- induced Ca 2+ release remains [21]. Similar results were seen in intact sea urchin eggs when p...

Ngày tải lên: 20/02/2014, 01:20

... findings (Section 3.3), we divided the training (TREC) data in 9 bins of increasing size (200 instances between two con- tiguous bins) and we measured the learning and test time 5 for each bin. ... features. In this per- spective, String Kernel (SK) proposed in (Shawe- Taylor and Cristianini, 2004) and the Syntactic Tree Kernel (STK) (Collins and Duffy, 2002) al- low for modeli...

Ngày tải lên: 22/02/2014, 02:20

... proteins were also detected in the high-density caveolae. In response to insulin, the insulin receptor autophosphorylation and the amount of insulin -regulated glucose transporter-4 increased in these ... after charring in perchloric acid, according to Fiske and Subar- row [39] and modified as in Svennerholm and Vanier [40]. Protein determination Protein was quantitated usin...

Ngày tải lên: 16/03/2014, 13:20

... random, and split them into 40 verbs for training and 10 for testing (yielding 13,146 occurrences for training and 2,723 occurrences for testing; see Table 4). The results obtained after training ... tagging first PropBank roles and mapping into Verb- Net roles is as effective as training and tagging directly on VerbNet, and more robust for do- main shifts. 1 Introduction Semantic...

Ngày tải lên: 17/03/2014, 02:20

... added up, and the cosine between the resulting win- dow vectors is assigned to the gap between the win- dows in the text. High values indicate lexical close- ness. Troughs in the resulting similarity'curve ... adjacent windows (200 words each in this experiment) move over the input text, and at pre-determined intervals (every 10 words), the vec- tors associated with the...

Ngày tải lên: 17/03/2014, 07:20

... characteristics in RA patho- genesis [1]. FLSs play a key role in the development of sustained in ammation and angiogenesis in arthritic joints [2–4]. Several cytokines and RA factors existing in the ... in less severe disease and reduces cytokine levels in tissue in vivo [8]. In RA synovium, FLSs express both tumor necrosis factor-a (TNF-a) and Fas receptors, and...

Ngày tải lên: 23/03/2014, 07:20

... observed. Fig. 2. Main activity and interactions of GS upstream and intron modules in FTO-2B hepatoma and C2/7 muscle cells. Main activities and interactions (±95% confidence interval) were calculated ... the minimal promoter and minimized first intron. Panels III and IV show activities of combinations of upstream enhancer and the entire upstream region, respectively, in conju...

Ngày tải lên: 23/03/2014, 20:22

... can initi- ate a caspase cascade upon binding of ligands such as Fas ligand, TNF-a or TNF-related apoptosis-inducing ligand [3]. Although caspases play a crucial role in cell death, increasing ... signal -regulated kinases 1 and 2 (ERK1 ⁄ 2), the c-JunNH 2 -terminal kin- ases (JNK) and the p38 kinases. There is a widely accepted perception that JNK⁄ SAPK (stress-activated protein kinas...

Ngày tải lên: 29/03/2014, 08:20