... thiol, and functional amino and carboxylategroups [11–13]. Another way for RNA to increase itschemical diversity would be to bind exogenous mole-cules carrying reactive groups and handle them ... when the two cofactors were addedtogether. This indicates that both adenine and Mg2+must be present for the reaction to occur, and that theorder of addition of the two cofactors does not signifi-cantly ... Springer-Verlag, Berlin.13 Kun A, Maurel MC, Santos M & Szathmary E (2005)Fitness landscapes, error thresholds, and cofactors inaptamer evolution. In The Aptamer Handbook (Kluss-mann S, ed.), pp. 54–92....