Báo cáo khoa học: Abortive translation caused by peptidyl-tRNA drop-off at NGG codons in the early coding region of mRNA potx
Báo cáo khoa học: Abortive translation caused by peptidyl-tRNA drop-off at NGG codons in the early coding region of mRNA potx
... prone to a codondependent peptidyl-tRNA drop-off at the very begin-ning of the coding region in mRNA. In the case of NGG codons located close to the initiation codon suchinstability appears to ... associatedwith NGG in early coding reading in mRNA is the result of peptidyl-tRNA drop-off from the ribosomeduring translation in E. coli.ResultsInduction of a test gene with an early NGG codon ... inhibitgrowth of the strain even in the presence of IPTGinduction. All of these results suggest that the low geneexpression associated with NGG codons in the down-stream region following the initiation...
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Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt
... the apparentdissociation constant by Eqn (1). By assuming that the sample is saturated with Tb3+ at the starting point of the competition, the Ca2+-binding affinity is further obtainedusing ... facilitate oligomerization, it is challenging to differ-entiate which region contributes to the oligomerizationprocess.To overcome the limitations of investigating the Ca2+-binding sites in native ... lm). The binding of Ca2+resulted in a more compact conformation of the engineered protein. Our resultsalso showed that D to A mutations at Ca2+-coordinating loop positions 1and 3 of the...
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Báo cáo khoa học: Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages pdf
... alsoincreased (Fig. 1G,H). Taken together, these dataAcLDL12Visfatin/cyclophilin mRNAVisfatin/cyclophilin mRNA Visfatin/cyclophilin mRNA CD36/cyclophilin mRNA FABP4/cyclophilin mRNA Visfatin/cyclophilin ... dampened in the presence of visfatin small interferingRNA or by the visfatin-specific inhibitor FK866. Taken together, ourresults suggest that PPARc regulates the expression of visfatin in macro-phages, ... blocked[8], in line with the report that visfatin could bind andactivate insulin receptors [14]. However, the insulin-mimetic actions of visfatin are still debated [13]. Allthese data suggest that...
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Báo cáo khoa học: "CS NIPER Annotation-by-query for non-canonical constructions in large corpora" pdf
... 2008).A rule has the form category := pattern and createsnew annotation of the type category on any part of a text matching pattern. A rule for the annotation of passive clauses in the UAM CorpusTool ... annotation decisions thatexceed a certain inter-rater agreement threshold.This annotation -by- query approach of querying,assessing, evaluating and annotating allows multipledistributed raters ... present.These records contain the offsets of the sentence in the original text, the sentence text and the construc-tion type. In addition, an AnnotationCandidateLabelrecord is created for...
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Báo cáo khoa học: "Unsupervised Relation Extraction by Mining Wikipedia Texts Using Information from the Web" pdf
... precision usinglinguistic patterns, whereas surface patternsfrom Web frequency information contributegreatly to the coverage of relation extraction.• The combination of these patterns producesa ... clustering for relation cluster-ing. The dependency pattern has the properties of being more accurate, but the Web context has the advantage of containing much more redundant in- formation than ... generated sur-face pattern is a sequence of words. The distance of two surface patterns is defined as the fraction of the LD value to the length of the longer sequence.For estimating the number of...
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Báo cáo khoa học: Protein oligomerization induced by oleic acid at the solid–liquid interface – equine lysozyme cytotoxic complexes potx
... determined by following separately the strongsignals of the aromatic residues of equine lysozymeand the oleic acid protons at 1.15 p.p.m. The diffu-sion coefficients determined by following the ... and the aromatic residue resonances of equine lysozyme in the region of 6.5–7.5 p.p.m., as shown in Fig. 6B. Thisindicates intermolecular binding between lysozyme andoleic acid and that aromatic ... extensively, however, the nature of the conformational changes occurring in the proteins upontheir complex formation and the mechanisms of cyto-toxicity of the complexes are still debated [26,34].It...
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Tài liệu Báo cáo khoa học: Experimental proof for a signal peptidase I like activity in Mycoplasma pneumoniae, but absence of a gene encoding a conserved bacterial type I SPase pdf
... the amino terminus of the pro-tein. Using this method, we showed that asparagine 26represents the amino terminus of P40. Knowing, that the first amino acids of the processed P40 and P90 is the ... at its N-terminusinstead of a free amino group [32]. Therefore, the asparagine in position 26 was labeled within the intactprotein at its a-amino group and represents the aminoterminal amino ... 2,8 to the beads and incubating the suspensionfor 2 min at 20 °C. The beads were again removed by the magnet and the supernatant containing now the P40 wasneutralized by adding 1 mL of 0.1...
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Tài liệu Báo cáo khoa học: "STRING-TREE CORRESPONDENCE GRAMMAR: A DECLARATIVE GRAMMAR FORMALISM FOR DEFINING THE CORRESPONDENCE BETWEEN STRINGS OF TERMS AND TREE STRUCTURES" pdf
... string of terms and a structural representation is defined as a mapping between elements of the set of substrings of the string and elements of the set of subtrees of the tree : such a relation ... also note that the nodes in the TREE are simply concepts in the structural representation and thus the interpretation is independent of any grammar that defines the correspondence (in fact, we ... tanciations of the variables in STRUCTU- RE can be obtained only by identifying (an operation intuitively similar to the standard notion of unification - again, see later in fig. 5) the STRUCTURE...
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Báo cáo khoa học: Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain pdf
... cleavage of dinucleoside polyphosphate molecules modified in theirADP moieties. In addition, none of the oxymethyleneanalogs investigated inhibited the hydrolysis of Ap4Acatalyzed by the E. ... ab,a¢b¢-disubstituted analogs of Ap4A (e.g. ApCHFppCHFpA was cleaved at 3% of the rate of AppppA) [22]. They constitute a symmet-rical mode of cleavage of 5 by water attack at Pb. The failure of these hydrolases ... mode and in the case of the lupin enzyme itwas over 20 times slower. Such slower cleavage to give18 could arise either from weaker binding of 3 in the active site of the hydrolase in the reverse...
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Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the specificity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf
... of the side chain d-guanidinogroup of this residue are involved in H-bonding as follows: Ne with the O atom of the main chain CO group of the TrpB240;Ng1shares H bonding with O atom of the ... substrates docked in the active site of penicillin acylase by AM1 calculations. Amino acid residues of the enzyme are at their X-ray coordinates [19]. Substrates having local symmetry of the leaving ... that the ArgB263 residue could be involved both in catalysis andproductive binding.Graphic simulation of the interactions of arylamidesubstrates with the nucleophile binding subsite of PAindicates...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpBáo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ