Báo cáo khoa học: Inhibition of Hsp90 function delays and impairs recovery from heat shock ppt

... FEBS Inhibition of Hsp90 function delays and impairs recovery from heat shock Roger F Duncan 1,2 1 Department of Molecular Pharmacology and Toxicology, University of Southern California School of Pharmacy, ... heat- denatured proteins, or some other detrimental consequence of heat shock. Inhibition of Hsp90 function by ansamycins also sig- nificantly...

Ngày tải lên: 30/03/2014, 20:20

... reactions of trans-sulfura- tion through the production of homocysteine, biologi- cal methylations of DNA, lipids and proteins, and polyamine biosynthesis through the production of methionine and S-AdoMet ... pteridine substructure of 5-methyltetrahydrofolate, one of the two substrates of MetS 2 (Fig. 1), and carry functionalities that may facili- tate molecular recognit...

Ngày tải lên: 19/02/2014, 05:20

... comparing models of the aryl acid binding pockets of the two domains. Results and Discussion Inhibition of DhbE with SAL-AMS and a set of new modified inhibitors In order to study inhibition of a DHB ... 3D. Determination of inhibition constants for SAL-AMS and DHB-AMS with DhbE and YbtE The DHB-AMS and SAL-AMS were selected for detailed inhibition studies. Target...

Ngày tải lên: 23/03/2014, 11:20

... horikoshii and Sulfol- obus tokadaii, and characterized from a biochemical and structural point of view only from E. coli and S. tokadaii [8–17]. It is a flavoprotein containing 1 mol of noncovalently ... contained 70 lg of NadA, 30 lgof NadB and 1 mm fumarate under anaerobic conditions. AB Fig. 1. Production and purification of NadA from Bacillus subtilis. (A) 11% SDS...

Ngày tải lên: 30/03/2014, 02:20

... extraction from comparable corpora. It consists of tools bundled in two workflows: (1) alignment of comparable documents and extraction of parallel sentences and (2) extraction and bilingual ... mapping of terms and named entities. The toolkit pairs similar bilingual comparable documents and extracts parallel sentences and bilingual terminological and named enti...

Ngày tải lên: 16/03/2014, 20:20

... viability and liberation of viru- lence factors. Inhibition of autolysis by excess cho- line might, in the first instance, seem to be of therapeutic interest. However, the amount of ligand needed, and ... analysis of ligand binding to C-LytA. (A) Con- formational changes induced by ligands on C-LytA monitored by near-UV CD with no ligand added (—) and upon addition of ligan...

Ngày tải lên: 19/02/2014, 05:20

... for appropriate binding of the metal ion, which remains accessible from the exterior (Fig. 7B). Distances between the N5 and O4 of the flavin, O of Ser90, S of Cys266, O of Glu306 and O of Tyr308 indicate ... [51,52]. The O of Ser90 and the S of Cys266 of pea FNR are close to N5 and O4 of the isoalloxazine, which are involved in hydride transfer. The hydroxy group...

Ngày tải lên: 19/02/2014, 16:20

... inactivation of G APDH being metal- ion independent, whereas inhibition of GR and LDH by H 2 O 2 occurs most rapidly in the presence of metal ions. It is proposed that the inhibition of GAPDH and GR ... inactivation of GAPDH and GR occurs via oxidation of nonactive site residues, that bring about loss of functional integrity, the stoichiometry of inactivation ( i.e....

Ngày tải lên: 21/02/2014, 03:20

... lg), and exhibited downregulation of P-gp at both the mRNA and protein levels (Fig. 4A). Inhibition of the PI3K/Akt pathway decreased the expression of P-gp induced by PrP C at both the mRNA and ... and increasing release of these drugs (ADR and VCR) [5]. PrP C -mediated multidrug resistance (MDR) was thought to be related to upregulation of P-glycoprotein (P-gp) [6] an...

Ngày tải lên: 07/03/2014, 03:20

... the presence of IRE, we measured hydrolysis of [ 32 P]ATP[cP] in the presence of 0–400 ng of IRE (Fig. 8). Compared to the amount of ATP hydrolyzed with 400 ng of IRP alone, addition of IRE increased the ... ATP binding and hydrolysis Zvezdana Popovic and Douglas M. Templeton Laboratory Medicine and Pathobiology, University of Toronto, Canada Mechanisms of post-transcr...

Ngày tải lên: 07/03/2014, 09:20