Báo cáo khoa học: Inhibition of Hsp90 function delays and impairs recovery from heat shock ppt
Báo cáo khoa học: Inhibition of Hsp90 function delays and impairs recovery from heat shock ppt
... FEBS Inhibition of Hsp90 function delays and impairs recovery from heat shock Roger F Duncan1,21 Department of Molecular Pharmacology and Toxicology, University of Southern California School of Pharmacy, ... heat- denatured proteins, or some other detrimentalconsequence of heat shock. Inhibition of Hsp90 function by ansamycins also sig-nificantly delays the recovery of normal, nonheat shock ... induce a heat shock response in the absence of heat shock We hypothesize that Hsp90 function regulates facets of the heat shock response, as has been documented forHsp70 [3,6,8]. Ansamycin Hsp90...
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Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx
... reactions of trans-sulfura-tion through the production of homocysteine, biologi-cal methylations of DNA, lipids and proteins, and polyamine biosynthesis through the production of methionine and S-AdoMet ... pteridine substructure of 5-methyltetrahydrofolate, one of the two substrates of MetS2(Fig. 1), and carry functionalities that may facili-tate molecular recognition.The synthesis of compounds 1c–k ... result of this approach indicated the orienta-tion of 5-methyltetrahydrofolate in the MetS activesite. Figure 5 shows the superimposed structures of DHPS and 5-methyltetrahydrofolate. The model of...
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Báo cáo khoa học: Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis ppt
... comparing models of the aryl acid binding pockets of the two domains.Results and Discussion Inhibition of DhbE with SAL-AMS and a set of new modified inhibitorsIn order to study inhibition of a DHB ... 3D.Determination of inhibition constants forSAL-AMS and DHB-AMS with DhbE and YbtEThe DHB-AMS and SAL-AMS were selected fordetailed inhibition studies. Target enzymes wereTable 1. Results of inhibition ... estimation of the preferential inhibition of DhbE and the SAL A domain, YbtE, bytwo analogues corresponding to the native products of catalysis. The relationship between substrate specificity and inhibition...
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Báo cáo khoa học: Characterization of L-aspartate oxidase and quinolinate synthase from Bacillus subtilis potx
... horikoshii and Sulfol-obus tokadaii, and characterized from a biochemical and structural point of view only from E. coli and S. tokadaii [8–17]. It is a flavoprotein containing 1 mol of noncovalently ... contained 70 lg of NadA, 30 lgofNadB and 1 mm fumarate under anaerobic conditions.ABFig. 1. Production and purification of NadA from Bacillus subtilis.(A) 11% SDS ⁄ PAGE of NadA–His before and after ... University of Pavia, Italy2 D.I.P.A.V., Section of Biochemistry, University of Milano, Italy3 School of Biological and Chemical Sciences, Queen Mary College, University of London, UK4 Institute of...
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Báo cáo khoa học: "Toolkit for Multi-Level Alignment and Information Extraction from Comparable Corpora" pptx
... extraction from comparable corpora. It consists of tools bundled in two workflows: (1) alignment of comparable documents and extraction of parallel sentences and (2) extraction and bilingual ... mapping of terms and named entities. The toolkit pairs similar bilingual comparable documents and extracts parallel sentences and bilingual terminological and named entity dictionaries from ... {f.su,b.babych}@leeds.ac.uk Abstract The lack of parallel corpora and linguistic resources for many languages and domains is one of the major obstacles for the further advancement of automated translation. A...
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... viability and liberation of viru-lence factors. Inhibition of autolysis by excess cho-line might, in the first instance, seem to be of therapeutic interest. However, the amount of ligandneeded, and ... analysis of ligand binding to C-LytA. (A) Con-formational changes induced by ligands on C-LytA monitored bynear-UV CD with no ligand added (—) and upon addition of ligands:s, d, 2.5 and 20 mM ... con-centration of choline capable of eluting C-LytA from a DEAE-cellulose column, 1 mg of C-LytA sampleswere adsorbed onto 1 mL of resin and subjected towashes with different concentrations of choline....
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Tài liệu Báo cáo khoa học: Inhibition of pea ferredoxin–NADP(H) reductase by Zn-ferrocyanide docx
... forappropriate binding of the metal ion, which remainsaccessible from the exterior (Fig. 7B). Distances betweenthe N5 and O4 of the flavin, O of Ser90, S of Cys266, O of Glu306 and O of Tyr308 indicate ... [51,52].The O of Ser90 and the S of Cys266 of pea FNR are closeto N5 and O4 of the isoalloxazine, which are involved inhydride transfer. The hydroxy group of Ser90 could accept ahydrogen bond and thus ... ferricyanide (d), DCPIP(s) and f erredoxin (m) as electron acceptors.(C) Inhibition of ferricyanide (d )and DCPIP (s) diaphorase activities of E. coliFPR as a function of Zn -ferrocyanide con-centration....
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Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx
... inactivation of G APDH being metal-ion independent, whereas inhibition of GR and LDH byH2O2occurs most rapidly in the presence of metal ions.It is proposed that the inhibition of GAPDH and GR ... inactivation of GAPDH and GR occurs via oxidation of nonactive siteresidues, that bring about loss of functional integrity, thestoichiometry of inactivation ( i.e. the loss of two molecules of thiol ... lifetime of these protein peroxides may allow these species to diffuseconsiderable distances from their site of formation, and hence induce damage at remote sites. The concentrations of peptide and...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... lg), and exhibited downregulation of P-gp at boththe mRNA and protein levels (Fig. 4A). Inhibition of the PI3K/Akt pathway decreased the expression of P-gpinduced by PrPCat both the mRNA and ... and increasing release of these drugs (ADR and VCR) [5].PrPC-mediated multidrug resistance (MDR) wasthought to be related to upregulation of P-glycoprotein(P-gp) [6] and inhibition of apoptosis [6–9]; ... level of p-Akt was increased inPrPC-transfected cells. Inhibition of PrPCexpression by RNA interferenceresulted in decreased p-Akt expression. Inhibition of the PI3K/Akt path-way by one of...
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Báo cáo khoa học: Inhibition of an iron-responsive element/iron regulatory protein-1 complex by ATP binding and hydrolysis docx
... thepresence of IRE, we measured hydrolysis of [32P]ATP[cP] in the presence of 0–400 ng of IRE(Fig. 8). Compared to the amount of ATP hydrolyzedwith 400 ng of IRP alone, addition of IRE increasedthe ... ATP binding and hydrolysisZvezdana Popovic and Douglas M. TempletonLaboratory Medicine and Pathobiology, University of Toronto, CanadaMechanisms of post-transcriptional regulation of geneexpression ... than of direct chemical modification of the 4Fe)4S clusterby H2O2[9,16,17]. Indeed, superoxide, H2O2, and HOare all capable of damaging components of the elec-tron transport apparatus, and...
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