Báo cáo khoa học: Pleiotrophin inhibits HIV infection by binding the cell surface-expressed nucleolin docx

... nucleolin. Results Inhibition of HIV- infection by PTN We investigated the inhibitory effect of PTN on HIV infection by using the experimental model of HeLa P4 or HeLa P4C5 cells. HIV entry and replication in these cells ... 5. The effect of the nucleolin binding molecules on the binding of PTN to the low and high affinity -binding site. (A) Inhibitory effect...

Ngày tải lên: 30/03/2014, 20:20

... disambiguation. The semantic frame of the predicate verb and the argument structures in a sentence can be identified by the syntactic structure, part-of- speech tags, head word, and other features in the ... threshold. If the frames are small and therefore do not contain many lexical entries, then these frames might not be correctly mapped. If the parent concept classes ar...

Ngày tải lên: 17/03/2014, 04:20

... which is furthermore anchored to the cell by interactions with cell- surface receptors, in particular, the integrins and a-dystroglycan [28]. The BM and the ECM in general provide the milieu through ... by other members of the glypican family. The testicans are a subgroup of the BM-40 ⁄ SPARC ⁄ osteonectin family of modular proteins. There is no documented evidence of t...

Ngày tải lên: 30/03/2014, 02:20

... schema matches the categories of the top 2 cells of the Stack, then they are popped from the Stack and the new category formed by applying the rule schema is pushed onto the Stack. The Permutation ... entry in the top cell (in- troduced by Shift or Reduce) a WML value of 0 2. Increment every Stack cell& apos;s WML value by 1 3. Push the sum of the WML val...

Ngày tải lên: 31/03/2014, 21:20

... changes [1]. Because many ther- apeutic agents eliminate tumor cells by inducing apop- totic cell death, the further understanding of the apoptotic mechanisms is required for the prevention and treatment ... cells (%) Fig. 1. Oridonin-induced ROS generation was blocked by NAC in L929 cells. The cells were incubated with medium or 50 lM oridonin for 24 h. The cellular ultrastru...

Ngày tải lên: 18/02/2014, 13:20

... V30M TTR proteins. The extent of fibril formation can be calculated as the percentage of the turbidity (absorbance at 330 nm) of the oxidized proteins divided by the turbidity of the unoxidized proteins. ... 44% for the oxidized protein. These data show that the decrease in turbidity is not due to different properties of the fibril formed by oxidized relative to unoxidized...

Ngày tải lên: 19/02/2014, 05:20

... nanoparticles have been internalized in cells by this strategy. One of these translocating peptides was derived from the HIV- 1 Tat protein. The mechanisms by which CPP enter cells remain unknown. Recently, ... reduction of the intracellular signal (data not shown). Whether there is saturation of intracellular binding sites or competition at the level of membrane structu res im...

Ngày tải lên: 21/02/2014, 03:20

... were depolymerized by incubating the HeLa cells on ice for 1 h. Then, the kinetics of the reassembly of the microtubules in live HeLa cells was B A Fig. 3. Effects of rotenone on the microtubules ... dissociates from the kinetochore region and the cells progress towards anaphase [25]. In the control cells, BubR1 was not detected near the metaphase plate in the mitotic He...

Ngày tải lên: 07/03/2014, 05:20

... structures, the rest of bacitracin A as ‘Bacitracin A’, and all other amino acids not involved in the crosslink by the sin- gle-letter code. The PDI peptide side of the disulfide bond is named R1, and the ... making them the active antimicrobial compounds of the bacitracin mix. The oxidation of the amino-thiazoline ring to the keto-thiazole ring to form bacitracin H and...

Ngày tải lên: 14/03/2014, 23:20

... assays. CD, cell death. Table 1. Percentage of cells in each phase of the cell cycle as evaluated by flow cytometry. Percentage of cells in the phases of the cellcycle G 1 SG 2 ⁄ M Cell death C33A ... increase in the per- centage of cells with a smaller amount of DNA in the so-called sub-G 1 phase, thus indicating cell death. CASKI cells were the most responsive to the...

Ngày tải lên: 16/03/2014, 00:20