Báo cáo khoa học: The protein tyrosine phosphatase PTP-Basophil/Basophil-like Interacting proteins and molecular functions doc

... kinases and counteracted by the activity of protein tyrosine phosphatases [1]. The family of protein tyrosine phosphatases (PTPs) is divided into two major subtypes: (a) the receptor-like and (b) the ... domains. Many of these interacting proteins are implicated in the regulation of the actin cytoskeleton. However, some proteins demonstrate a nuclear function of...

Ngày tải lên: 30/03/2014, 20:20

... from the PAL- based models. Merging the MIO portions to the mono- mers and building the ‘Tyr-loop-out’ tetrameric models (PlPAL out and SmPAL out ) was achieved in the same way as described for the ... the biosynthesis of the photoactive yellow protein chromophore of these bacteria. The two recently discovered aminomutases, the phe- nylalanine 2,3-aminomutase (PAM) i...

Ngày tải lên: 07/03/2014, 12:20

... these lesions and the abundant undamaged DNA present in the genome (including the intact DNA strand opposite the lesion). Depending on the precise location of the damaged DNA, the NER pro- cess ... repair (NER). XP proteins A–G are crucial in the processes of DNA damage recognition and incision, and patients with XP can carry mutations in any of the genes that specif...

Ngày tải lên: 07/03/2014, 12:20

... with thiol groups, and the cadmium speciation of the wild-type and the CeMT-2 knockout strain was distinctly different to the CeMT-1 and double knock- outs. Taken together, and supported by a simple ... heterogeneous superfamily of proteins, and that they are ‘multipurpose’ proteins [13], with roles in protection against cadmium toxicity [14], essential Cu(I) and Zn(II)...

Ngày tải lên: 16/02/2014, 15:20

... sequence homology class V, thereby distinguishing them from the cytoplasmic class I acidic keratins, the class II basic keratins, the class III desmin-like proteins and the class IV neuronal IF proteins [10,11]. ... transmembrane proteins and chromatin associating factors. The constituent proteins, the lamins, have recently gained tremendous recognition, because mutatio...

Ngày tải lên: 19/02/2014, 02:20

... level, and then the ranking they obtain in the AE05 testbed. There are substantial swaps between both rankings. In- deed, the Pearson correlation of both ranks is only 0.26. This result supports the ... associate the i th translation according to the metric ranking with the quality value manually assigned to the i th translation in the manual ranking. Being Q h (t) and Q...

Ngày tải lên: 20/02/2014, 07:20

... mother, and Bill does too. The stranded auxiliary in the second clause (the target clause) indicates the deletion of a verb phrase, a representation for which is to be located from an- other ... happens when the main verb of the second clause is the stative verb be, as in Sue criticized Penny and she was gloomy. These sentences contain the resultmeaning of and...

Ngày tải lên: 20/02/2014, 21:20

... regions of the protein: at the interface between the two subunits (mainly in loop IV and b 8), in the odd loops and at the corresponding end of the b barrel, and in the even loops [52–56]. Some of the ... refined further through REM calculations. The rmsd to the mean structure of the family is 0.79 ± 0.11 and 1.35 ± 0.09 A ˚ for the backbone and the heavy a...

Ngày tải lên: 21/02/2014, 03:20

... with water from the faucet. Yet, not only is water never mentioned in the sentence, there is nothing there to explicitly relate turning on the faucet and filling the glass. The glass could ... eyes. These actions are enabled regardless of whether the window is open or closed. That Is, one can see through a window, and therefore read or observe things on the other si...

Ngày tải lên: 21/02/2014, 20:20

... deep within the protein, is formed by amino acids from each domain and includes the catalytic triad and both conserved and variable residues. These proteins are hollow and accommodate the substrate, which ... some differences in their cellular effects. Therefore, these two proteins are likely to have different functions and ligands. The mechanism of action of intracel...

Ngày tải lên: 06/03/2014, 09:22