Báo cáo khoa học: Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (AriceptÒ) to cholinesterases doc

... binding of E2020 to BChE is due to the absence of aromatic residues at positions 68, 119, and 277, then replacement of these residues by aromatic residues should improve the binding of E2020 to mutant ... between the indanone ring of E2020 and Trp279 of AChE at the peripheral anionic- site and between the benzyl ring of E2020 a...

Ngày tải lên: 30/03/2014, 20:20

... connect the Uterals The final step in assembling the proof net is to con- nect together the literal nodes at the top of the graph. It is at this stage that unification is applied to the variables ... fragment of linear logic, which uses only the multiplicative conjunction operator ® (tensor) and the linear implication operator o. The same fragment is obt...

Ngày tải lên: 22/02/2014, 03:20

... per- formed at temperatures of 48–60 °C. The optimal rate of precipitation of yeast ADH for monitoring precipi- tation was found to be 55 °C (not shown), and the inactivation and precipitation of yeast ... pre- cipitate sinking to the bottom of the cuvette and there- fore not obscuring the light path [42]. Thus, the Q194A mutant showed thermostability similar...

Ngày tải lên: 07/03/2014, 04:20

... Summary of alanine scanning of the 4-kDa peptide. The results are expressed as the ratio of dissociation of the variant to that of the wild-type. The amino acids mutated to alanine are designated ... 1. Gel-filtration chromatography of the 43-kDa protein and the 4-kDa peptide/43-kDa protein complex. (A) Chromatogram of the 43-kDa protein. (B) Chromatogram...

Ngày tải lên: 17/03/2014, 03:20

... that were stable on the CLEF collection (Peters, 2003): 5 and 20 as the maximum numbers of documents and words, respectively. The relative weight of the expanded portion with respect to the ... Once the similarity is computed for each document in the parallel corpora, only the top N most similar documents are kept for training. They are an approximation of...

Ngày tải lên: 17/03/2014, 06:20

... parentheses, at either the beginning or end of the line. It might be possible to standardize on the beginning of the line, and to use the open-parenthesis sign, (, at the left to indicate ... differences between the work at The University of Michigan and other work in machine translation is in the emphasis placed on the problem of multiple meani...

Ngày tải lên: 23/03/2014, 13:20

... the 515-nm band is absent, indicating the loss of ligand binding (Fig. 2A). Therefore, the intensity change of the 515-nm band was used to follow denaturation. The TetR[atc–Mg] 2 complexexcitedat455nmshowsalsoanemissionmaxi- mum ... change of the energy transfer signal at the wavelength with the maximal difference of fluorescence between the native and the de...

Ngày tải lên: 30/03/2014, 13:20

... occur in the machine memory, and for the automatic recognition and transfer to the output of words which, both graphically and in meaning, are shared by the two languages con- cerned in the machine ... Seattle MACHINE TRANSLATION development at the University of Washington is a joint enterprise of the Department of Far Eastern & Slavic Lan- guages &a...

Ngày tải lên: 30/03/2014, 17:20

... that the machine would make in order to initiate the word order changes. Examples of the sort of choices of meaning that could be made on the basis of sentence structure are not at all hard to ... by the U.S. Army (Signal Corps), the U.S. Air Force (Office of Scientific Research, Air Research and Deve- lopment Command), and the U.S. Navy (Office of Na...

Ngày tải lên: 30/03/2014, 17:20

... hypothesis that the effect of the Trp316Ser polymorphism was due to its non-random association with the )1CfiA mutation and that the effect of the Cys306Gly is independent, which is perhaps mediated by ... 0.0001). Of the 21 individuals with the Trp316Ser mutation, 20 had the )1CfiA mutation. On the other hand, of the 16 individuals with the Cys306Gly mutation,...

Ngày tải lên: 31/03/2014, 07:20