Báo cáo khoa học: Histone H2A phosphorylation in DNA double-strand break repair pot

... to DNA breaks. At least for Ino80, this may involve the Nhp10 protein, identified as important for Ino80-binding chromatin near DNA breaks [30]. As the Ino80 complex from an nhp10 mutant strain ... of the H2A or H2AX tail that were either unmodified or contained a phosphoserine residue in the SQ motif. Proteins containing known phosphoserine ⁄ threonine binding motifs such as BRCT or FH...

Ngày tải lên: 30/03/2014, 20:20

... proteins mutated at specific phos- phorylation targets. Recombinant murine p53 proteins were expressed in insect cells (using the baculoviral expression vector system) and in a mam- malian in vitro ... sig- nal of p53 and its phosphorylation involves S and G 2 ⁄ M cyclin-dependent kinases [21]. Our results now indicate that in protein derived from BVEs, an intact serine resi- due at...

Ngày tải lên: 30/03/2014, 16:20

... resolution. In structured data (e.g., databases), approaches have included minimizing the number of “matching” and “merging” operations (Benjel- loun et al., 2006), using global relational informa- tion(Malin, ... impor- tant in resolving personal names (Reuther, 2006), and take into account global relational informa- tion. Similarly, approaches in unstructured data (e.g., text) have in...

Ngày tải lên: 08/03/2014, 01:20

... set with increasing amounts of training data. In all cases for the table, we are evaluating on the same thirty document test set which is included in our training set, since our system in unsupervised. ... assignment” in that reference). 4 Inference Details Up until now, we’ve discussed Gibbs sampling, but we are not interested in sampling from the poste- rior P (Z|X), but in findi...

Ngày tải lên: 08/03/2014, 02:21

... building on this work, there are two differ- ent directions in which we can go. While this work uncovers some interesting results in the tutor- ing domain, there are some shortcomings in the ... proposed a finite-state turn-taking 94 model, which is used to predict end-of-turn and performed significantly better than a fixed- threshold baseline in reducing endpointing latency in a...

Ngày tải lên: 30/03/2014, 21:20

... tagging method d Using trivial internal dependencies in Scheme E. e Using annotated internal character dependencies. 5 Is Word Still Necessary? Note that this work is not about joint learning of ... word does not appear in a natural way as most European languages 2 , it 1 Character here stands for various tokens occurring in a naturally written Chinese text, including Chinese charac- te...

Ngày tải lên: 31/03/2014, 20:20

... proteinase K. DPP IV levels following stimulation with insulin and bpV(phen) In order to examine changes in DPP IV levels follow- ing insulin stimulation, rats were injected with the PTP inhibitor ... bisperoxovanadium 1,10-phenanthroline [bpV(phen)] was added to the incubation medium, DPP IV phosphorylation was enhanced at 0 (control) and 2 min, but not at 15 min postinsulin injection...

Ngày tải lên: 19/02/2014, 07:20

... followed their own definitions of different scoring values, such as excluding certain scores (see examples in table 1). They find the def- initions incorrect. If the veterinarian strictly follows ... the recording of metritis scores and veterinarians' decision making connected to metritis treat- ment and potential links to data quality. This understand- ing provides insight into potent...

Ngày tải lên: 25/10/2012, 10:45

... GS staining (B3), and 4¢,6-diamidino-2-phenylindole (DAPI) staining (B4), respectively. (B5-8) High magnification images of the boxed area in (B4) showing RPE65c staining (B5), GS staining (B6), ... enzymes and retinoid-binding pro- teins between photoreceptors and retinal pigment epi- thelium (RPE); it is essential for maintaining normal vision [3,4]. The key step in the retinoid visual c...

Ngày tải lên: 14/02/2014, 14:20

... protein kinase; MCF, macrophare chemotactic factor; MCIP, modulatory calcineurin-interact- ing protein; MDCK, Madin Darby canine kidney; MEF, mouse embryonic fibroblast; MEK, MAP kinase/ERK kinase; ... glycogen synthase) is insufficient to accurately explain insulin-stimulated changes in the concentration of intracellular species and partitioning of glucose disposal in skeletal muscle. Insu...

Ngày tải lên: 14/02/2014, 14:20