Báo cáo khoa học: Role of Tyr84 in controlling the reactivity of Cys34 of human albumin potx

... this binding. Some of these Fig. 10. Prediction of nucleolin-binding sites in human lactoferrin (hLf). Sequences of the N2 and C2 domains of hLf, bovine lactoferrin (bLf) and human transferrin (hTf) ... on the binding of HB-19. Similarly, the iron-binding hTf had no effect. On the other hand, bLf inhibited the binding of HB-19 to cells. In accordance with the i...

Ngày tải lên: 07/03/2014, 15:20

... Structural features of the Cys34 site in human serum albumin. (A) Domain structure of human serum albumin and location of Cys34. The coordinates used are those of pdb 1AO6 (albumin isolated from ... dramatic increase in reactivity for the Tyr84Phe mutant. We also report 1 H NMR studies of disulfide interchange reac- tions with cysteine. The tethering of th...

Ngày tải lên: 30/03/2014, 15:20

... is also the reason why the determination of the spatial structure of the N-terminal domain con- taining the Cd(II) 3 -CysS 9 cluster was thus precluded. For a more detailed discussion of the dynamics ... The cluster structure raises the possibility of a cooperative binding of the metal ions. Cooperative binding has been reported but is not always found, being depen...

Ngày tải lên: 16/02/2014, 15:20

... within the same cell. Furthermore, in cells expressing either the double or single mutants, we tended to see a decrease in the number of cells with the ability to reduce transferrin binding compared ... with binding immunoglobulin protein. J Biol Chem 266, 17648–17654. 42 Williams A & Enns C (1993) A region of the C-terminal portion of the human transferrin recepto...

Ngày tải lên: 06/03/2014, 22:21

... glass of beer. In (9), the development of the drinking event can be measured along the subparts of the glass of beer. Each subpart of the incremental theme argument is mapped onto a subpart of ... associate with the CONST qualia role of chambre such a collection of instances of the movable_phys__obj type, the CONST role describing the meronymic...

Ngày tải lên: 08/03/2014, 06:20

... the specific activity of wild- type and Ser102 CHIT1 in media of COS-transfected cells using silver-staining after gel electrophoresis. In their case, the protein signal staining intensities of aliquots ... located close to the binding cleft, we investigated whether possible hydrogen-bonding interactions of the serine hydroxyl might result in altered substrate binding. Be...

Ngày tải lên: 23/03/2014, 04:20

... L to participate in the production of kinins, using kininogens and synthetic peptides that mimic the insertion sites of bradykinin on human kininogens. Although both cathepsins processed high-molecular ... that cathepsin K is a new member of the kininase family. Both the kininogenase activity of cathepsin L and/or the kininase activity of cathepsin K may be favored by...

Ngày tải lên: 31/03/2014, 07:20

... enabling the user to extend the available working vocabulary without bilingual knowledge. The dictionaries, the user, and the system The dictionary creation routines, whether in monolingual ... implementation of independently motivated linguistic-theoretic descriptions. The informing principles are those of modern 'lexicalist' unification-based linguisti...

Ngày tải lên: 01/04/2014, 00:20

... mediator of lethal sepsis, triggering the production of proinflammatory cytokines and liver injury [13]. Therefore, the present study aimed to elucidate the role of KCs in the regulation of CYP isoform ... USA). Binding of all of the anti- bodies was detected using an ECL detection system (iNtRON Biotechnology, Seoul, Korea) in accordance with the manu- facturer’s...

Ngày tải lên: 14/02/2014, 18:20

... membrane proteins to migrate apically. Transcytosis of integrins would therefore enable H. pylori with the intriguing possibility of targeting the integrin b 1 receptor at api- cal membranes (Fig. 1). The ... signalling to activate the kinases FAK and Src [11], although mutation of the RGD-motif in CagL had no defect in T4SS functions such as phosphorylation of injected...

Ngày tải lên: 14/02/2014, 19:20