Báo cáo khoa học: Data-driven docking for the study of biomolecular complexes pptx

... finds the distinction between ‘bound’ and ‘unbound’ docking: the former refers to docking using the structures of the single pro- teins as they are present in the complex, and the latter to docking ... assessment of which residues of the labeled molecule are perturbed by the formation of the complex. One then repeats this procedure with the second molecule labe...

Ngày tải lên: 30/03/2014, 15:20

... for the optimal activity of BsArb43B. Furthermore, to determine whether the role of the calcium is structural, thermal shift assays were per- formed to determine the T m of the protein in the ... In the absence of the histidine residue, recognition and stabilization of the substrate are not as efficient as for the native enzyme, and the efficiency of the...

Ngày tải lên: 15/03/2014, 23:20

... lation of an external form of the chart, and modification of the internal form through inte- raction with the user, with the possibility of returning a new external form. - Interpretation of these ... for all the associated information. VISULEX offers two levels of detail. At the first level, the information is presented by using only the comments associ...

Ngày tải lên: 17/03/2014, 19:21

... orientation of the side chain of Glu221. The second conformation of the side chain of Glu221, which also adopts two conformations but not correlated with the anomeric form of the bound mannose is shown ... gly- cans complexes [34]. Therefore, we conclude that the reason for the difference in energetics of the )1 subsite between PAL and con A must be due to deta...

Ngày tải lên: 23/03/2014, 11:20

... germ lines. For clone 3F, VH3-VK3 were the closest families for V H and V L domains, respectively. In the case of C1, VH3- Vk1 were the families with highest scores. The specifici- ty of these two ... scorpion venom. The scFv 3F was matured in vitro by three cycles of directed evolution. The use of stringent conditions in the third cycle allowed the selection of s...

Ngày tải lên: 23/03/2014, 13:20

... analysis of one FS with the synthesis of another; they may be thought of as a specialized variety of pattern- matching rule. They are local in nature, and permit the recursive analysis and synthesis ... trate the use of the formalism in the areas of machine translation and reduction of FSs to canonical form. We conclude with an over- view of continuing strand...

Ngày tải lên: 01/04/2014, 00:20

... the native state, and D is the denatured state. On the other hand, analysis of the scan rate effect on the transitions of TetR in the presence of tetracycline shows that thermal unfolding of the ... in the spherical shape of the protein in the absence and presence of the ligand. The increasing linear dependence of R H on the concentration of wild-type...

Ngày tải lên: 20/02/2014, 02:21

... position of making decisions that directly result in the death of a loved one. Once life- supporting care is instituted, the patient has options for ‘survival’ that they did not have before, even ... though they are dependent on ‘life support’. There are now variables Commentary Medical treatment for the terminally ill: the ‘risk of unacceptable badness’ David Crippen Associ...

Ngày tải lên: 25/10/2012, 10:45

... occurrence of two phrase pairs in a Turkish-English parallel corpus and the two hypothesized sets of segmentations for the Turkish phrases as in Table 1. Without ac- cess to the English side of the ... to the next. The incremental updates are derived from the equations for the count collection and probability estimation steps of the EM algorithm as follows. In t...

Ngày tải lên: 20/02/2014, 04:20

... leading cells to death. The current model proposed for the mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing action of the cytosolic RNase inhibitor, ... indicate that the cell sulfhydryls responsible for the exchange with the protein disulfides are located in the plasma membrane. Furthermore, they show...

Ngày tải lên: 20/02/2014, 11:20