Báo cáo khoa học: Weapons of STAT destruction Interferon evasion by paramyxovirus V proteins ppt
Báo cáo khoa học: Weapons of STAT destruction Interferon evasion by paramyxovirus V proteins ppt
... MINIREVIEW
Weapons of STAT destruction
Interferon evasion by paramyxovirus V proteins
Curt M. Horvath
Department of Medicine, Evanston Northwestern Healthcare Research Institute, and Departments of ... to
STAT- directed therapeutics for diseases characterized by
STAT hyperactivity.
Keywords: antiviral; interferon; paramyxovirus; STAT; viral
evasion.
Interfero...
Báo cáo khoa học: Regulation of STAT signalling by proteolytic processing Lisa Hendry and Susan John doc
... critical roles played
by STAT proteins in regulating cell proliferation, differ-
entiation and survival. Consequently, the activity of STAT
proteins is negatively regulated by a variety of different
mechanisms, ... cells
Unlike Stat3 and Stat5 , which are activated by a wide
variety of cytokines and growth factors, Stat6 is very
selectively activated by IL-4 and the rel...
Tài liệu Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels pptx
... activity mediated by a relief of
inhibition by cyclophilin D was evident in the form of slightly increased
respiration rates during arsenolysis. However, the modulation of F
0
F
1
-ATP
synthase by ... liver
of a CYPD-WT mouse and, in lane 2, mitochondria
from the liver of a CYPD-KO mouse were loaded
(0.85 lg each), serving as a positive and negative con-
trol for the CYPD blot...
Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
... levels of
KLF4 were determined by real-time PCR. (B) Protein levels of KLF4
were determined by western blot. (C) mRNA levels of hSR-BI were
determined by real-time PCR. (D) Protein levels of ... enhance-
ment of the expression of the tumour suppressor gene
p53 [5]. Because of the important roles of KLF4 on
the above three cell types, we postulated the novel
effect of K...
Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx
... 5-methyltetrahydrofolate have
been evaluated in a cell-free system. The inhibitory
activity and mechanism of action have been probed by
kinetic studies using purified rat liver enzyme, whilst a
structure–activity ... vitro inactivation of mammalian
methionine synthase by nitric oxide. Eur J Clin Invest
26, 167–170.
15 Alston TA (1991) Inhibition of vitamin B12-dependent
methionine bi...
Tài liệu Báo cáo khóa học: Inactivation of copper-containing amine oxidases by turnover products doc
... different mechanisms
of substrate-induced inactivation have been proposed. One
consists of a slow oxidation by H
2
O
2
of a conserved residue
in the reduced enzyme after the fast turnover phase [Pietr-
angeli, ... both at
25 °Cand37°C, in a cuvette provided with a Teflon
stopper, thus limiting the amount of available oxygen and
allowing the monitoring of the UV-vis spectrum of rea...
Tài liệu Báo cáo khoa học: Regulation of the actin–myosin interaction by titin doc
... velocity v alues of moving filaments, both in
the a bsence and in t he presence of Tm–Tn–Ca
2+
,argues
against a simple effect of T800 on the calcium sensitivity
(pCa curve) of the movement and ... affected by ATP and/or
by CaCl
2
but it was decreased by elevating ionic strength
from 80 to 180 m
M
with average values of 62.3 ± 2.2%
and 45.1 ± 3.5%, respectively (compare d eta...
Tài liệu Báo cáo khoa học: "Types of Common-Sense Knowledge Needed for Recognizing Textual Entailment" ppt
... revise our
set of categories. Further surveys would be required
to validate this idea.
The 20 categories of knowledge covered 215
(97%) of the 221 statements of world knowledge
in our proofs. Of ... sig-
nificantly improved the overall κ score, several com-
binations provided minor improvements. As an ex-
ample of a merge that failed, we tried merging Ar-
gument Types and Mutual Ex...
Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx
... inactivation of
GAPDH and GR occurs via oxidation of nonactive site
residues, that bring about loss of functional integrity, the
stoichiometry of inactivation ( i.e. the loss of two molecules
of ... (molecular o xyge n in its
1
D
g
state;
1
O
2
)is
generated by a number of enzymatic and chemical reactions,
by UV exposure, and by visible light in the presence of a
number...
Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... in cleavage of a set of proteins,
resulting in disassembly of the cells. Caspase-3 is a major
effector caspase, and induces cleavage of several substrate
proteins and is responsible for several ... rate and differentiation
of F9 cells were not affected by the over-expression of
Hsp105a, the sensitivity of cells to oxidative stress was
enhanced by the over-expression of...
Từ khóa: