Báo cáo khoa học: Weapons of STAT destruction Interferon evasion by paramyxovirus V proteins ppt

... MINIREVIEW Weapons of STAT destruction Interferon evasion by paramyxovirus V proteins Curt M. Horvath Department of Medicine, Evanston Northwestern Healthcare Research Institute, and Departments of ... to STAT- directed therapeutics for diseases characterized by STAT hyperactivity. Keywords: antiviral; interferon; paramyxovirus; STAT; viral evasion. Interfero...

Ngày tải lên: 30/03/2014, 15:20

... critical roles played by STAT proteins in regulating cell proliferation, differ- entiation and survival. Consequently, the activity of STAT proteins is negatively regulated by a variety of different mechanisms, ... cells Unlike Stat3 and Stat5 , which are activated by a wide variety of cytokines and growth factors, Stat6 is very selectively activated by IL-4 and the rel...

Ngày tải lên: 30/03/2014, 15:20

... activity mediated by a relief of inhibition by cyclophilin D was evident in the form of slightly increased respiration rates during arsenolysis. However, the modulation of F 0 F 1 -ATP synthase by ... liver of a CYPD-WT mouse and, in lane 2, mitochondria from the liver of a CYPD-KO mouse were loaded (0.85 lg each), serving as a positive and negative con- trol for the CYPD blot...

Ngày tải lên: 14/02/2014, 19:20

... levels of KLF4 were determined by real-time PCR. (B) Protein levels of KLF4 were determined by western blot. (C) mRNA levels of hSR-BI were determined by real-time PCR. (D) Protein levels of ... enhance- ment of the expression of the tumour suppressor gene p53 [5]. Because of the important roles of KLF4 on the above three cell types, we postulated the novel effect of K...

Ngày tải lên: 18/02/2014, 04:20

... 5-methyltetrahydrofolate have been evaluated in a cell-free system. The inhibitory activity and mechanism of action have been probed by kinetic studies using purified rat liver enzyme, whilst a structure–activity ... vitro inactivation of mammalian methionine synthase by nitric oxide. Eur J Clin Invest 26, 167–170. 15 Alston TA (1991) Inhibition of vitamin B12-dependent methionine bi...

Ngày tải lên: 19/02/2014, 05:20

... different mechanisms of substrate-induced inactivation have been proposed. One consists of a slow oxidation by H 2 O 2 of a conserved residue in the reduced enzyme after the fast turnover phase [Pietr- angeli, ... both at 25 °Cand37°C, in a cuvette provided with a Teflon stopper, thus limiting the amount of available oxygen and allowing the monitoring of the UV-vis spectrum of rea...

Ngày tải lên: 19/02/2014, 12:20

... velocity v alues of moving filaments, both in the a bsence and in t he presence of Tm–Tn–Ca 2+ ,argues against a simple effect of T800 on the calcium sensitivity (pCa curve) of the movement and ... affected by ATP and/or by CaCl 2 but it was decreased by elevating ionic strength from 80 to 180 m M with average values of 62.3 ± 2.2% and 45.1 ± 3.5%, respectively (compare d eta...

Ngày tải lên: 19/02/2014, 16:20

... revise our set of categories. Further surveys would be required to validate this idea. The 20 categories of knowledge covered 215 (97%) of the 221 statements of world knowledge in our proofs. Of ... sig- nificantly improved the overall κ score, several com- binations provided minor improvements. As an ex- ample of a merge that failed, we tried merging Ar- gument Types and Mutual Ex...

Ngày tải lên: 20/02/2014, 05:20

... inactivation of GAPDH and GR occurs via oxidation of nonactive site residues, that bring about loss of functional integrity, the stoichiometry of inactivation ( i.e. the loss of two molecules of ... (molecular o xyge n in its 1 D g state; 1 O 2 )is generated by a number of enzymatic and chemical reactions, by UV exposure, and by visible light in the presence of a number...

Ngày tải lên: 21/02/2014, 03:20

... in cleavage of a set of proteins, resulting in disassembly of the cells. Caspase-3 is a major effector caspase, and induces cleavage of several substrate proteins and is responsible for several ... rate and differentiation of F9 cells were not affected by the over-expression of Hsp105a, the sensitivity of cells to oxidative stress was enhanced by the over-expression of...

Ngày tải lên: 21/02/2014, 03:20