Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment potx
Tài liệu Báo cáo khoa học: FOXM1c transactivates the human c-mycpromoter directly via the two TATA boxes P1 and P2 docx
... number of colonies number of colonies in % + Engr-ER-myc 0,9 310 7 Engr-ER-myc - 1, 09 91 FOXM1c (18 9-566)-Engr - 2,8635,5 FOXM1c (18 9-587; 744-762) - 1, 0694 FOXM1c (18 9-762) - 1, 0694 - 11 00control + 11 00control Gal-Engr - 1, 1686 FOXM1c (18 9-743)-Engr - 2,9234,8 76 218 9 76 218 9 744587 18 9 743 Engr-RPD GAL Engr-RPD Engr-RPD ER-HBD 566 18 9 Engr-RPD Fig. ... pmyc(-224...
Ngày tải lên: 19/02/2014, 05:20
Báo cáo khóa học: Acharan sulfate, the new glycosaminoglycan fromAchatina fulica Bowdich 1822 Structural heterogeneity, metabolic labeling and localization in the body, mucus and the organic shell matrix docx
... forms of acharan sulfate are present in the soft body, mucus and the organic shell matrix The GAG component of the soft body, mucus and the organic shell matrix of the giant African snail was isolated Ó ... Proteus vulgaris. (Received 17 November 2003, accepted 12 January 2004) Eur. J. Biochem. 2 71, 845–854 (2004) Ó FEBS 2004 doi :10 .11 11/ j .14 32 -10 33.2004.03989...
Ngày tải lên: 16/03/2014, 16:20
Tài liệu Báo cáo khoa học: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor pdf
... . . . SP K1 K2 TM 0 10 20 30 40 50 60 70 80 90 10 0 0. 01 0 .1 1 10 10 0 10 00 Fig. 2. Dose dependence of the inhibitory activity of soluble forms of HAI -1 and HAI-2 against the protease activity of TMPRSS13. ... Schematic representation of the structure of the full-length HAI -1 (1) and soluble forms of HAI -1, HAI -1 NK1LK2 (2) and HAI -1 NK1 (3), tag...
Ngày tải lên: 15/02/2014, 01:20
Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment potx
... Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment Trine N. Rasmussen 1, 3 , Ivana Novak 3 and Søren M. Nielsen 2 1 Department ... neuro- peptide first isolated in 19 81 [1] as the main stimulator of the release of adenocorticotropin from the pituitary. By activa- tio...
Ngày tải lên: 30/03/2014, 15:20
Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... revised 5 May 2006, accepted 15 May 2006) doi :10 .11 11/ j .17 42-4658.2006.05 319 .x Heme oxygenase consists of two structurally related isozymes, heme oxyge- nase -1 and and heme oxygenase-2, each of ... analysis. Opposite effects of hypoxia on expression of HO -1 and HO-2 mRNA in YN -1 cells To explore the mechanism of the hypoxia-mediated reduction of HO -1 and...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... k cat (s -1 ) K m Arg (mM) k cat ⁄ K m Arg (M -1 Æs -1 ) Wild-type 249 ± 10 1. 4 ± 0 .1 177.9 His120Asn 13 1 ± 8 1. 6 ± 0 .1 81. 9 His145Asn 238 ± 12 1. 5 ± 0 .1 158.6 Asn149Asp ND ND ND Fig. 1. Fluorescence ... consequence of the mutagenic replacements. Effects of the His120Asn and His145Asn mutations on the affinity of metal binding to arginase II To further exa...
Ngày tải lên: 20/02/2014, 02:21
Báo cáo khoa học: Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the 1 level of phosphorylation of IRS1 in type 2 diabetes pot
... 1. 1 1. 8 1. 1 1. 8 1. 1 1. 8 IRS1 0.6–0.7 0.6–0.7 1. 8–2.0 1. 8–2.0 1. 8–2.0 1. 8–2.0 PKB 0.9 1. 1 0.3–0.4 0.6–0.7 0.6–0.7 0.6–0.7 0.6–0.7 Glucose transport 0 .1 0.2 0.02–0.03 0 .1 0.2 0 .1 0.2 0 .1 0.2 0 .1 0.2 A. ... the dose–response curves in Figs 2,4, and 7. Analysis Subjects Normal Female diabetic Male diabetic Directly o ⁄ n Directly o ⁄ n Directly o ⁄ n Insulin receptor...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Internalization of cystatin C in human cell lines docx
... flow cytometry and the median of the fluorescence of the cell population was calculated, corrected for the control value and then related to the degree of labelling of the protein used. Dashes and rings ... & Lee AG (19 79) Thermostable endogenous inhibitors of cathepsins B and H. Eur J Biochem 10 1, 15 3 16 1. Supporting information The following supplemen...
Ngày tải lên: 16/03/2014, 06:20
Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx
... intermediate for the coupled hydroxylation of the cosubstrates [ 21, 41] . However, the sequence of binding of cofactor and substrate is still a matter of discussion and may be different comparing wild-type and ... ana- lysis [11 ] and modulation of Ser16 phosphorylation by PKA [12 ]. The binding studies by Shiman and collaborators [11 ,15 ] were interpreted t...
Ngày tải lên: 17/03/2014, 09:20
Báo cáo khoa học: Expressed as the sole Hsp90 of yeast, the a and b isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90b generates sensitivity to the Hsp90 inhibitor radicicol pdf
... in response to Mkk1 ⁄ 2-directed phosphorylation of the MAP kinase activation loop [3 ,14 ,18 ], Y2H interaction of these MAP kinases with the two isoforms of human Hsp90 was strengthened by heat shock ... sensitivity is normally associated with compromised activity of the Hsf1p CT domain [14 ,22], the compromised heat activation of this domain with Hsp90b present in...
Ngày tải lên: 23/03/2014, 07:20