Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated doc
Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated doc
... results. Interestingly, these truncated proteins are
O-GlcNAc modified in their C-terminal tail (residues
670–7 11) and not in the DNA-binding domain, as for t he
full-length proteins. Thus, the O-GlcNAc ... 670–7 11)
and not in the DNA-binding domain (Fig. 6). These results
provide another convincing example highlighting the
AB
Fig. 7. The glycosylated t runcated forms...
Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
... DP9-overexpressing cells of the
ECM-interacting molecules discoidin domain receptor
1, a kinase activated by collagen binding, and the
MMP inhibitor, tissue inhibitor of matrix metallopro-
teinase-2, ... for
different cancers. Further understanding of the biologi-
cal anti-invasive effect of DPIV in vitro could be of
importance in the control of certain carcinomas.
FAP distributio...
Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
... [45,46].
SDS–PAGE analysis of the purified proteins indicated that
they contained < 5% contaminating proteins. The concen-
trations of proteins used in these studies were determined
by spectrophotometric ... stacking
interactions of arginine and aromatic side-chains in
proteins. J Mol Biol 235, 709–717.
43 Lindner RA, Treweek TM & Carver JA (20 01) The
molecular chaperone a-c...
Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... keep the mass cen-
tre of the protein (marked with a black dot in Fig. 4) onto
the axis z, and (b) to conserve the minimal distance
between protein and membrane at 3.5 A
˚
.
The EIE, i.e., the ... proteins, with high
isoelectric point values. Thus we investigated the effects
Table 1. Natural and engineered RNases investigated in this study. IC
50
is the RNase concentrati...
Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... N-linked oligosaccharide side-chains
are important for the GABA transport activity.
1-Deoxymannojirimycin inhibits the GABA-uptake
of GAT1
In order to gain further insight into the role of the
terminal ... for the stability of this protein,
but the terminal structure of the N-glycans is not.
Defective N-glycosylation reduces the trafficking
of GAT1 to the plasma membrane...
Tài liệu Báo cáo khoa học: "The Sentimental Factor: Improving Review Classification via Human-Provided Information" docx
... produc-
ing information about the opinions that a document
contains; for instance, Morinaga et al. (2002). In
March, 2004, the American Association for Artifi-
cial Intelligence held a symposium in this ... class: linear estimates for the logit.
This understanding facilitates further extensions, in
particular, utilizing the following:
1. Labeled documents
2. More anchor words
Th...
Tài liệu Báo cáo khoa học: The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase doc
... accomplish the selective
charge–charge interaction. The presence of an additional
histidine residue in the prolyl 4-hydroxylase binding site
may be required to maintain the lysine side-chain in a
positively ... 2-OG. The
difference in the levels of coupling between 2-OG and
penicillin G or ampicillin oxidation is probably a reflected in
the apparent K
m
values for these...
Tài liệu Báo cáo khoa học: "THE REPRESENTATION OF INCONSISTENT INFORMATION IN A DYNAMIC MODEL-THEORETIC SEMANTICS" ppt
... in the table
using the ~-expression, and then finding the
corresponding element in the model. If the element
in the model that was the denotation of the
h-expression was not expanded in the ...
Mechanisms are introduced to eliminate these local
(temporary) inconsistencies, but the most natural
mechanism can introduce
permanent
inconsistencies
in the inf...
Tài liệu Báo cáo khoa học: "THE INTERPRETATIONOF TENSE AND ASPECT IN ENGLISH" potx
... necessary;
in this case, it is precisely the end point of the
building event that coincides with the beginning
of the event of the house being new. In a system
using Allen's primitives, the ...
tion that the cake is warm while John is frosting
it, the time span during which the cake is warm
must include the time 3:00; however, the starting
and end...
Tài liệu Báo cáo khoa học: "The Use of Shared Forests in Tree Adjoining Grammar Parsing" pptx
... BLSa' ] is the distinguished child of
ALSa ]. Given a derivation, the distinguished de-
scendant relation is the reflexive, transitive closure
of the distinguished child relation.
The language ... node. In 7 t the nodes contributed
by/3 have the same constraints as those associated
with the corresponding nodes in/ 3. The remaining
nodes in 7 ~ have the...
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