Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated doc

... results. Interestingly, these truncated proteins are O-GlcNAc modified in their C-terminal tail (residues 670–7 11) and not in the DNA-binding domain, as for t he full-length proteins. Thus, the O-GlcNAc ... 670–7 11) and not in the DNA-binding domain (Fig. 6). These results provide another convincing example highlighting the AB Fig. 7. The glycosylated t runcated forms...

Ngày tải lên: 30/03/2014, 15:20

... DP9-overexpressing cells of the ECM-interacting molecules discoidin domain receptor 1, a kinase activated by collagen binding, and the MMP inhibitor, tissue inhibitor of matrix metallopro- teinase-2, ... for different cancers. Further understanding of the biologi- cal anti-invasive effect of DPIV in vitro could be of importance in the control of certain carcinomas. FAP distributio...

Ngày tải lên: 06/03/2014, 09:22

... [45,46]. SDS–PAGE analysis of the purified proteins indicated that they contained < 5% contaminating proteins. The concen- trations of proteins used in these studies were determined by spectrophotometric ... stacking interactions of arginine and aromatic side-chains in proteins. J Mol Biol 235, 709–717. 43 Lindner RA, Treweek TM & Carver JA (20 01) The molecular chaperone a-c...

Ngày tải lên: 18/02/2014, 16:20

... keep the mass cen- tre of the protein (marked with a black dot in Fig. 4) onto the axis z, and (b) to conserve the minimal distance between protein and membrane at 3.5 A ˚ . The EIE, i.e., the ... proteins, with high isoelectric point values. Thus we investigated the effects Table 1. Natural and engineered RNases investigated in this study. IC 50 is the RNase concentrati...

Ngày tải lên: 19/02/2014, 06:20

... N-linked oligosaccharide side-chains are important for the GABA transport activity. 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal ... for the stability of this protein, but the terminal structure of the N-glycans is not. Defective N-glycosylation reduces the trafficking of GAT1 to the plasma membrane...

Ngày tải lên: 19/02/2014, 17:20

... produc- ing information about the opinions that a document contains; for instance, Morinaga et al. (2002). In March, 2004, the American Association for Artifi- cial Intelligence held a symposium in this ... class: linear estimates for the logit. This understanding facilitates further extensions, in particular, utilizing the following: 1. Labeled documents 2. More anchor words Th...

Ngày tải lên: 20/02/2014, 16:20

... accomplish the selective charge–charge interaction. The presence of an additional histidine residue in the prolyl 4-hydroxylase binding site may be required to maintain the lysine side-chain in a positively ... 2-OG. The difference in the levels of coupling between 2-OG and penicillin G or ampicillin oxidation is probably a reflected in the apparent K m values for these...

Ngày tải lên: 20/02/2014, 23:20

... in the table using the ~-expression, and then finding the corresponding element in the model. If the element in the model that was the denotation of the h-expression was not expanded in the ... Mechanisms are introduced to eliminate these local (temporary) inconsistencies, but the most natural mechanism can introduce permanent inconsistencies in the inf...

Ngày tải lên: 21/02/2014, 20:20

... necessary; in this case, it is precisely the end point of the building event that coincides with the beginning of the event of the house being new. In a system using Allen's primitives, the ... tion that the cake is warm while John is frosting it, the time span during which the cake is warm must include the time 3:00; however, the starting and end...

Ngày tải lên: 21/02/2014, 20:20

... BLSa' ] is the distinguished child of ALSa ]. Given a derivation, the distinguished de- scendant relation is the reflexive, transitive closure of the distinguished child relation. The language ... node. In 7 t the nodes contributed by/3 have the same constraints as those associated with the corresponding nodes in/ 3. The remaining nodes in 7 ~ have the...

Ngày tải lên: 22/02/2014, 10:20