Báo cáo khoa học: Structural and functional analysis of ataxin-2 and ataxin-3 potx

... concentration of its product and the sensitivity of the rate of the demand module to changes in the concentration of its sub- strate, respectively. In the case of mean elasticity coefficients, p i and S both ... concentration of the intermediate, S, and measure the rates of the supply and demand modules, v 1 and v 2 . Applying fitting procedures to the table of experim...

Ngày tải lên: 30/03/2014, 10:20

... mapped onto the LRR and AXH domain of Anp32 and Atx1 respectively, and was shown to be stronger for expanded Atx1 [16,18]. The temporal and cell-specific expression pattern of Anp32 in cerebellar ... regions of the molecule. As part of a long-term function-oriented structural effort aimed at understanding the molecular bases of polyQ disease proteins, we report here a study...

Ngày tải lên: 18/02/2014, 17:20

... for each edge of the graph. 6: Refine the scores  S 1 and  S 3 of the k 2 sentiment and topic word candidates using Eqs. (5) and (6) iteratively. 7: Select k 1 new sentiment words and k 1 new ... set of nodes represents topic words, including new topic candi- dates and words in the lexicon C, and the other set of nodes represents sentiment words, including new sentiment c...

Ngày tải lên: 19/02/2014, 19:20

... needed for direct measurement of holo-TC in serum. The antigenic determinants and the functional domains of TC have not been identified. Cloning [5–7] and recent expression of several kind- red Cbl-binding ... absence of S-S bonds and the low number of conserved residues in this part of the sequence. Only later did the large N-terminal unit become involved in the binding o...

Ngày tải lên: 20/02/2014, 01:20

... features of the LPO and MPO catalytic cycle, such as the existence of Compound I and Compound II isomers and the identification of their spectroscopic properties. After addressing each of these ... the catalytic cycle of two mammalianperoxidases,LPOandMPO,inorderto reconcile the apparent inconsistencies and to provide some new insights. MPO and LPO share functional and...

Ngày tải lên: 20/02/2014, 02:21

... the majority of its activity over the same time period. CD analysis of PrP mutants In order to determine if deletion of critical regions of PrP caused loss of activity because of structural alterations, ... activity of PrP. Production of deletion mutants of PrP On the basis of the results with antibodies, a series of PrP mutants were made to assess whether deletions...

Ngày tải lên: 21/02/2014, 00:20

... transcription–PCR analysis of unknown serial analysis of gene expression tags; rSAGE, reverse serial analysis of gene expression; SAGE, serial analysis of gene expression; TSAT-PCR, two-step analysis of unknown ... PCR analysis of unknown tags on serial analysis of gene expression Wang-Jie Xu 1 , Qiao-Li Li 1 , Chen-Jiang Yao 1 , Zhao-Xia Wang 1 , Yang-Xing Zhao 1...

Ngày tải lên: 07/03/2014, 04:20

... different syntactic constraints of the two languages. We present a contrastive analysis of the syntactic realizations of possessives and par- titives in Hebrew and English and conclude by presenting ... 1994)): measure a mile of cable, typical partitives a loaf of bread, a slice of cake, and general partitives: a piece/bit /of an item of X. In the syntacti...

Ngày tải lên: 08/03/2014, 06:20

... within the framework of metabolic control analysis (MCA) [1–5]. Metabolic networks of organisms show thousands of variable concentrations and fluxes, so full application of traditional MCA to ... definitions of the coef- ficients in Doc. S1 and [21]). The number of response coefficients in cellular metabolism (number of parame- ters · number of variables) is very large, and...

Ngày tải lên: 14/03/2014, 23:20

... approach would be the early recognition of ‘off target’ and side effects of drug candidates [7], as well as the identifica- tion of putative biomarkers. The phosphorylation status of signaling pathway components ... dynamic aspects of pathway events and (d) the profiling of compounds to reveal signaling and cross-pathway effects of drug candidates. In addi- tion, analysis...

Ngày tải lên: 16/03/2014, 00:20