Báo cáo khoa học: Tyrosine phosphorylation of calponins Inhibition of the interaction with F-actin pot
Báo cáo khoa học: Tyrosine phosphorylation of calponins Inhibition of the interaction with F-actin pot
... increased their phosphotyrosine content. The lack of F-actin protection against tyrosine phosphorylation of calponins contrasts with the F-actin- induced blockingeffect on the enzymatic Ser/Thr phosphorylation ... functional effects of its phosphorylation relative to those found with the two other calponins. Next, we examined the influence of F-actin on the extent of phosphorylation of calponin h1 and calponin ... villin with F-actin has beenreported previously [16]. The association of F-actin with either calponin h1 or h3 during the kinase reaction did nothinder the phosphorylation process of the calponins; however,...
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Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
... threonine phosphorylation of tau [20,21]. To determine whether the tyrosine phosphorylation status of tau also affects the binding of tau to Fyn-SH3, CHO cells werecotransfected with Fyn together with ... increased tyrosine phosphory-lation in cells.Tyr18 of tau plays an important role in the interaction of tau with Fyn-SH2To determine whether the tyrosine phosphorylation status of tau itself ... Fyn-dependent. As wefound that the tyrosine phosphorylation of tau influ-ences its interaction with Fyn, we therefore set out toinvestigate the role of tyrosine phosphorylation inintracellular...
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Tài liệu Báo cáo khoa học: Substrate specificity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria brassicicola ppt
... eluted with 55 mL of the same buffer, first alone and then with a200 mL of a decreasing gradient of ammonium sul-phate in 20 mm Tris⁄ HCl buffer (pH 8.0) with a flow of 0.8 mLÆmin)1. Fractions of ... 97% inhibition of BHLmL2 and BHAb, respectively. The influence of pH on the activities of the BHenzymes was investigated in the pH range 6–11. The pH optima were determined to be in the basic range(pH ... andBHAb. The temperature dependence of the activities of the BHs was tested in the range 5–56 °C; the apparentoptimum temperatures of BHLmL2 were 25–30 °CTable 3. Masses and scores of tryptic...
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Báo cáo khoa học: Cell biology, regulation and inhibition of b-secretase (BACE-1) potx
... in the interaction with the BACE-1 cytoplasmic domain [74]. The cellularform of the prion protein also negatively regulatesb-secretase cleavage of APP, probably through its raft interaction with ... small peptidesubstrates as they lack many of the subsite and otherinteractions of the genuine protein substrate. Neverthe-less, such studies have led to the development of novelBACE-1 inhibitors, ... of the zymogen couldbe explained by the high mobility of the prosegment incomparison with that of other zymogens, resulting in the occasional exposure of the catalytic site for accessby its...
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Báo cáo khoa học: Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction pdf
... [20,21]. The ability of farnesol administration to alter the prenylation of the small G proteins Ras and Rap1A has been previouslytested and neither the prenylation event nor the ability of the G ... role of phospholipids in the PLDsignaling pathwayWe next determined the ability of PC (upstream of the alcohol block) and DAG (downstream of the alcoholblock of PLD) to rescue cells from the ... by the exogenous addition of theseFig. 1. DAG consumption for the synthesis of PC and PLD medi-ated turnover for the generation of a DAG-signaling pool. DAG util-ization during the synthesis...
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Báo cáo khoa học: "How do you pronounce your name? Improving G2P with transliterations" potx
... terms to the phonetic transcription of the second output in the n-best list, as compared to the other outputs. One obvious problem with thismethod is that it ignores the relative ordering of the n-best ... are caused by a lack of evidence for the map-ping of the grapheme representing the sound /k/in the transliteration training data with the phoneme/Ù/. In addition, the lack of alignments prevents ... way into the re-ranking; the process is basedpurely on the transliterations and their similarities with the transcriptions in the output lists, indicat-ing that the system is capable of extracting...
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Báo cáo khoa học: "A Voice Enabled Procedure Browser for the International Space Station" pot
... step 6. If the user subsequentlygoes past step 17 of the subprocedure, the systemwarns that the user has gone past the required steps,and suggests that they close the procedure.Other important ... itjumps directly to the next section. Step 51 points the user to a subprocedure. The spoken version asks if the user wants to execute the steps of the subproce-dure; if so, it opens the LCVG Water ... to improve the decision quality by also takingaccount of the information in the recognised words.By thinking of the confidence scores as weights,we can model the problem as one of classifying...
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Báo cáo khoa học: "Lexical Transfer based on bilingual signs: Towards interaction during transfer" potx
... translations of source lexical items has been one of the hardest problems in MT. Because languages have their own ways of reflecting the structure of the world in their lexi- cons, and the process of ... [WEAR:MI-NI-TSUKERU] and if the argument-2 of the event belongs to the sort [SHOES:KUTSU], then the event also belongs to [WEAR:HAKU]. All the event-sorts related with wear in the above have the same argument ... though the adverb nanwka is not the head of the Japanese deep case description ('jpn'), it is converted into the predicate [MANAGE:NANTOKA] in the logical formula, and the rest of the...
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Tài liệu Báo cáo khoa học: Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF65 doc
... basis for the effect of SPSP motif phosphorylation on the interaction of SF1 with U2AF65.A comprehensive set of data supports the functionalimportance of the interaction of SF1 with U2AF65.Inmammals, ... suggesting that phosphorylation of these sites might regulate the formation of the SF1-U2AF-RNA complex. We first tested the effect of phosphorylation on the interaction of SF1 with U2AF65by ... a marked shift of the SF1fband on SDS ⁄ PAGE (Fig. 3A). The interaction of the UHM domain of KIS with SF1 appears to be import-ant for efficient phosphorylation, as deletions withinthis domain...
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Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt
... affinity of the binding interactions was evaluated by measuring the changes of fluorescence polarization of the peptides ateach step of titration with the Grb4 SH2 domain, i.e. the binding isotherms ... details of these signaling events have yet to beinvestigated, many of the molecular interactions down-stream of the Eph and ephrin molecules appear to lead to the regulation of the cytoskeleton of ... phos-phatases. On the other hand, tyrosine phosphorylations donot affect the conformation of the PDZ binding motif at the C-terminus (Fig. 9). Therefore, the 33-residue functional tail of ephrin B2...
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