Báo cáo khoa học: The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein ppt
Báo cáo khoa học: ‘Big frog, small frog’ – maintaining proportions in embryonic development Delivered on 2 July 2008 at the 33 rd FEBS Congress in Athens, Greece pot
... is the presence of two BMP ligands, with the affinity of Admp to the inhibi- tor Chordin much lower than the Bmp4–Chordin affinity. The presence of two ligands competing for the binding of Chordin ... mechanism. The inhibitor, Chordin, binds the immobile BMP ligands and forms a diffusible complex, effectively carrying the ligands. The complex is then cleaved by th...
Ngày tải lên: 30/03/2014, 02:20
Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... in obese mice In order to gain insights into the potential biologically relevant role of miR-27 in the regulation of adipose tis- sue functions in vivo, we examined the expression of miR-27 in ... together, these results illustrate a critical and specific role of miR-27 in the regulation of adipogenic differentiation. miR-27 prevents the induction of PPA...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing action of the cytosolic RNase inhibitor, a resistance due to the dimeric structure of the enzyme. ... exerted when the protein reaches the cytosol of the affected cells, where it degrades ribosomal RNA, thus blocking protein synthesis and leading c...
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx
... molecule comprising Ôresidues in the protruding domain consisting of the type VI b-turn and the first part of b-strand 3Õ (i.e. the b-hairpin loop and part of the adjoining b-sheet) and Ôresidues in the loop ... obtained by other groups who also point to the role of the connecting loop of the b-hairpin of defensins. A combination of mutational analys...
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... deviates from the original position. In the struc- tural deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-chain at residue 169 (Table 1 and Fig. ... effect of the size of the residue at position 169 may be related to the solvent accessibility of the side-chain of His210 (Fig. 3C). When the accessib...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx
... regulated similarlyinyeastandinadrenalcells;inthelatter,Adxpand not Adrp limits the activity of CYP11A1 and hence controls the extent of pregnenolone production [14]. Protein partners involved in the yeast ... mutation(s) in the steroidogenic acute regulatory protein (StAR) protein correlate(s) clearly with the absence of pregnenolone synthesis. The well-characte...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf
... last amino acids in the C-terminus of MaL. Deletion of the four last amino acids strongly reduced the expression of the protein in T. reesei and S. cerevisiae. Further- more, the deletion resulted in ... expressed both in yeast and in T. reesei, was practically inactive. Also, the kinetic parameters were altered. The change of only one amino acid in th...
Ngày tải lên: 16/03/2014, 00:20
Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt
... signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins with the ATM-related kinase, ATR, and the ... activation of the S-phase checkpoint. The Mre11-bind- ing domain is responsible for binding to Mre11 during formation of the Mre11–Rad50–Nbs1 (MRN) complex. The AT...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo khoa học: Functional role of the linker region in purified human P-glycoprotein pot
... containing P-gp, the results could be affected by other proteins. In fact, it was reported that the linker region of P-gp interacts with other proteins such as RING finger protein 2 (RNF2) [25] and ... (2006) RNF2 interacts with the linker region of the human P-glycoprotein. Int J Oncol 29, 1413–1419. 26 Georges E (2007) The P-glycoprotein (ABCB1) linker domain encodes high...
Ngày tải lên: 29/03/2014, 23:20
Báo cáo khoa học: Functional role of Bb-chain N-terminal fragment in the fibrin polymerization process pdf
... situated in the E-domain of the fibrin molecule, the complementary site ‘c’ is suggested to be situated in the D-domain. We have tried to model the intermolecular binding between the D-domain of one ... (A,B,C) and 180 s (D,E,F) from the start of the process: (A,D) in the absence the synthetic peptides; (B,E) in the presence of Bb12–26 peptide; and (C,...
Ngày tải lên: 30/03/2014, 03:20