Báo cáo khoa học: Oxidative neuronal injury The dark side of ERK1/2 potx

... MINIREVIEW Oxidative neuronal injury The dark side of ERK1/2 Charleen T. Chu 1,4 , David J. Levinthal 3,4 , Scott M. Kulich 1 , Elisabeth M. Chalovich 1 and Donald B. DeFranco 2,3,4 1 Department of Pathology, 2 Department ... regulating ERK1/2 signaling through effects on scaffolding functions of b-arrestins, or by modulating the activity of protein kinase C, which c...

Ngày tải lên: 30/03/2014, 13:20

... the relationship of these two molecules is still largely unknown. The aim of the current study was to investigate the potential involvement of nucleolin ⁄ C23 in the antiapoptotic mechanism of Hsp70. ... the condensation and fragmentation of their nuclei. The percentage of apoptotic cells was calculated as the number of apoptotic cells divided by the total numb...

Ngày tải lên: 16/02/2014, 09:20

... a standard light ⁄ dark cycle (lights on at 07:00 h). The experiments were performed according to the Guide for the Care and Use of Laboratory Animals of the US Department of Health and Human ... not die within 24 h of observation. Determination of lipid peroxidation and nitrite content For all of the experimental procedures, 10% (w ⁄ v) homo- genates of the area...

Ngày tải lên: 19/02/2014, 16:20

... importantly, the influence of oxidative stress on these processes. Our data clarify some of these aspects, and suggest that thiol-directed oxidative stress consider- ably influences the inter-organ ... two- step reaction catalyzed by the enzymes c-glutamylcyste- ine synthetase and GSH synthetase. The supply of Cys is directly related to the rate of GSH synthesis, because...

Ngày tải lên: 16/03/2014, 02:20

... understand the biological significance of the differ- ence in TnI–TnC interactions, we compared the ability of TnC to neutralize the inhibitory effects of the C-ter- minal fragments in the presence ... ATnI 1)128 exhibited a band near the origin and at the middle of the gel, respectively. The bands corresponding to the free rabbit or Akazara scallop TnC were found...

Ngày tải lên: 20/02/2014, 01:20

... returns true if the morph of the descendant of d e is the same as the morph of the descendant of d s , or if both descendants have canonical mentions with an exact string match; the 3 We remove ... parse trees. The set of nonterminal labels associated with each word is the set of labels of the nodes for which that word was the head. For example, in the lexi...

Ngày tải lên: 20/02/2014, 09:20

... to the magnesium binding site M3 [4]. Fig. 4. The influence of Mg 2+ on the kinetic properties of APase from E. coli. The influence of Mg 2+ on the kinetic properties of APase from E. coli inthepresenceofaZn 2+ to ... influence the equilibrium concentration of the subunits. Deviation from linearity in the dependence of the Mg 2+ ion concentration It has been determi...

Ngày tải lên: 21/02/2014, 00:20

... dimethylsulfoxide-facilitated entry of saporin into the cytosol. The LEX2 inhibition of cargo delivery to the late endosomes would thereby increase the pool of saporin available for passage from the early endosomes ... disrupt the integrity of endosome mem- branes [13,14]. Neither reagent generated comparable levels of cellular sensitization to AB toxins or to the isol...

Ngày tải lên: 07/03/2014, 05:20

... also considerable debate regarding the role of the ClpB N-domain (which shares a common fold with the N-domain of ClpA) in substrate selection [15–17]. One difficulty in understanding the role of the ... initiated through productive binding to the substrate via two elements in ClpA, one in the N-domain and the other in the pore of the ClpA hexamer. In the case of...

Ngày tải lên: 07/03/2014, 05:20

... taken to be the subject of the clause. This ap- plies to about half of all the instances where the function of the relative pronoun is ambiguous. 2. On the other hand, if the form of the sub- ... be made by the position of the verb because of the rule that in a subordinate clause the verb must normally come at the end. How, then, are we to deter- m...

Ngày tải lên: 07/03/2014, 18:20