Báo cáo khoa học: Searching for folded proteins in vitro and in silico docx

... MINIREVIEW Searching for folded proteins in vitro and in silico Alexander L. Watters 1 and David Baker 2 1 Molecular and Cellular Biology Program and 2 Department of Biochemistry and Howard ... succes- ses in generating novel proteins using in silico protein design. Keywords: loop entropy; mini-exon shuffling; phage- display; protein evolution; random sequences...

Ngày tải lên: 30/03/2014, 13:20

... identifying question topic and question focus for search significantly outperforms the base- line methods such as Vector Space Model (VSM) and Language Model for Information Retrieval (LMIR). 1 Introduction ... during winters? 2. How long and cold are the winters in Rochester, NY? 3. How cold is it in Alaska? LMIR 1. How cold is it in Alaska? 2. How cold does it get...

Ngày tải lên: 17/03/2014, 02:20

... Our intention is to employ these virtual concepts in document indexing. In this paper we show some preliminary experimental results and discuss direc- tions of future work. 1 Introduction In the ... in a training collection. The task of -optimization leads to a system of linear inequalities, which we solve via linear program- ming. As there is no scope for this issue here, we cann...

Ngày tải lên: 08/03/2014, 04:22

... therefore clarified the binding site of the menaquinols, but for technical reasons it cannot reveal the site for the ubiquinols, because HOQNO does not inhibit binding of the ubiquinols. Kinetic studies ... single quinol-binding site. However, the technique used to determine binding sites of quinols, inhibition by HOQNO (a structural analogue of menaqui- none), did not allow them to see th...

Ngày tải lên: 07/03/2014, 15:20

... framework for interlinguas, rather than one universal interlingua. This makes the interlingual approach more light-weight and feasible than in systems assuming one universal interlingua, such ... structures and distinctions that are relevant for the task at hand. Thus an interlingua for mathematical proofs (Hallgren and Ranta 2000) is different from one for commands for oper...

Ngày tải lên: 17/03/2014, 00:20

... descriptions is construc- ted using only addition transformations, and pointer movement transformations (called "pops" in tinde and Goguen (1978)) which bring the focus of attention back ... those portions in which the president and his advisors engage in the activity of planning. (Linde and Goguen, 1978). Planning sessions form a discourse unit with "[ In...

Ngày tải lên: 17/03/2014, 19:20

... tradition in statistics, engineering and life sciences, dating back to the beginning of the last century when optimal designs for industrial and agricultural trials were considered. In cell biol- ogy, ... techniques allowing for quantitative measurements and the pro- ceeding level of knowledge in cell biology allows the application of mathematical modeling approaches for tes...

Ngày tải lên: 23/03/2014, 06:20

... in training data and test data; then the remaining samples will be used as input of a maximum entropy tagger. The features used in this tagger involve distance, string matching, lexical information, ... global information for name tagging. (Borthwick, 1999) made a second tagging pass which uses in- formation on token sequences tagged in the first pass; (Chieu and Ng, 2002...

Ngày tải lên: 23/03/2014, 19:20

... S 1 //S 2 and S 2 //S 3 , then S 1 //S 3 . It was thus considered sufficient to indicate the in- dex of S 1 for S 2 and the index of S 2 for S 3 to account for a parallelism between S 1 , S 2 and S 3 . We ... cabcad and S 2 = acbae, along with their subsentences s 1 = caba and s  1 = abca for S 1 , and s 2 = acba for S 2 . The degrees of parallelism between s 1 and s...

Ngày tải lên: 24/03/2014, 03:20

... synthesis of proteins in the presence of other pro- teins provided in excess at the start of or during the reaction, e.g., for the purpose of rescuing nascently produced insoluble proteins into soluble ... starting materials are used more efficiently and economically than for conven- tional in vivo labelling methods [7]. (d) The reaction is independent of cell growth. Therefore...

Ngày tải lên: 07/03/2014, 12:20