Báo cáo khóa học: NF-jB- and c-Jun-dependent regulation of human cytomegalovirus immediate-early gene ppt

... ARTICLE MicroRNAs and the regulation of fibrosis Xiaoying Jiang 1,2 , Eleni Tsitsiou 2 , Sarah E. Herrick 2 and Mark A. Lindsay 2 1 Department of Genetics and Molecular Biology, School of Medicine, ... reasons, and knowing the multitude of pathways that miRNAs can affect, it is envisaged that investigating the roles of miRNAs in fibrosis could not only advance our understand...

Ngày tải lên: 15/03/2014, 11:20

... 2009 FEBS 6083 MINIREVIEW Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 Nadja Bitomsky and Thomas G. Hofmann German Cancer Research Center ... etoposide and cisplatin), the levels of Itch become reduced and allow the accumulation of p73 [53]. p73 displays functions in apoptosis induction, and many of its pro-apo...

Ngày tải lên: 16/03/2014, 00:20

... 29, 24 and 12 h at temperatures of 4, 13 and 26.5 °C, respectively. Inhibition of AK by the specific inhibitor Ap5A and its effect on growth of L. donovani promastigotes in vitro The effect of the ... inhibitor of AK, competitively inhibited activity of the recombinant enzymes with estimated K i values of 190 n M and 160 n M for ATP and AMP, respectively. Ap 5 A also in...

Ngày tải lên: 21/02/2014, 00:20

... protein composed mainly of a helices (Figs 1 and 2). The core of Iba2 is a pair of EF-hand motifs, denoted as EF-hands 1 and 2, each consisting of two a helices (aA, aB and aC, aD, respectively) ... cross-linking efficiency of Iba1 and Iba2 or in the overall morphology of the generated filament bundles. Calcium affinity of Iba1 and Iba2 Homodimerization and actin bindin...

Ngày tải lên: 16/03/2014, 06:20

... length of introns among different species and between gene family members of the same plant; and (b) the absence of one intron in the A. thaliana genes AtPaspA2 and At- PaspA3 [29]. Cardosins and ... stages of the plant life cycle [16–21]. In this study, the genomic sequences of the cardo- sin A and B genes and of two new cardosin genes (those encoding cardosins C a...

Ngày tải lên: 30/03/2014, 09:20

... Department of Biology and Biochemistry, University of Bath, UK 2 Department of Biochemistry, University of Wisconsin–Madison, USA 3 Department of Chemistry, University of Wisconsin–Madison, USA Introduction Upon ... studies of the structure and binding sites of enzymes. 8. Inhibitor binding to ribonucleases. J Mol Biol 45, 491–511. 33 Ui N (1971) Isoelectric points and c...

Ngày tải lên: 14/02/2014, 22:20

... structure of cN-II showing interfaces A and B and the Mg 2+ site. The inset shows the tertiary structure of each subunit. Effector sites 1 and 2 and the active site are shown. Table 2. Effect of point ... transfer of phosphate esterified in the 5¢ position of 6-hydroxypu- rine monophosphate nucleosides [1]. The transfer of phosphate can lead to phosphorylation of inosine,...

Ngày tải lên: 15/02/2014, 01:20

... characterization of numerous com- plexes of the human HPRT and several bacterial and protozoan HPRTs have been undertaken [13–17]. The structure of human HPRT can be divided into two domains: a core domain and ... HPRT and hypoxanthine. (C) PRTFDC1 and guanine. (D) HPRT and guanine. Table 2. K m and V max values for Hx and G in the presence of 1 mM PRPP, determined...

Ngày tải lên: 15/02/2014, 01:20

... performed using T-COFFEE [44]. Docking simulation of substrate on the active site of HYD Js The substrate binding pockets of HYD Js and the mode of interaction between substrate and enzyme were ... fluorescens PfO-1 and S. coelicolor A3(2). Cloning and expression of the putative hyd genes The deduced open reading frames of putative hyd genes were PCR-amplified from the genom...

Ngày tải lên: 18/02/2014, 08:20

... an accurate measure of the k off parameter in CaM-bound eNOS and nNOS [58], and thus prevented assessment of the relative importance of conformational change rates versus rates of FMNH 2 formation ... Model and simulations of cytochrome c reduction by NOS enzymes. (A) Scheme of cytochrome c reduction. The model uses four kinetic rates: dissociation (k 1 ) and association (...

Ngày tải lên: 18/02/2014, 11:20