Báo cáo khóa học: Genetic approaches to the cellular functions of polyamines in mammals potx

... with induced expression of insulin-like growth factor binding protein-2 in the uterus and ovary and decreased expression of insulin- like growth factor binding protein-3 in the uterus. These changes ... biosynthesis, as DFMO retards the growth of the pancreas [101], but does not inhibit the secretory function of the exocrine part of the organ [102]. The cellular...

Ngày tải lên: 30/03/2014, 13:20

... treat- ment of A549 cells with increasing concentrations of the Sp1 inhibitor mithramycin A (Fig. 3B), which not only interferes with the transcription of genes containing GC-rich regions in their ... lines to the p73 P1 promoter In order to validate the ability of endogenous Sp1 to bind to the p73 P1 promoter within the cellular environment, we performed add...

Ngày tải lên: 29/03/2014, 09:20

... provides some interest- ing insights on the role of elements of the caption. There appear to be two primary functions of verbs. The first is to reflect what is in the data, thereby strengthening the message ... understand- ing the meaning of riding high in the polls. Another example is “Bad Moon Rising”; here the verb ris- ing suggests that something is increas...

Ngày tải lên: 08/03/2014, 04:22

... corresponds to the views of an exten- sion and constrains the number of intensions to one by using the function '!1' introduced in Section 4.1 as shown in the following; which is indistinguishable ... kind of verb phrase. Then, as in the ease of the English copula, the se- mantics of the Japanese copula is "transparent." Thus, the...

Ngày tải lên: 08/03/2014, 06:20

... drugs. Megalin is involved in the endocytic uptake of a number of vitamin carrier proteins [18], including retinol binding protein [19], transcobalamin [20], and vitamin D binding protein [21,22] ... related member of the LDL-receptor family [25]. To confirm binding of FBP to megalin in tissues we used autoradiography on sections of rat kidney cortex showing very high exp...

Ngày tải lên: 30/03/2014, 20:20

... model the P-selectin-binding domain of the mucin-like glycoprotein PSGL-1 [73,74]. This ligand is involved in the initial homing of leuko- cytes to sites of in ammation [73,74]. The binding of PSGL-1 ... consequence of the lack of direct genetic control of their biosynthesis, natural PTMs vary in site and level of incorporation, leading to mixtures of mo...

Ngày tải lên: 18/02/2014, 17:20

... idea was to combinatorially design proteins de novo by inserting random sequences into a loop of the SH2 domain and screening for binding to the phosphotyrosyl ligand peptide [67]. In principle, ... that the orientation of the Fig. 5. Domain swapping and other quaternary rearrangements in pro- tein G B1 domain and rop. Top: Mutagenesis of five residues in the core of...

Ngày tải lên: 19/02/2014, 12:20

... raises the question Ôhow do the a-conotoxins bind to the different nAChR subtypes?Õ,as they are of intermediate size. a-Conotoxin docking modes on neuronal nAChRs a-Conotoxin binding sites Of the ... ACh binding site (and the docking simulation of ligands) because loop C of the b subunit is not involved in the competitive binding site [16]. Finally, the important r...

Ngày tải lên: 19/02/2014, 12:20

... automatic indexing systems using sophisticated term weighting systems to assess the importance of the indexing units. [Salton 1975a, 1975b] By joining the available linguistic procedures with the ... output. Thus in Fig. 3, the VERB is the main head of the sentence; the head of the noun phrase preceding the main verb is the NOUN representing the term &...

Ngày tải lên: 08/03/2014, 18:20

... has three in- puts: the total word similarity, the cosine similarity between the sum of the answer word vectors and the sum of the rest of sentence’s word vectors, and the number of out -of- vocabulary ... any of the individual models. To better understand the system performance and gain insight into ways of improving it, we have ex- amined the system’s err...

Ngày tải lên: 16/03/2014, 19:20