... [12]. The products of these three genesare known, respectively, as the small (p42/p46), the medium(p69/p71) and the large (p100) forms of OAS [13], all of which are enzymatically active. The ... preylibrary from human leukocyte cDNA fused to the trans-activating domain of GAL4. The yeast strain L40 was used for screening the library, enabling selection of bait and preyplasmids by the TRP1 and ... critical for the covalent conjugation of Ub and UbLto cellular proteins [17]. Accordingly, the role of the p59OASL UbL is, as yet, unknown.An orthologue of p59 OASL exists in mice that, like the human...