Báo cáo khoa học: Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases Retinoic acid-induced upregulation of substrate and proteinase ADAM10 during neuronal cell differentiation ppt
Báo cáo khoa học: Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases Retinoic acid-induced upregulation of substrate and proteinase ADAM10 during neuronal cell differentiation ppt
... FEBS Shedding of the amyloid precursor protein- like protein APLP2 by disintegrin-metalloproteinases Retinoic acid-induced upregulation of substrate and proteinase ADAM10 during neuronal cell differentiation Kristina ... cleavage of the mammalian APP-related protein APLP2 by the disintegrin and metalloprotein- ases ADAM10 and TACE...
Ngày tải lên: 30/03/2014, 11:20
Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf
... explain the dimerization of the bc 1 complex at this stage (i.e. just after the addition of ISP and Qcr10p). On the other hand, in the transition from the 500 kDa band to the 670 kDa band, a structural ... bc 1 sub-complex, but the presence of only one of these two subunits does not substitute for the other. After the addition of ISP, the binding of the l...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt
... is the lack of domain B protruding out of the TIM barrel in the place of loop 3 connecting the b3-strand to the a3-helix [9,21]. Sharing domain B by rBATs and GH13 enzymes, and especially the ... subfamily together with the intermediary enzymes (Fig. 1). The overall arrangement of the tree is that the clusters of true rBAT and 4F2hc proteins are separated...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide doc
... iden- tify the nature of the enzyme and provide additional information about the evolution of the ChEs, including the origins of the acyl pocket, the T exon, and the asymmetric forms of ChE in the vertebrates. Results The ... illustrates the differences between the construction of the acyl pocket in vertebrate and invertebrate AChEs. The line separa...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt
... illustrates the quality of the experimental data (Fig. 2B). Reconstruction of the overall shape of the PLDa2 from the X-ray scattering data was achieved by the ab initio modeling program dammin [24]. The ... nm; and (b) a wide minimum between 208 and 220 nm. The a-helix and b-strand contents of the protein were calculated with the online programs dichrowe...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... levels of HO-2 mRNA and protein in five out of six cell lines, with the exception of KG1 myeloid cells. Hypoxia decreases the expression levels of HO-2 protein in YN-1 and K562 cells To confirm the ... HO-2 mRNA in YN-1 cells To explore the mechanism of the hypoxia-mediated reduction of HO-1 and HO-2 protein levels, we ana- lyzed the effects of hypoxia on...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina doc
... The tagged protein had a similar activ- ity in the crude extract as the nontagged protein, indi- cating that the tag did not affect the protein activity. The tagged protein was then purified and ... interfering with the protein activity. The tagged protein was purified and then used for further analysis. In the reductive reaction, the Michaelis–Menten con- sta...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc
... (strands bC–bG) facing the interior of the phage particle, with an N-terminal hairpin (strands bAandbB) and two a-helices (aAandaB) shielding most of the upper surface of the b-sheet from the ... to the formation of cavities, one in the hydrophobic core (M88V) and the other in the protein RNA interaction (T45S), decrease the stability of the capsid. Our fin...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... IPU consists of a signal sequence (residues 1–19) and a mature part (residues 20–564), and the model is composed of residues 25–540. The overall structure of the model of IPU and the mutated residues ... polysaccharide, pullulan. Comparison of the active sites of the model of IPU and Dex49A The active site structures of t he model of IPU (Fig. 4A) and...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... ana- lysis of the effect was not performed, the inhibition by 20 mm agmatine was eliminated by saturation with l-arginine, indicating the competitive character of the inhibition produced by the substrate ... explained by elec- trostatic repulsion between the a-carboxyl group of the amino acid and the introduced aspartic residue at position 149. On the other...
Ngày tải lên: 20/02/2014, 02:21