Báo cáo khoa học: Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3 docx

... 2553–2562 ª 2006 The Authors Journal compilation ª 2006 FEBS Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3 Isei Tanida, Yu-shin ... it is unclear whether murine Atg8L modification is mediated by human Atg4B, Atg7 and Atg3. Expression of Atg8L in HEK293 cells led to clea- va...

Ngày tải lên: 30/03/2014, 11:20

... probability is equal to the number of occurrences of t, | t |, divided by the total number of occurrences of all subtrees t' with the same root label as t. Let r(t) return the root label of t. Then ... there may be several distinct derivations that generate the same parse tree. The probability of a parse tree T is thus the sum of the probabilities of...

Ngày tải lên: 23/03/2014, 19:20

... tations. Traditionally, the start of intensive work on machine translation is taken as being a memorand~n of Warren Weaver, then Director of the Natural Sciences Division of the Rockefeller Foundation, ... begun in the early 1960's at Grenoble and Milan reflect this, as does the work of the group sot up in Montreal in 1962. These groups based their work f...

Ngày tải lên: 24/03/2014, 01:21

... BiP, PDI and DsbC. To further study the mechanism of action of bacitra- cin, the reduction of insulin was analyzed in the pres- ence of the PDI a domain and DsbA, which are capable of catalyzing the ... neither the specificity of bacitracin for PDI nor the detailed mech- anisms of inhibition of PDI have been investigated. Furthermore, since the original repo...

Ngày tải lên: 16/02/2014, 14:20

... release of the inflammatory cytokine to the same extent. This is in sharp contrast to the effect of rIris on fibrinolysis, an activity lost in the RCL mutant [21]. This indepen- dence of the protease ... and P1¢, which is cleaved by the target pro- tease. This cleavage triggers structural rearrangement of both the protease and the inhibitor in a suicide mechani...

Ngày tải lên: 07/03/2014, 01:20

... characteristics associated with the alarm pheromone biosynthesis. We also report the nucleotide and amino acid sequences of Car. lactis GeDH. On the basis of the comparison of enzymatic properties and ... different from that of Car. lactis GeDH. The results from this study suggest that Car. lactis GeDH specializes in the biosynthesis of neral, the alarm pheromone...

Ngày tải lên: 16/03/2014, 06:20

... using CLUSTAL W .(A) The start residue of the BCCP-87 domain and the BCCP subtilisin fragment are indicated (fl and Ñ, respectively). The start codon of the BCCPD67 domain is shown (›), and the biotinylated ... °Cfor30min. Digestion was terminated by the addition of SDS sample buffer and boiling for 5 min. The extent of proteolysis was analysed by SDS/PAGE...

Ngày tải lên: 31/03/2014, 07:20

... [34]. Therefore, we propose that the lack of enzymatic activity is a result of the presence of a high concentration of TIMP-2 in the conditioned medium of COS-1 cells. This was also supported by our ... levels of MT-MMPs. Furin is localized predominantly in the TGN, but some is present at the plasma membrane [21,22,25]. This enzyme is also secreted by cells...

Ngày tải lên: 16/03/2014, 00:20

... used by parsing the New York Times (NYT) section of the Gigaword (Graff and Cieri, 2003) cor- pus using the Berkeley Parser (Petrov and Klein, 2007; Petrov, 2010). Table 1 lists the NP length distributions ... across a variety of domains, includ- ing (1) the WSJ sections 22-24, and sections com- mensurate in size of (2) the SWBD corpus and (3) the Brown corpus. T...

Ngày tải lên: 30/03/2014, 21:20

... characterization of this putative AChE from C. intestinalis should iden- tify the nature of the enzyme and provide additional information about the evolution of the ChEs, including the origins of the acyl ... pocket, the T exon, and the asymmetric forms of ChE in the vertebrates. Results The sequence of the ChE from C. intestinalis suggests that the enz...

Ngày tải lên: 18/02/2014, 17:20