Báo cáo khoa học: Gradual phosphorylation regulates PC4 coactivator function doc

... 277–293. Gradual phosphorylation regulates PC4 function H. R. A. Jonker et al. 1444 FEBS Journal 273 (2006) 1430–1444 ª 2006 The Authors Journal compilation ª 2006 FEBS Gradual phosphorylation regulates ... binding Gradual Masking Model pSER Functional change *** ***** Phosphorylation Chemical Shift Changes SEAC K-RICH B dsDNA (+) PC4 (ctd) 2 dsDNA (+/- , ) K-rich 3 pSer...

Ngày tải lên: 30/03/2014, 11:20

... al. Tyrosine phosphorylation- dependent tau–Fyn binding FEBS Journal 278 (2011) 2927–2937 ª 2011 The Authors Journal compilation ª 2011 FEBS 2937 Tyrosine phosphorylation of tau regulates its ... Price C, Kellie S, Perera T, Zvelebil M, Yang A, Sheppard PW, Varndell IM et al. (2008) Phosphorylation regulates tau interac- tions with Src homology 3 domains of phosphatidylino- sitol 3-k...

Ngày tải lên: 14/02/2014, 14:20

... the cytoplasm as a nucleocytoplasmic shuttling protein and functions in the cytoplasm, whereas F1 stays in the nucleus and executes its function on the nuclear matrix. As previ- ously demonstrated ... 2010 FEBS export signal in the C-terminal. Mutational assays demonstrated that these signals are functional in ATN1 and that deletion or mutation of the nuclear export signal in ATN1 changed i...

Ngày tải lên: 15/02/2014, 01:20

... metastasis, the actual mechanism for the metastasis-promoting function of S100A4 is not com- pletely understood. The protein seems to have several functions, both intracellularly and extracellularly. ... J, El-Gewely SA, Maelandsmo GM, Hovig E, Fodstad O, Loennechen T & Winberg JO (2003) S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells....

Ngày tải lên: 18/02/2014, 11:20

... Inorganic phosphate regulates the binding of cofilin to actin filaments Andras Muhlrad 1 , Dmitry Pavlov 2 , Y. Michael ... motility, including the movement of whole cells, cell division, vesicular transport and exo- and endocytosis. The essential processes of actin dynamics are closely regula- ted in the cell by a large ... most cases by increasing pH [4], and is regulated by phosphatidyl in...

Ngày tải lên: 19/02/2014, 07:20

... incor- porated phosphate most likely corresponds to phosphorylation of other SF1 sites such as Ser20, a known in vivo phosphorylation target [21]. To confirm the major phosphorylation of the SPSP motif, we ... Altogether, this high level of phosphorylation of its SPSP motif indicates a particular involvement in SF1 function. Modulation of SF1 binding properties upon SPSP motif phosp...

Ngày tải lên: 19/02/2014, 07:20

... here that phosphorylation of Tyr304 in the functional C-terminal region (residues 301–333) of ephrin B2 confers high-affinity binding to the SH2 domain of the Grb4 protein. Tyrosine phosphorylation ... tyrosine- phosphorylated peptides. Therefore, our results indicate that the phosphorylations of Tyr311 and Tyr316 identified in vivo may have unknown alternative functions other than physical...

Ngày tải lên: 19/02/2014, 12:20

... Oxygen tension regulates the expression of a group of procollagen hydroxylases Karl-Heinz Hofbauer 1 , Bernhard ... increase the mRNA abundance of the other enzymes. Discussion Our data show that the expression of a functional cluster of hydroxylases enzymes crucially required for procollagen maturation and collagen ... collagen requires the coordinated activities of all the enzymes. Such a...

Ngày tải lên: 20/02/2014, 02:21

... kappa B-alpha proteol- ysis by site-specific, signal-induced phosphorylation. Science 267, 1485–1488. 38 Karin M & Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-jB ... Methods 26, 37–47. NF-jB regulates protein tyrosine kinase Tec L. Yu et al. 6724 FEBS Journal 276 (2009) 6714–6724 ª 2009 The Authors Journal compilation ª 2009 FEBS NF-jB regulates the...

Ngày tải lên: 07/03/2014, 00:20

... that formation of the cofactor–substrate fVIIIa– fX complex regulates the rate of fX activation. This study suggests an additional function for fVIIIa in providing high-affinity binding sites ... with labeled factors. (A) Binding of fIXa–EGR as a function of bound fVIII, added at a concentration from 0 to 256 n M (B) Binding of fIXa–EGR as a function of bound fVIIIa, added at a concent...

Ngày tải lên: 23/03/2014, 11:20