Báo cáo khoa học: Ataxin-3 is subject to autolytic cleavage potx

... 21, 89–92. Autolytic cleavage of ataxin-3 P. L. Mauri et al. 4286 FEBS Journal 273 (2006) 4277–4286 ª 2006 The Authors Journal compilation ª 2006 FEBS Ataxin-3 is subject to autolytic cleavage Pier ... conclude that AT-3 activity is not caspase-like. The ability of AT-3 to undergo autolytic degradation might be related to the mechanisms of pathogenesis, as proteolysi...

Ngày tải lên: 30/03/2014, 10:20

... similar to the corresponding preimmune yolk and was not used for further immunohistochemical studies (data not shown). Immunohistochemistry and confocal laser scanning microscopy were used to determine ... in the pathogenesis of autosomal recessive retinitis pigmentosa. J Med Gen 40, e89. 18 Lotery AJ, Malik A, Shami SA, Sindhi M, Chohan B, Maqbool C, Moore PA, Denton MJ & Stone EM (2...

Ngày tải lên: 16/03/2014, 13:20

... intersection of several Arabic dialects. This is dif- ferent from our approach for which POS tagging is only an application. Our focus is to use any exist- ing MSA data to generate colloquial Arabic re- sources ... 4. Related Work To the best of our knowledge, ours is the first work that generates CEA automatically from morpholog- ically disambiguated MSA, but Habash et al....

Ngày tải lên: 07/03/2014, 18:20

... links (dependencies) between words. This is an alterna- tive to constituency parsing, which tries to find a di- vision of the sentence into segments (constituents) which are then broken up into smaller constituents. Dependency ... an item. This is the principle behind the parser defined by Eisner (1996), which is still in wide use today (Corston-Oliver et al., 2006; McDonald et al., 2...

Ngày tải lên: 08/03/2014, 01:20

... lexicalised version of the layer of analysis referred to as discourse. This is in turn a modified version of the story line, where the story line is the succession of all the events in a story, ... Moreover, several stories omit both planning and qualification: this happens in stories where an actor who has provided aid to a successful subject is rewarded, or where he i...

Ngày tải lên: 09/03/2014, 01:20

... specific disabilities (e.g. visual, motor). MELISSA will deliver three main components: a core of linguistic processing machinery and ge- neric linguistic resources for Spanish, English and ... and concatenated into one single unit, it is easy to con- vert them to some code required by the applica- tion. Precisely this latter information is then deliv- ered to the grammar for...

Ngày tải lên: 31/03/2014, 04:20

... USA Macroautophagy (hereafter referred to as autophagy) is a highly regulated process by which the cell degrades portions of its cytoplasm and is distinct from chaperone-mediated autophagy and microauto- phagy ... autophagosomes and cargo by lysosomal proteases [2,3]. The autophagic pathway is crucial for maintaining cell homeostasis and disruption to the pathway can be a contributi...

Ngày tải lên: 07/03/2014, 09:20

... inhibits proliferation and results in delayed entry into mitosis [9]. To address whether this is an isolated function of LIN9 or whether it is medi- ated by LINC, we examined another subunit of ... of LINC with E2F4 ⁄ p130 is disrupted in the S phase. At this time, B-MYB, a member of the vertebrate MYB fam- ily, is incorporated into the complex. LINC–B-MYB binds to and activates t...

Ngày tải lên: 23/03/2014, 04:20

... into some isolated plant mitochondria has been shown to not be robust, as photosynthetic protein precursors like plastocyanin are imported and processed [19,29]. In an attempt to overcome this ... transcripts of mito- chondrial preproteins, directing them to ribosomes in closer proximity to mitochondria [32]. Also in fungi, the acidity of Tom22 at the mitochondrial surface is though...

Ngày tải lên: 23/03/2014, 12:20

... pantotrophus nirF H41M cloned into pEG276 This work pEG276-NirF H41C P. pantotrophus nirF H41C cloned into pEG276 This work pEG276-NirF D129A P. pantotrophus nirF D129A cloned into pEG276 This ... cloned into pEG276 with strep II tag This work pEG276-NirF H41A P. pantotrophus nirF H41A cloned into pEG276 This work pEG276-NirF H41K P. pantotrophus nirF H41K cloned into pEG276 This work pEG276-...

Ngày tải lên: 15/02/2014, 01:20