Báo cáo khoa học: Revisiting the prediction of protein function at CASP6 potx

... of the 3D protein structure. Therefore, the set that was considered contained 64 protein targets, 29 of which had no functional annotation in any data- base at the time of the experiment. A function ... advantage of the knowledge of the identity of the predicting groups as well as of functional annotations that have become available in the mean time. Our...

Ngày tải lên: 30/03/2014, 10:20

... denaturation process. We are unsure of the mechanism of DNA-induced stabilization of the protein, and whe- ther it is related to the normal RNA-binding function of coat protein, as RNA ... methods permitted us to discriminate between the two phenomena inves- tigated here, dissociation of the capsids and denatur- ation of the coat protein. The wild-type coat pro...

Ngày tải lên: 30/03/2014, 11:20

... of these modes are so that one mode activates the other, while the other inhibits the first. The occurrence of the maxima of these two modes is separated in time by one quarter of the period of ... (B) Interpretation of the data discussed in the text. In this panel, the phases of ATP and G6P have been flipped 180°, indicating the relative phases of the mini...

Ngày tải lên: 30/03/2014, 16:20

... of the initial state, the weight of all the tran- sitions, and the final weight of the final state. When several paths in the WFST match the same relation, the total cost is the sum (⊕) of the ... transducers, if the signature for the two states do not match, then they cannot have the same right language and therefore cannot be equivalent. Otherwise, if the t...

Ngày tải lên: 31/03/2014, 03:20

... binding. The other four residues are further away, but at the same side of the protein, indicating a possible additional binding site needed for the WAF1 promoter. Prediction of the severity of mutants ... that look only at stability changes of the mutation compared with the wild-type protein [22,31]. Matthews’ correlation coefficient Matthews’ correlation coeffic...

Ngày tải lên: 18/02/2014, 11:20

... pools gener- ated by the half-reactions. Genetic organization of the nonoxidative branch of the PPP In recent years, the genes encoding the enzymes of the nonoxidative branch of the PPP have ... leading to the formation of either g3p or e4p while leaving behind the bound di- hydroxyacetone (C 3 ). The nitrogen atom of the Schiff base (similar to the nitroge...

Ngày tải lên: 23/03/2014, 15:21

... determin- ing the aggregation state of these proteins. The data therefore support the hypothesis that this N-terminal region is important for modulating the aggregation state of the proteins. In ... the aggregation state of human Sco1 and Sco2 and of their complex with apo-Cox2. It has been proposed that the maturation of Cox2 is contingent upon the formation of a...

Ngày tải lên: 14/02/2014, 18:20

... stimulate the formation of glucuronate although not that of glucuronate 1-phosphate in microsomes. These data indicate, therefore, that UDP-glucuro- nate hydrolysis to glucuronate 1-phosphate is ... concentrations of glucuro- nate 1-phosphate < 0.5 mm, indicating that the glu- curonate 1-phosphate phosphatase activity was not underestimated because of substrate inhibition. Thes...

Ngày tải lên: 19/02/2014, 07:20

... of light path of the cuvette], which con siders the decrease of the concentration of oxaloacetate in equilibrium with L -malate during t he formation o f NADH (the concentrations of malate and ... strong accumulation of propionyl-CoA in the DmcsA-strain, the activity of methylisocitrate lyase is twice as high than that of the wild-type. The addition of acetate...

Ngày tải lên: 19/02/2014, 16:20

... leftmost word of A the rightmost word of A tgt the translation of A p the translation of A h the leftmost word of the translation of A the rightmost word of the translation of A Table 2: Features adopted ... semantic role of the argument, the head word and the boundary words of the argument. On the target side, the trans- lation of the verbal...

Ngày tải lên: 19/02/2014, 19:20