Báo cáo khoa học: The role of residue Thr249 in modulating t

Báo cáo khoa học: The role of residue Thr249 in modulating the catalytic efﬁciency and substrate speciﬁcity of catechol-2,3-dioxygenase from Pseudomonas stutzeri OX1 ppt

... compilation ª 2006 FEBS The role of residue Thr249 in modulating the catalytic efﬁciency and substrate speciﬁcity of catechol-2,3-dioxygenase from Pseudomonas stutzeri OX1 Loredana Siani 1, *, Ambra ... two residues and the edge of the substrate ring could prevent binding of 3,6-DMC and 3,5-DMC, as shown in Fig. 2- D,E,F. Thus, the bin...

Ngày tải lên : 30/03/2014, 10:20

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Báo cáo khoa học: A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components ppt

... Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunol- ogy 105, 375–390. 5 Caughey G (2001) New developments in the genetics and activation of ... on serglycin. Together, these findings indicate that the reduced amounts of neutral proteases in the absence of serglycin is not caused by missort...

Ngày tải lên : 07/03/2014, 11:20

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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... in obese mice In order to gain insights into the potential biologically relevant role of miR-27 in the regulation of adipose tissue functions in vivo, we examined the expression of miR-27 in ... together, these results illustrate a critical and speciﬁc role of miR-27 in the regulation of adipogenic differentiation. miR-27 prevents the induction of PPA...

Ngày tải lên : 18/02/2014, 08:20

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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

... with glycine alone was performed and no binding was observed. In our hands, as others [54], the most reproducible data was obtained from injections of the metal into a solution of the protein. Typically ... proteins they probably form part of the copper binding sites in this protein. Although there are four histidines in the C-terminal, another histidine is present a...

Ngày tải lên : 19/02/2014, 06:20

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Tài liệu Báo cáo khoa học: A role for the intersubunit disulﬁdes of seminal RNase in the mechanism of its antitumor action docx

... mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing action of the cytosolic RNase inhibitor, a resistance due to the dimeric structure of the enzyme. ... devoid of toxicity as native, dimeric BS-RNase (data not shown). It is noteworthy that in the inactive MCM, MCA and MAE monomers Cys31 and Cys32, the...

Ngày tải lên : 20/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx

... of b-strand 3Õ (i.e. the b-hairpin loop and part of the adjoining b-sheet) and Ôresidues in the loop connecting b-strand and a-helix and contiguous residues on the a-helix and the last part of b-strand ... in which the sequence of the b-strands was maintained but the amino acids from loop 3 had been replaced by multiple Ser and Gly residues. Therefore...

Ngày tải lên : 20/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf

... deviates from the original position. In the struc- tural deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-chain at residue 169 (Table 1 and Fig. ... accessibility of His210. The size of the side-chain at residue 169 and the pK 2 showed a clear linear relationship (Fig. 3B). The pK 2 increased as...

Ngày tải lên : 21/02/2014, 03:20

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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx

... inhibitor of growth protein 3 (ING3) PHD, which is another domain involved in chromatin binding and clearly more divergent (e-value 0.019) from DIDO and the other sequences. As the alignment ... distant from the other bran- ches, which was indeed predicted. The other main group, obtained 97% of the time in 20 740 explored trees, contained the DIDO PHD sequences c...

Ngày tải lên : 07/03/2014, 21:20

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Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx

... pregnenolone, including the effect of the steroid products on the yeast sterol synthesis pathway, acetylation of the product, availability of the substrate, electron ﬂow and localization of the different protein ... steroid-producing cells with respect to the coupling of the SCC and 3b-HSD reactions; the inhibitory effect of steroid products on CYP11A1 subs...

Ngày tải lên : 08/03/2014, 08:20

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Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf

... show the critical role of the last amino acids in the C-terminus of MaL. Deletion of the four last amino acids strongly reduced the expression of the protein in T. reesei and S. cerevisiae. Further- more, ... C-terminal carboxylate group in MaL is hydrogen-bonded to the side chain of His140, which is one of the His residues coordinating the T2 copper i...

Ngày tải lên : 16/03/2014, 00:20

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