Báo cáo khoa học: Specific TSC22 domain transcripts are hypertonically induced and alternatively spliced to protect mouse kidney cells during osmotic stress pptx

... ª 2006 FEBS Specific TSC22 domain transcripts are hypertonically induced and alternatively spliced to protect mouse kidney cells during osmotic stress Diego F. Fiol, Sally K. Mak* and Dietmar ... sequester other TSC22D family members [20]. TSC22D2 and TSC22D4 are regulated by hyperosmolality in kidney cells In mIMCD3 cells exposed to hyperosmol...

Ngày tải lên: 30/03/2014, 10:20

... [8], and are colored green. These two binding sites, Met1 and Phe7 in the N-terminal inhibitory reactive site, and His18 in the secondary CPY-binding site are labeled. (B) The basic (Arg, His, and ... this inhibitor to bind to the anionic phos- pholipids, including PS and phosphoinositides. The relocation of I C leads us to propose a working model in which I C in the cytop...

Ngày tải lên: 19/02/2014, 05:20

... It has been shown to bind strongly to single-stranded RNAs that are A and U rich. Taking into account its ability to rescue a folding trap of a splicing defective intron [14] and its requirement ... between the N-terminal domain of Hfq and the Sm and Sm-like (L-Sm) proteins of eukaryotes and archaea [11,15,16]. These proteins are components of the spliceosome complex an...

Ngày tải lên: 19/02/2014, 12:20

... sequence of the plus-strand 3¢ UTR, and t he 3¢ CATATGCTC f ragment o f the minus- strand are essential to in vitro syn thesis o f t he minus-strand RNA a nd the plus-strand RNA, respectively. ... RNA competitors were –RNA0, –RNAr1 (a 328 nucleotide fragment adjacent to the minus-strand 3¢ UTR), –RNAr2 (a random sequence corresponding to positions 2033–2500 of the minus-strand g eno...

Ngày tải lên: 19/02/2014, 16:20

... intact (lanes 1 and 1¢), ECP-cleaved (lanes 2 and 2¢) and subtilisin-cleaved (lanes 3 and 3¢) G-actin before (lanes 1, 2 and 3) and after heating in the calorimetric cell up to 80 °C (lanes 1¢,2¢ and 3¢). ... phalloidin and P i analogs. These results are discussed with regard to a more open conforma- tion of the interdomain cleft in the cleaved actin com- pared to inta...

Ngày tải lên: 06/03/2014, 22:21

... The band of the b-subunit became very faint. Some new bands between bands 1 and 3 became clear, and sev- eral bands around bands 4 and 5 became stronger. The a-subunit band changed little during ... the b-subunit became very faint. Some new bands between bands 1 and 2 became clearer and several bands around bands 4 and 5 also became darker. The band strength of the b-subunit dec...

Ngày tải lên: 07/03/2014, 21:20

... h (blue squares) were sensitive to H 2 O 2 oxidative stress, whereas cells cultivated in 1.1 mm glucose (green squares) were much more resistant than cells in 111 mm glucose (red squares) or 0 ... production and increases resistance to stresses [25]. A C E G F B D Fig. 7. Oxidative stress and DNA damage observation. (A) Oxidative stress accumulation was observed using H 2 DC...

Ngày tải lên: 14/03/2014, 23:20

... carotenoid composition and preferential binding of spirilloxanthin to the reaction center and anhydro- rhodovibrin to the LH1 antenna complex in Rhodobium marinum. Photochem Photobiol 74, 444–452. 23 ... lowest excitonic state in response to a temperature increase of 50 K was estimated to be 6.4%. Given the amount of spectral shift (66 cm )1 ) and band broadening (57 cm )1 ), it...

Ngày tải lên: 30/03/2014, 02:20

... source data. Our task is to identify and extract both. Since LbR systems must quickly adapt and scale well to new domains, we need to be able to work with large amounts of data and minimal super- vision. ... texts. Our system automatically acquires domain- specific knowledge (classes and actions) from large amounts of unlabeled data, and trains a probabilis- tic model to...

Ngày tải lên: 23/03/2014, 16:20

... similar to ours, i.e., to try to capture changes in ranking of senses for documents from different do- mains. Domain adaptation is also an approach for fo- cussing on domain -specific senses and used ... into two sets, i.e., training and test sets. The training set is used to train SVM classifiers, and the test set is to test SVM classifiers. For each domain, we collected n...

Ngày tải lên: 30/03/2014, 21:20