Báo cáo khoa học: Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide ppt
Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt
... sites are located in the concave face of the protein near regions of invariant Trp and Asn arrays. The major binding site spans ARM repeats 2, 3 and 4 (Fig. 1A) . In the major binding site, the ... Characteristics of the importin -a: CLIC4 NLS peptide interaction. NLS residue Interactions a Van der Waals’ contact area (A ˚ 2 ) b Buried surface area (A ˚ 2 ) RSCC c...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... 13% of the accessible surface area of each dimer. Neighboring tet- ramers came into loose contact with each other in the crystal packing. Similar molecular arrangements have been found in the crystal ... 100°C. Int J Syst Bacteriol 46, 1070–1077. 10 Kawarabayasi Y, Hino Y, Horikawa H, Yamazaki S, Haikawa Y, Jin-no K, Takahashi M, Sekine M, Baba S, Ankai A et al. (1999) C...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc
... consist of two domains, a large a ⁄ b domain and a small a domain with the catalytic site at the interface of the two domains [4,5]. HAPs can initi- ate hydrolysis of phytate at either the C 3 (EC ... than the a domain. For example, the phytase of Aspergillus fumigatus shows closer similarity to PhyK in the a ⁄ b domain than in the a domain...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx
... analysis of DESC1 suggests a possible rigid domain association between the N-terminal SEA domain and the back site of the proteinase domain. This interaction would fix the SEA domain in a loca- tion ... markedly from that of other struc- turally known TTSPs. Based on surface analysis, we propose a rigid domain association for the N-terminal SEA domain with...
Ngày tải lên: 19/02/2014, 00:20
Tài liệu Báo cáo khoa học: Crystal structure of the BcZBP, a zinc-binding protein from Bacillus cereus doc
... concentra- tion justifies the presence of acetate in the crystal structure. The binding of acetate in the active site is a further indication that the enzyme may be involved in deacetylation because acetate ... present the crystal structure of BcZBP at 1.8 A ˚ resolution. The N-terminal part of the 234 amino acid protein adopts a Rossmann fold whereas...
Ngày tải lên: 19/02/2014, 00:20
Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
... residues marked ÔdÕ), with most residues at the interface coming from the PYR and PP domains. This is in agreement with the average mobility of the domains in the crystal; the PYR domain has the lowest ... in blue, the middle domain in green and the PP domain in red. The secondary structure elements are labelled as defined in Fig. 4. The cofacto...
Ngày tải lên: 20/02/2014, 11:20
Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
... l-glutamine, with that of Erwinia carotovora asparaginase, which has substrates other than l-glutamine, shows that Mglu has a larger substrate-binding pocket that prevents the binding of l-asparagine ... the structure of E. carotovora asparaginase in complex with l-glutamate (PDB 2hln) [18]. Mglu binds l-glutamate in an extended form (Fig. 7A) with a contact area...
Ngày tải lên: 06/03/2014, 09:22
Báo cáo khoa học: Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases pptx
... of the interactions of papain with loop L6 of chagasin and loop L2 of cysta- tin B. (C) Zoom -in view of the interactions of papain with loop L4 of chagasin and the N-terminal segment of cystatin ... Od1 atom of N64e forms a water-mediated contact with the main-chain N atom of G68, and the main-chain nitrogen of G66 of chagasin forms a water-mediat...
Ngày tải lên: 16/03/2014, 04:20
Báo cáo khoa học: Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima docx
... containing the act- ive site. The lower domain is reminiscent of the AMP- binding domain of eukaryotic FBPases (supplementary Fig. S2). The active site is located at the bulge of the C-terminal ... site. The second domain has a three-layer motif with two layers of a- helices flanking the second b-sheet. This domain corresponds to the FBP-binding do...
Ngày tải lên: 16/03/2014, 11:20
Báo cáo khóa học: Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex doc
... by a core DNA polymerase assembly that is attached to a sliding clamp. Although a single sliding clamp may remain attached to the polymerase during replication of the leading strand, each Okazaki ... nuclear antigen (PCNA) in eukaryotes and archaebacteria] that tether the DNA polymerase to DNA [2]. The interaction between the DNA polymerase and the sliding clamp enables...
Ngày tải lên: 16/03/2014, 16:20