Báo cáo khoa học: Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism pptx
Báo cáo khoa học: Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism pptx
... desensitization of the pancreatic beta cells to the actions of these drugs. Experiments investigating the effects of chronic exposure of pancre- atic islets and beta cell lines to sulfonylureas ... 2006) doi:10.1111/j.1742-4658.2006.05513.x Prolonged exposure of pancreatic beta cells to the sulfonylureas glibenca- mide and tolbutamide induces subsequent des...
Ngày tải lên: 30/03/2014, 10:20
Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
... between the varying affinities and the nonvarying response of these agonists could be explained by the number of receptors to be occupied by these agonists to get activation of the second messenger ... canonical backbone conformers observed for a-amino acids. Therefore the addition of a backbone methylene group could have minor effects on the overall conformation and bi...
Ngày tải lên: 08/03/2014, 08:20
Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf
... bc 1 sub-complex, but the presence of only one of these two subunits does not substitute for the other. After the addition of ISP, the binding of the last subunit (i.e. Qcr10p) finally occurs. These find- ings ... too small to explain the dimerization of the bc 1 complex at this stage (i.e. just after the addition of ISP and Qcr10p). On the other hand, in the t...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt
... analysed using the selecton tool [38] at http://selecton.tau.ac.il/. The ratio between nonsynonymous (Ka) and synony- mous (Ks) substitutions was calculated for every codon using the default M8 codon-substitution ... (d) sequences contain between four and seven conserved sequence regions (CSRs) covering mainly the b-strands of the catalytic TIM barrel [3,11–13]. Of the three G...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt
... salt concentrations (Table 1, Fig. 5). In the comparison of the presence of NaCl and of CaCl 2 , the ionic strength was more important for inactivation or precipitation than the individual ions. ... at the two ends of the molecule (Fig. 3). An assignment of these relaxed structures to sequence regions of PLDa2 has not yet been possible. According to the volume estima...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... analysis. Opposite effects of hypoxia on expression of HO-1 and HO-2 mRNA in YN-1 cells To explore the mechanism of the hypoxia-mediated reduction of HO-1 and HO-2 protein levels, we ana- lyzed the effects of ... promoter function of the human HO-2 Fig. 7. Characterization of the human heme oxygenase (HO)-2 gene promoter. (A) Identification of the transcriptio...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... His145Asn mutations on the affinity of metal binding to arginase II To further examine the effects of the His120fiAsn and His145fiAsn mutations on the interaction of the enzyme with manganese ions, maximally ... molecule, by lowering the pK a for proton ionization and generation of the hydroxide that nucleophilically attacks the guanidino carbon of the scissile...
Ngày tải lên: 20/02/2014, 02:21
Báo cáo khoa học: Investigations into the ability of an oblique a-helical template to provide the basis for design of an antimicrobial anionic amphiphilic peptide pot
... methodology of Simpson [58]. The interaction parameter (a) relates the interaction of each molar fraction of components within a monolayer with the free energy of mixing. Values of a were computed (Table ... facili- tates their interaction with the anionic membranes of microbial cells, and they exert their antimicrobial action by the use of nonreceptor-based mechanisms...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: Flexible nets The roles of intrinsic disorder in protein interaction networks potx
... association-induced local water removal increases this hydrogen-bond stability [141]. Important for the present work, the application of the dehydron concept in an analysis of the evolution of the ... survival. These observations are consistent with Fisher’s classic proposal that pleiotropy con- strains evolution [24,25]. Other important considera- tions include the timing a...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: MicroRNAs and the regulation of fibrosis potx
... fibrosis Cardiac fibroblasts are the most numerous cell type in the heart and are central to the regulation of cardiac ECM metabolism [16]. Excess deposition of ECM components in the heart is associated ... hypertension, myo- cardial infarction and cardiomyopathy, and there is now accumulating evidence that implicates miRNAs in the modulation of these conditions [17–21]. Th...
Ngày tải lên: 15/03/2014, 11:20