Báo cáo khoa học: Site-specific casein kinase 1e-dependent phosphorylation of Dishevelled modulates b-catenin signaling ppt

... determination of FAK and PI3 -kinase activation in response to Alt-C-induced chemotaxis, we analyzed the effect of PI3 -kinase inhibitor on FAK phosphorylation and FAK-associated PI3 -kinase upon stimulation ... PI3 -kinase inhibition is accompanied by an increase of Erk-2 nuclear translocation suggesting a modulatory role of PI3 -kinase signaling pathway on Erk-2 activity. S...

Ngày tải lên: 07/03/2014, 21:20

... Min 1 1 Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul, Korea; 2 Medical Research Center for Cancer Molecular Therapy and Department of Biochemistry, College of Medicine, ... Moreover, EGCG induced tyrosine phosphorylation of PLC-c1 which was inhibited by pretreatment of anti- oxidant (data not shown). The effects of EGCG on the activa...

Ngày tải lên: 16/03/2014, 16:20

... the initiation of neoplasmic transformation. Regulation of DAPK function The attenuation of DAPK function in a number of cancers has mainly been attributed to hypermethylation of the DAPK promoter ... include increasing methylation of DNA, deacetylation of core histone proteins and RNA interference. Methylation of CpG islands in the promoter regions of genes, by addi- tion...

Ngày tải lên: 29/03/2014, 08:20

... code [5–7]. As a consequence of the lack of direct genetic control of their biosynthesis, natural PTMs vary in site and level of incorporation, leading to mixtures of modified pro- teins that may ... clear demonstrations of the utility of linear ligation assembly, a convergent chemo- selective approach can offer the key advantages of more ready and flexible modification of a we...

Ngày tải lên: 18/02/2014, 17:20

... University of Valladolid School of Medicine, Spain The phospholipase A 2 (PLA 2 ) superfamily is a hetero- geneous group of enzymes with distinct roles in cell function [1–5]. The common feature of these ... multiple functions of various kinds (i.e. homeostatic, catabolic and signaling) in different cells and tissues [3,7]. Several lines of evidence have suggested a key role for...

Ngày tải lên: 18/02/2014, 17:20

... loss of most of the deuterium (retention, 7–8%), and, as expected, biosynthesis of these divinyl ethers from the corresponding 14(S)-deuterated hydroper- oxide was accompanied by retention of deuterium ... synthase [22] and prostacyclin synthase [22]. In the case of divi- nyl ether biosynthesis, the initial step is believed to consist of cleavage of the O-O bond of the hydrope...

Ngày tải lên: 16/03/2014, 18:20

... Department of E.T.S.I. of Telecommunication University of Madrid mcrg52@tid.es ,lahg23@tid.es Abstract The natural language spoken dialogue system AGORA (TID's advanced system of services ... platform of association, composed by a Kernel and an increasing amount of modules or subdialogues. Another important advantage of AGORA is its infrastructure that facilitates the fas...

Ngày tải lên: 24/03/2014, 03:20

... and a protein con- centration of 21 lm. The spectra were acquired with a scan rate of 50 nmÆmin )1 , a response time of 1 s, a step of 0.2 nm, and a band width of 1 nm, and were averaged over 10 ... period of time. For comparison, rsCD1b was also analyzed. Irrespective of the pH, in terms of resonance units, the interaction of rsCD1e2 ) with liposomes was con- siderably high...

Ngày tải lên: 28/03/2014, 22:21

... FEBS AC–G-protein complex terminates signaling, possibly also with the involvement of secondary modifications such as phosphorylation [10,11]. Termination of acti- vation of bacterial class III ACs has ... plot (Lineweaver–Burk) of substrate kinetics of Rv1625c in the presence of three concentrations of poly-P75 as an inhibitor. Y. L. Guo et al. Polyphosphate inhibition of a...

Ngày tải lên: 30/03/2014, 02:20

... autophosphorylation activity, loss -of- function (kinase- inactive) forms of the MAPKs were produced as GST-lofMPK3 and GST- lofMPK6. However, when lofMPK3 and lofMPK6 proteins were tested for phosphorylation ... OXI1, no phosphorylation of lofMPK3 or lofMPK6 was observed (Fig. 5A). On the other hand, when OXI1 K45R or PTI1-4 proteins were mixed with active MPK3 or MPK6 kinases, phos...

Ngày tải lên: 14/02/2014, 19:20