Báo cáo khoa học: Molecular basis of cerebral neurodegeneration in prion diseases pdf

... cellular isoform of the prion protein is a key medi- ator in prion pathology. Transgenic models were instrumental in dissecting propagation of prions, disease-associated isoforms of prion protein and amyloid ... isoform of prion protein is not exactly known, the impact of gain of toxic function or loss of function, or a combination of both, in prion pathology i...

Ngày tải lên: 30/03/2014, 09:20

... accompanied by improved bind- ing to longer ligands (up to five atoms in the main chain) and retained binding to shorter ligands [55]. Of the 21 changes in the evolution of R7 from native GLYAT ... some of the key findings that have led to our current under- standing of the molecular mode of action of glypho- sate and the molecular basis for glyphosate resistance. Structur...

Ngày tải lên: 14/02/2014, 14:20

... 2737 Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the ... a result of the synthesis of an excess amount of TNSALP (Fig. 1C, lanes 4–6, see the top of gel). In the present experiment, TNSALPs were expressed Molecular basis of pe...

Ngày tải lên: 07/03/2014, 05:20

... activa- tion of the toxin in the gastrointestinal tract compro- mises the intestinal barrier of intoxicated animals, allowing the dissemination of toxin via the bloodstream to the main target organs of ... that toxin-induced oedema of the brain is due to the damaging action of the toxin on vascular endothelial cells [45]. Toxin- induced increase in vascular permeability in t...

Ngày tải lên: 14/03/2014, 22:20

... the main binding determinants of the IL-4 ⁄ IL-4Ra ligand–receptor interaction, contrib- uting more than 80% of the overall binding free energy. (A) The side chain guanidinium group of Arg88 of ... can possibly be explained by the homodimeric nature resulting in four binding interfaces for a single Noggin molecule. W. Sebald et al. Molecular basis of cytokine signalling FEBS J...

Ngày tải lên: 15/03/2014, 09:20

... with GDP (red) obtained using MOE software. (B) Close up of the purine ring binding site in the C-terminal domain. Lines indicate hydrogen bonds interactions. Let- tering in red corresponds to ... carbon 2 of the guanine ring may interact with the side chain of Glu309, whereas the carbonyl group at position 6 of the guanine ring may interact with the hydroxyl group of the Tyr239...

Ngày tải lên: 16/03/2014, 01:20

... Linguistics Improving Classification of Medical Assertions in Clinical Notes Youngjun Kim Ellen Riloff Stéphane M. Meystre School of Computing School of Computing Department of Biomedical Informatics ... recall gains on the minority classes. 1 Introduction Since the beginning of the new millennium, there has been a growing need in the medical community for Natural...

Ngày tải lên: 20/02/2014, 05:20

... theoretical interest of this distribution arises from the possibility of using it as a basis for an operational definition of words in printed texts. If texts are considered purely as sequences of ... not shared by the others, of being concentrated at relatively low values of length, and of having no elements exceeding a certain length (Fig. 1). Words, defined in th...

Ngày tải lên: 16/03/2014, 19:20

... predicting listener backchannels. Au- tonomous Agents and Multi-Agent Systems, 20:70– 84, Springer. Gabriel Murray and Steve Renals. 2008. Detecting Action Meetings in Meetings. In Proceedings of the ... MUMIN Coding Scheme for the Annotation of Feedback, Turn Management and Sequencing. Mul- timodal Corpora for Modelling Human Multimodal Behaviour. Special Issue of the International...

Ngày tải lên: 23/03/2014, 16:20

... enzyme- bound, adenine-lacking cobalamins for free adenosyl- cobalamin, an adenine-containing cobalamin through intermediary formation of apoenzyme. The function of reactivating factors is to ... considered models of the damaged cofactor (adenine-lacking cobalamin) and intact coenzyme (adenine-containing cobalamin), respectively. As shown in Fig. 3A, when the diol dehydratase–CN-Cbl c...

Ngày tải lên: 16/03/2014, 05:20