Báo cáo khoa học: TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain pdf

... regulation of CREB is also important. The activation and repression are mediated by the basic leucine zipper domain of CREB. In this review, we focus on the basic leucine zipper domain in the regulation ... MINIREVIEW TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain Hiroshi Takemori 1 , Junko Kajimura 1 and Mitsu...

Ngày tải lên: 30/03/2014, 08:20

... (Table 1). These results fit with the hypothesis that the rate of fX activation is regulated by formation of the fVIIIa–fX complex which, in fact, is the true substrate in the fX activation. Other explanations ... the dissociation rate. The average ratios of these constants give the K d value of 118 ± 33 nm in the absence and 32 ± 14 nm in the presence of fVIII and agree wi...

Ngày tải lên: 23/03/2014, 11:20

... active site subdomains, we man- aged to model the entire domain without it. Another significant finding concerns the nature of the acid residues within the active site of Rep245. The carboxylate ... polymerase activity on metal ions. The results are the means of three independent experiments. (C) The dependence of polymerase activity on the temperature was determined by...

Ngày tải lên: 18/02/2014, 18:20

... [6]. The LPS-binding activity of LF may account for the other properties of this pro- tein in the modulation of the inflammatory process [3]. The stimulation of mammalian cells by LPS occurs through ... LPS monomer is then transferred to CD14. CD14 is required for the efficient transfer of the LPS monomer to MD-2, which is either soluble form or associated with the ecto- do...

Ngày tải lên: 06/03/2014, 11:20

... between the PI3K ⁄ Akt path- way and HO-1 regulation in PC12 cells [29,30]. This may be through nuclear factor E2-related factor-2 (Nrf2), a member of the cap’n’collar family of basic leucine ... of HO-1 induction by insulin through the PI3K ⁄ Akt cascade and the Nrf2 transcription factor in both transformed renal cells and primary mouse renal tubular epithelial cells. Insul...

Ngày tải lên: 07/03/2014, 12:20

... thioesterase activity and it is associated with the inner mitochondrial membrane [10–13]. In the steroidogenic cells, the step that determines the rate of steroid synthesis (the rate-limiting step) is the ... the presence of CHX, the fatty acid bypasses the absence of ACS4 but not the absence of StAR. Then, the partial inhibition pro- duced by CHX on AA stimulated stero...

Ngày tải lên: 16/03/2014, 12:20

... of recombinant PACSIN 1. (A) Domain struc- ture of PACSIN 1 with an N-terminal F-BAR domain and a C-terminal SH3 domain. The F-BAR domain was formerly known as the CDC15-NT domain, and includes a con- served ... represent the molecular masses of the corresponding marker proteins. The Y-axes show the relative fluor- escence intensities at 280 nm, with the left axis corresp...

Ngày tải lên: 23/03/2014, 09:21

... the cytoplasmic membrane ⁄ organelle and insoluble frac- tions, whereas the full-length ATN1 and the other C-terminal fragment were individually localized in the other fractions. Therefore, the ... COS- 7 cells as the size of the polyQ was increased. Next, we assessed whether the quantitative increase of the full-length ATN1 and fragments was the result of an accumulation...

Ngày tải lên: 15/02/2014, 01:20

... with the surface of the cell that pro- duced them. The ECM can be found in different forms, from the hard compositions of bone to the soft structures of connective tissue. Collagens are the main components ... interaction between a cystein residue in the prodomain and Zn 2+ in the active site of the catalytic domain. Two major types of endogenous inhibitors regulate the...

Ngày tải lên: 18/02/2014, 11:20

... speculate that the Pi release is promoted by opening of the ‘back door’ [38], while ADP becomes less accessible through the closing of the ‘main door’ on the top of the protomer or by some other mechanism. ... incubation with cofilin at pH 8.0 the rate and the extent of actin cleavage was the same in the presence and absence of 30 mm Pi. On the other hand, at pH 6.5 th...

Ngày tải lên: 19/02/2014, 07:20