Báo cáo khoa học: Inhibitor-mediated stabilization of the conformational structure of a histone deacetylase-like amidohydrolase pptx

... studies and the analysis of ligand-binding data. Each of the available techniques has limitations that restrict interpretation of the data. However, taken together, they provide a coherent body of ... donor and acceptor (X-axis). The distance is expressed as the ratio of the distance ‘r’ separating the donor and the acceptor over the distance resulting in 50% of...

Ngày tải lên: 16/03/2014, 22:20

... what the speaker uttered, they are part of what the hearer gathers from an utterance. Speaker and Hearer are indexical con- stants to be replaced by the speaker(s) and the hearer(s) of the ... episodes and the utterances them- selves) in a way that echoes the hierarchy of temporal and modal operators of the sentences and clauses from which the tokens arose....

Ngày tải lên: 17/03/2014, 08:20

... salt) was added to a final concentration of 100 m M , while in the other sample KCl was added to the same concentration. The pH was adjusted to 6.9 in both samples and an antibiotic cocktail was ... tempera- ture dependence and tend to maintain their positive or negative correlations. Relaxation data and dynamic parameters Relaxation parameters were measured at 30 °C for 42 of the...

Ngày tải lên: 07/03/2014, 21:20

... Uni- versity, and were carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. All efforts were made to minimize the number of animals used and their ... in cardiomyocytes will provide a molecular basis for new therapeutic strate- gies targeting specific pathways to treat human heart disease. Materials and methods Animals...

Ngày tải lên: 16/02/2014, 09:20

... 5230–5240. 19 Takeda S, Yamashita A, Maeda K & Maeda Y (2003) Structure of the core domain of human cardiac troponin in the Ca 2+ -saturated form. Nature 424, 35–41. 20 Vinogradova MV, Stone DB, Malanina ... regulation by molluskan troponin, we com- pared the functional properties of the recombinant fragments of Akazara scallop TnI and rabbit fast skeletal TnI. The C-...

Ngày tải lên: 20/02/2014, 01:20

... four types of features using the event of “Abdul Halim Khaddam resigns as Vice President of Syria” and the sentence The resignation of Khaddam was abrupt” as an example. In particular, the “depth” features ... and VP. Also, if a head word is part of an entity mention, then the “canonical” version of that mention is associated with the word, where canonical essentially...

Ngày tải lên: 20/02/2014, 09:20

... Dimer asymmetry and the catalytic cycle of alkaline phosphatase from Escherichia coli Stjepan Orhanovic ´ and Maja Pavela-Vranc ˇ ic ˇ Department of Chemistry, Faculty of Natural Sciences, Mathematics ... catalytic cycle for APase from E. coli A model describing the catalytic mechanism of APase from E. coli, based on the results of the kinetic experiments and in accordance...

Ngày tải lên: 21/02/2014, 00:20

... Ohashi M, Miwako I, Nakamura K, Yamamoto A, Murata M, Ohnishi S & Nagayama K (1999) An arrested late endosome-lysosome intermediate aggregate observed in a Chinese hamster ovary cell mutant ... FEBS Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate Sandra E. Geden 1 , Richard A. Gardner 2 , M. Serena Fabbrini 3 , Masato...

Ngày tải lên: 07/03/2014, 05:20

... (2000) A major conformational change in p97 AAA ATPase upon ATP binding. Mol Cell 6, 1485–1490. 8 Dougan DA, Reid BG, Horwich AL & Bukau B (2002) ClpS, a substrate modulator of the ClpAP machine. Mol ... which leads into a parallel b-sheet. In contrast, the last 12 amino acids of GFP form a b-strand leading into an anti-parallel b-sheet [31]. In the case of GFP–ssrA,...

Ngày tải lên: 07/03/2014, 05:20

... nominative, then the relative pronoun may be taken to be the subject of the clause. This ap- plies to about half of all the instances where the function of the relative pronoun is ambiguous. ... two- thirds of all instances. If was is translated as "what," the das is left untranslated. Alterna- tively the das can be translated by "that" and...

Ngày tải lên: 07/03/2014, 18:20