Báo cáo khoa học: Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential doc

... control substance in this context, because it is an inhibitor of P-glycoprotein rather than MPTP, and is devoid of calcineurin-inhibiting properties [23]. We hypothesized that an increase in steady-state DW m underlies ... 3003–3012 ª 2007 The Authors Journal compilation ª 2007 FEBS Cyclosporin A-induced oxidative stress is not the consequence of an in...

Ngày tải lên: 30/03/2014, 08:20

... of the questions within an analysis of the hypothesis in the con- text of a characterization of the "how" of the entire behavior. By adapting HOPE for processing French, we furthermore ... often are not translated into meaning preserving sentences in English. An example sentence demonstrating this is: Ce singe aime le cafe. (This monkey likes c...

Ngày tải lên: 21/02/2014, 20:20

... performed in order to get an overview of the many compounds of the pancreatic islet extract (Fig. 1a). The prominent signals in the spectrum originated from products of proinsulin. Two insulin variants are ... 60–80% of the islets and as insulin makes up almost 20% of the proteins in the b-cells, proinsulin-derived peptides can be expected to constitute quantit...

Ngày tải lên: 17/03/2014, 10:20

... analysis revealed that with an LCT diet and no fasting, the expression of AOX was significantly higher in VLCAD KO mice than in WT mice. Fasting induced a significant increase in both genotypes; ... [1]. The pathophysiology behind the hepatic damage is not well understood. Oxidative stress has often been discussed, but has never been proven. To gain insights into the...

Ngày tải lên: 15/03/2014, 23:20

... placed at the centre of the cross-linker at a distance of 13.5 cm (minus the height of the culture dish) from the UV lamp. The apparatus calculates the duration of exposure as a function of the desired ... cannot be ruled out. However, as we did not detect any overproliferation or increase in thickness in this model, we suggest that the slight increase i...

Ngày tải lên: 07/03/2014, 11:20

... [103]. Crohn’s disease is an in ammatory disease of the small intestine and ⁄ or the colon. As mentioned already, in the small intestine, the pathogenesis is asso- ciated with a reduced expression of the ... peptide and of other unusual iso- forms of the peptide. The current thinking is that, at least partially, the chronic in ammation results from the in...

Ngày tải lên: 18/02/2014, 06:20

... mixture of 95% methanol and 0.1% trifluoroacetic acid in H 2 O. The retention times of adenosine and adenine, inosine and hyp- oxantine, guanosine and guanine, uridine and uracil, cyti- dine and cytosine ... cytosine were 12.2 and 6.2 min, 10.5 and 4.7 min, 15.2 and 6.1 min, 6.8 and 4.2 min and 6.6 and 3.9 min respectively. The amount of purine or pyrimidine base formed is determ...

Ngày tải lên: 18/02/2014, 17:20

... part of the intestine (Fig. 5M,Q,R). This last finding should be of interest because in terms of func- tion, the fish intestine is highly regionalized both in the larva and in the adult [38]. The ... independent duplications; the first round resulting in the ancestral long repeat unit and the second giving the repeats found in the zebrafish PrP1 sequence. Ana...

Ngày tải lên: 19/02/2014, 16:20

... that they are in control of the system and not the system in control of them. Equally, nothing can be more damaging to satisfactory system opemtion, regardless of how well all other aspects of ... about the data stored in the machine. An understanding of onto/into mappings, one-to-one/one-to-many/many-to-many relationships, set theory, boolean algebra, or pred...

Ngày tải lên: 21/02/2014, 20:20

... if the workflow is robust (i.e. makes use of retry and parallelisation) and the error is confined to a WS (i.e. it does not affect the rest of the workflow). An instance of Biocatalogue and one of ... to get familiar with the characteristic bilingual terminology and other aspects of the domain. Another obvious potential use of this data would be to use it to tra...

Ngày tải lên: 22/02/2014, 03:20