Báo cáo khoa học: Regulation of the muscle-specific AMP-activated protein kinase a2b2c3 complexes by AMP and implications of the mutations in the c3-subunit for the AMP dependence of the enzyme docx

... complexes by AMP and implications of the mutations in the c3-subunit for the AMP dependence of the enzyme Kerstin Lindgren*, Mattias Ormestad*, Ma ˚ rten Persson, Sofia Martinsson, L. Thomas Svensson and ... important for metabolic sensing in all eukaryotes. The muscle- specific isoform of the regulatory c -subunit of the kinase, AMP- activ...

Ngày tải lên: 30/03/2014, 08:20

... is under the direct control of kinases and phosphatases, and the indirect control of phosphorylation through the regula- tion of other apoptotic proteins. Furthermore, many kinases and phosphatases ... phosphorylated protein, the degree of activation and the in uence of other proteins. Phosphorylation signaling pathways are intri- cately interrelated; it was prev...

Ngày tải lên: 14/02/2014, 22:20

... factors, the members of the HSF family are modular proteins composed of functional domains (see figure 2 in [4]). The most con- served domain is the amino-terminal helix-turn-helix DNA-binding domain ... disturbing the protein homeostasis. As a defence mechanism, HSFs induce the synthesis of HSPs that act as molecular chaperones through binding to the hydrophobic surfac...

Ngày tải lên: 18/02/2014, 04:20

... between the dCTP(dUTP)-binding conformer and the dTTP-binding conformer of dCTP deaminase. We were not able to identify structural changes in the main chain of the subunit, or in the interaction of ... both inactive and unfortunately no suitable crystals for the structural analysis of V122G could be obtained. However, the conformation of the main chain in...

Ngày tải lên: 18/02/2014, 16:20

... properties, and i t interacts with several protein partners such as myosin, a ctin, M protein, C protein, MURF-1, calpain 3, myomesin, a-actinin, nebulin, telethonin and obscu rin. The elastic domains ... experimentally using the Bradford method [44] to measure the protein concentration of the T800-containing solution, using HMM for the standard curve. MS Proteins wer...

Ngày tải lên: 19/02/2014, 16:20

... spermidine and spermine) through conversion of l-arginine into l-ornithine [16]. The lat- ter is in turn used by ODC to produce putrescine, the precursor of spermidine and spermine. To further ... are not induced in response to virus infection As the two isoforms of arginase, I (hepatic isoform) and II (extrahepatic isoform), may contribute to the arginase activity m...

Ngày tải lên: 07/03/2014, 21:20

... with the site of ATP binding and may exploit common side chain interactions; or (b) the conforma- tions of residues involved in RNA binding may be directly or indirectly coupled to the binding of ... shown in the crystal structure of rat MVK bound to ATP [17], depicted in Fig. 9A, the active site of the enzyme is located at the interface of the N- and C...

Ngày tải lên: 16/03/2014, 06:20

... condi- tions, by the Jun N-terminal kinase, the P38c MAP kinase, the cyclin-dependent kinases 1 and 2 and the PDZ-binding kinase, resulting in changes in distribu- tion and stability of the protein [20–23]. ... translational efficiency by acting as binding sites for some regulatory proteins or by inhibiting the bind- ing or scanning of the translational...

Ngày tải lên: 22/03/2014, 16:20

... upon germination (Fig. 1B). The rate of hypocotyl growth is greatest in the evening and minimal in the morning, and can be entrained by light even before the cotyledons emerge from the seed coat ... expression of mRNA in these pathways is always matched by circadian regulation at the level of protein synthesis. However, in some cases protein lev- els ar...

Ngày tải lên: 23/03/2014, 10:20

... Eklund EA & Kakar R (1999) Recruitment of CREB- binding protein by PU.1, IFN-regulatory factor-1, and the IFN consensus sequence-binding protein is necessary for IFN-c-induced p67phox and gp91phox ... IRF-1 is a candidate for the mediator of IFN-c action. In contrast, no effect was observed on the expression of IRF-2 protein. To determine whether IRF-1 and...

Ngày tải lên: 23/03/2014, 13:20