Báo cáo khoa học: Expression and functional characterization of P2Y1 and P2Y12 nucleotide receptors in long-term serum-deprived glioma C6 cells ppt

... Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1 ⁄ ERK2 and phos- phatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells. Br J Pharmacol ... characterized the expression and functional properties of the ADP- sensitive P2Y 1 and P2Y 12 nucleotide receptors in glioma C6 cells...

Ngày tải lên: 30/03/2014, 08:20

... on Research and development in information retrieval, pages 411–418, Singapore. ACM. Wayne Xin Zhao, Jing Jiang, Hongfei Yan, and Xiaom- ing Li. 2010. Jointly modeling aspects and opin- ions with ... 2008. Opinion mining and sentiment analysis. Foundations and Trends in Infor- mation Retrieval, 2(1-2):1–135. Ana-Maria Popescu and Oren Etzioni. 2005. Extracting product features...

Ngày tải lên: 19/02/2014, 19:20

... antigenic determinants and the functional domains of TC have not been identified. Cloning [5–7] and recent expression of several kind- red Cbl-binding proteins [8–11] helped to elucidate some of their ... EV, McLoughlin P & Morgan AC (1996) Synthesis of coba- lamin–biotin conjugates that vary in the position of cobalamin coupling. Evaluation of cobalamin derivative bi...

Ngày tải lên: 20/02/2014, 01:20

... data describing the catalytic cycle of two mammalianperoxidases,LPOandMPO,inorderto reconcile the apparent inconsistencies and to provide some new insights. MPO and LPO share functional and structural ... existence of two Cpd I isomers both in MPO and LPO. In the case of MPO the evidence is: (a) the EPR spectrum of a trapped amino acid radical found by Lardinois et al. [...

Ngày tải lên: 20/02/2014, 02:21

... [22] and increased extracellular Cu causes an increased turnover of PrP c [23]. Binding of Cu to the protein in uences its ability to interact with other proteins such as plasminogen [24] and glycosaminoglycans ... activity. We determined that the active site consists of two domains. The first includes the Cu-binding domain and the second includes the conserved hydrophobic domain...

Ngày tải lên: 21/02/2014, 00:20

... probes and optical spectroscopy are now entering a phase enabling the in vivo interrogation of the role of oligomers in amyloidosis. Such techniques used in parallel with in vitro experiments, of increasing ... efficiency changes upon protein binding. Recently, new antibody stains have allowed precise moni- toring of the oligomer size and distributions using multicolor labe...

Ngày tải lên: 06/03/2014, 09:22

... restrictions in Hebrew on the co-occurrence of several determiners in the same NP and on their relative order- ing within the NP. To explain them, Glin- ert (Glinert, 1989) adopts a functional ... following open problems in the resulting sample: the selection of the unmarked realization option and the deter- mination of the default value of the definite feature rema...

Ngày tải lên: 08/03/2014, 06:20

... and kinetic constants related to the binding of l-Arg [10–14] and NOHA [10], nothing is known about the thermodynamics and kinetics of the binding of guanidines and N-hydroxy- guanidines to iNOS. ... modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron–N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in dete...

Ngày tải lên: 16/03/2014, 22:20

... are being measured within the intact network operating in its cellular environment (i.e. either in the intact cell or at least in a cell lysate) and adopting a sufficiently large spectrum of differ- ent ... take into account only the in uence of substrates and products on the reaction rate. The rate of meta- bolic enzymes determined by network perturbations of intact cells...

Ngày tải lên: 23/03/2014, 06:20

... earlier in this paper. The results are obtained using the two-stage training schedule, including six iterations for training phrase translation models and two iterations for training lexicon ... the baseline and also over training phrase or lexicon models alone. The two- stage training of both models gives the best result of 27.33%, outperforming the baseline by 1.1 BLEU point...

Ngày tải lên: 23/03/2014, 14:20