Báo cáo khoa học: Stage-specific activation of MIG-17⁄ADAMTS controls cell migration in Caenorhabditis elegans docx

... and of five in the Caenorhabditis elegans genome. ADAMTS members contain a signal peptide, a prodomain, a metalloprotease (MP) domain, a disintegrin (DI) domain, a variable number of thrombospondin ... results indicate that activation of MIG-17 occurred in the basement membranes of the muscle, intestine and gonad in the L3 larvae. We next studied the activation of MIG-1...

Ngày tải lên: 30/03/2014, 04:20

... B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Gut 42, 779–787. 23 Lakshminarayanan ... 4347 indicating that LPS induces ICAM-1 expression in SCs, suggest that ICAM-1 may play a role in the focal accumulation and antigen-induced activation of T cells in inflammat...

Ngày tải lên: 18/02/2014, 18:20

... domain, the site of ATP binding, exhibits sequence homology with the catalytic domains of tyro- sine kinases [30]; (b) staurosporine binds to the same ATP site as that of various protein kinases, ... binding results in 3D terms, the ARM domain model [30] was analyzed. The original 3D model of the ARM domain was built using crystal structures of insulin receptor kinase and hematopo...

Ngày tải lên: 06/03/2014, 11:20

... the changes in the thermal unfolding of actin induced by interaction of G-actin with actin-binding proteins [25– 27], G–F transformation of actin, and stabilization of F-actin by phalloidin and P i analogs ... conformational transitions in actin crystals involve so-called DNase I-binding loop (D-loop) in subdomain 2 of the actin molecule [7]. In tetramethylrhodamine-modified...

Ngày tải lên: 06/03/2014, 22:21

... was capable of digesting factor VIII molecule [7], suggesting a pathological role of this antibody in vivo. The Bence-Jones proteins, which are found in the urine of patients with certain diseases, particularly ... The light chain of ECL2B mAb was capable of cleaving a pep- tide (RSSHFPYSQYQFWKNFQTLK) derived from CCR5, a chemokine receptor, which plays a crucial role in HIV i...

Ngày tải lên: 07/03/2014, 21:20

... roles of CaM in intracellu- lar signaling, there is significant interest in better understanding the structural basis of its recognition of target proteins. CaM is a 148-amino-acid protein consisting ... environment of the cell, the network of CaM-dependent signaling pathways may play a role in the cellular regulation of protein processing. Excess production of iNOS in t...

Ngày tải lên: 16/03/2014, 13:20

... the C-terminus also increased VEGFR-1 binding and migration of THP-1 monocytes indicating that both the C-terminal residues and O-linked sugars contribute to blocking viral VEGF binding to VEGFR-1. The ... in bioassays that detect receptor binding and cross-linking at the cell surface. These assays made use of BaF3 cell lines expressing chimeric receptors consisting of the extra...

Ngày tải lên: 23/03/2014, 07:20

... special type of ubiquitin-binding domain also found in NEMO. The relation ⁄ relevance of A20 interaction with ABIN proteins regarding the inhibitory effect of the ubiquin editing complex of A20, Itch, ... modified with K63-linked multiubiquitin chains, mediating the recruitment of various ubiquitin-binding proteins involved in TNF signaling, but also with K48-linked ubiquitin cha...

Ngày tải lên: 28/03/2014, 23:20

... state of E278 [22], of individual heme propionates [23,24] and of Y280 [25] was previously studied employing this tech- nique in combination with site-directed mutants and isotopic labeling. Here ... mutants of E78 II in the Paracoccus cyto- chrome c oxidase are characterized in terms of cata- lytic and proton pumping activity, kinetics of heme a 3 reduction and electrochemi...

Ngày tải lên: 30/03/2014, 15:20

... and of differing syntactic annotation of similar infor- mation, which lead to problems mapping between our GR output and the current DepBank. Finally, differences in the linguistic intuitions of ... nodes representing lemma- affix-tags and arcs representing named grammati- cal relations. The encoding of this mapping within the grammar is similar to that of F-structure map- ping in...

Ngày tải lên: 20/02/2014, 12:20