Báo cáo khoa học: Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans docx

... MINIREVIEW Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans Keith P. Choe and Kevin StrangeDepartments of Anesthesiology, ... of damaged proteins and activation of gpdh-1expression. Green arrows and red lines indi-cate activation and inhibition, respectively. Osmosensing and signaling in C. elegans K. P. Choe and K. Strange5786 ... osmotically unstable and the animalundoubtedly experiences periods of desiccation and rehydration in its native habitat. In the laboratory, Osmosensing and signaling in C. elegans K. P. Choe and K. Strange5784...

Tài liệu Báo cáo khoa học: "Cross-Domain Co-Extraction of Sentiment and Topic Lexicons" pdf

... including new topic candi-dates and words in the lexicon C, and the other set of nodes represents sentiment words, including newsentiment candidates and words in the lexicon B.For a pair of ... study the effect of different parameter settings. There areseveral parameters in the framework: the number of generated seeds r, the number of new candidatesk2 and the number of selections k in ... have lots of labeleddata in another related domain. The frame-work is twofold. In the ﬁrst step, we gener-ate a few high-conﬁdence sentiment and topicseeds in the target domain. In the secondstep,...

Báo cáo khoa học: Amyloid oligomers: spectroscopic characterization of amyloidogenic protein states docx

... systems,including amyloid-beta protein, prion protein, transthyretin, a-synuclein,apolipoprotein C-II and insulin. To obtain information on the progression of the intermediate states, these were ... composed of the SH3 domain of PI3 kinase [42,43]. By mixing theselabelled proteins in a 50 : 50 ratio and following the aggregation process, their data revealed that the for-mation of oligomeric ... property of amyloidogenic oligomers, atleast in cell culture. Studies of the above-mentionedproteins and of other proteins linked to human amy-loidoses, including lysozyme [11] and prion protein[12],...

Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt

... Ca2+.Removing the proposed Ca2+-coordinating residues in positions 1 and 3 of the EF-hand motif signiﬁcantlycompromised the metal-binding capability of the engi-neered protein, indicating that the ... grafting approach to address thisquestion. As shown in Fig. 1B, the distance between the two termini of the inserted Ca2+-binding sites in the model structure of the EF-hand of STIM1 is within15 ... the initial mixture. The ﬂuorescence intensity wasnormalized by subtracting the contribution of the baselineslope using logarithmic ﬁtting. The Tb3+-binding afﬁnity of the protein was obtained...

Báo cáo khoa học: "Bilingual Hebrew-English Generation of Possessives and Partitives: Raising the Input Abstraction Level" pptx

... amount of the thing. The main modifications from the existing SURGE input structure are the introduction of the re/-set feature and the update of the usage of the possessor feature. For both of ... in the resulting sample: the selection of the unmarked realization option and the deter- mination of the default value of the definite feature remain difficult and vary a lot be- tween the ... defines the thing or set referred to by the NP • Qualifying: adds information to the thing • Identifying: identifies the thing among other possible referents • Quantifying: determines the...

Báo cáo khoa học: Kinetic hybrid models composed of mechanistic and simpliﬁed enzymatic rate laws – a promising method for speeding up the kinetic modelling of complex metabolic networks pptx

... through the individual reactions and the concentration values of the respective reactants are beingmeasured within the intact network operating in its cellularenvironment (i.e. either in the intact ... meta-bolites that mainly determine the integrity of the cell. The goodness of these simpliﬁed models was evaluatedby using the solutions of the full mechanistic model as the reference standard. In most ... constant and k the catalytic constant of the subject enzyme, and v the ﬂux of the reaction. The empirical parameters ai and bihave different meanings in the PL, LL and MM rate laws. The notation of...

Báo cáo khoa học: "Maximum Expected BLEU Training of Phrase and Lexicon Translation Models" pptx

... BLEU scores as the objective. This avoids the heuristics of picking the updating reference and therefore gives a more principal way of setting the training objective. As another closely related ... training of each other, we train them in alternation. I.e., at each iteration, we first fix λ and update θ, then we re-tune λ given the new θ. Due to mismatch between training and tuning ... tuning data, the training process might not always converge. Therefore, we need a validation set to determine the stop point of training. At the end, θ and λ that give the best score on the validation...

Báo cáo khoa học: "Beyond Projectivity: Multilingual Evaluation of Constraints and Measures on Non-Projective Structures" doc

... edges, combining lev-els of nodes with the partitioning of gaps of non-projective edges into components. We derive a for-mal property of these signatures that links them to the constraint of well-nestedness, ... 1998)—there it is deﬁned as the maximum over gap degrees of all subtrees of a dependency tree (the gap degree of a subtree is the number of contiguous intervals in the gap of the subtree). The interval ... corre-sponding constraints and violate all preceding ones)4.2 Edge measures The ﬁrst two measures are based on two ways of partitioning the gap of a non-projective edge—intointervals and into components....

Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka pptx

... including the stress response and food intake, are described.Expression of relaxin-3 in the brainRelaxin-3 neurons in the brainExamination of relaxin-3 mRNA expression by north-ern blotting ... expressed in the brain and testis. In rodent brain, ana-tomical studies have revealed its predominant expression in neurons of the nucleus incertus of the dorsal pons, and a few other regions of the ... brain-stem. On the other hand, relaxin-3-expressing nerve ﬁbers and the relaxin-3receptors, RXFP3 and RXFP1, are widely distributed in the forebrain,with the hypothalamus being one of the...

Báo cáo khoa học: Vibrio cholerae hemolysin Implication of amphiphilicity and lipid-induced conformational change for its pore-forming activity ppt

... monitored accumulation of the toxin at the interface of water and chloroform. The ratio of the aqueous phase concentration of the HlyA followingpartitioning with chloroform, c to the initial value, ... association of the protein in water, asindicated by light-scattering (Fig. 2) and gel ﬁltrationexperiments. Furthermore, the complex of the HlyA withasialofetuin, a glycoprotein inhibitor of the interaction ... absorption of the protein. The intrinsic Trp ﬂuorescence of the HlyA wasmonitored in buffer A by exciting the sample at 295 nmusing band widths of 2.5 nm. Lipid-induced perturbation of the conformation...

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