Báo cáo khoa học: Expression level and agonist-binding affect the turnover, ubiquitination and complex formation of peroxisome proliferator activated receptor b pptx

... Expression < /b> level < /b> and < /b> agonist-binding < /b> affect < /b> the < /b> turnover, < /b> ubiquitination < /b> and < /b> complex < /b> formation < /b> of < /b> peroxisome < /b> proliferator < /b> activated < /b> receptor < /b> b Markus Rieck*, Lena Wedeken*, Sabine Mu ¨ ller-Bru ¨ sselbach, ... stoichiometical amounts of < /b> the < /b> obligatory PPARb dimerizat...

Ngày tải lên: 30/03/2014, 03:20

... of < /b> the < /b> arginine is stabilized by a number of < /b> hydrogen bonds to the < /b> Na + -binding ligands (oxygen atoms of < /b> cE65, cV63 and < /b> cQ32). These hydrogen bonds minimize the < /b> polarity of < /b> the < /b> arginine in the < /b> hydrophobic ... the < /b> influence of < /b> the < /b> stator arginine on the < /b> conformational changes of < /b> the < /b>...

Ngày tải lên: 16/03/2014, 06:20

... of < /b> the < /b> solubilization of < /b> SugE, YfiK and < /b> TehA in micelles and < /b> of < /b> their reconstitution into membranes. The < /b> dissolving of < /b> the < /b> proteins in suitable detergents obviously resulted in the < /b> refolding of < /b> ... related to the < /b> number of < /b> transmembrane domains, and < /b> the < /b> cell-free expression < /b> of < /b>...

Ngày tải lên: 30/03/2014, 13:20

... conditions. Taken together, these findings may improve understanding of < /b> the < /b> cellu- lar and < /b> molecular basis of < /b> the < /b> anti-inflammatory and < /b> paracrine effects of < /b> mesenchymal cells. Abbreviations BrdU, 5-bromodeoxyuridine; ... NF-jB-dependent IL- 1b and < /b> TNF-a transcription Because transcription of < /b> IL- 1b and < /b> TNF-a can be aug- men...

Ngày tải lên: 18/02/2014, 04:20

... neither autophagy nor metabolism could be the < /b> primary cause of < /b> the < /b> loss of < /b> fermentative capacity. Rather, a subtle interplay between the < /b> two was observed from the < /b> beginning. The < /b> diversity of < /b> ... understand the < /b> patterns of < /b> enzyme capacities over time, we should rather consider them as the < /b> result of < /b> a balance b...

Ngày tải lên: 18/02/2014, 06:20

... 2C, the < /b> mRNA for Noxo1c was expressed substantially in the < /b> testis but only slightly in the < /b> colon. On the < /b> other hand, the < /b> Noxo 1b mRNA was relatively abundant in the < /b> colon and < /b> also present in the < /b> ... using the < /b> primers ‘d’ and < /b> ‘c’, where the < /b> cDNAs for both Noxo 1b and < /b> Noxo1c are amplified as the < /b> insert...

Ngày tải lên: 19/02/2014, 06:20

... document t, we can cal- culate the < /b> likelihood ratio between the < /b> probability given by the < /b> model for class c and < /b> the < /b> probabilities given by the < /b> other models for the < /b> other classes: LR = P (t|c)P (c)  c  =c P ... indicates the < /b> percentage of < /b> the < /b> total number of < /b> relevant documents in the < /b> data set that are retriev...

Ngày tải lên: 20/02/2014, 15:20

... reduce the < /b> availability of < /b> ACh and < /b> would therefore impair cholinergic responses. The < /b> origin of < /b> pRCC in the < /b> tubular epithe- lium [54] and < /b> the < /b> presence in it of < /b> muscarinic and < /b> nicotinic receptors ... effect of < /b> the < /b> transformed cell pheno- type, but the < /b> binding of < /b> the < /b> cytotoxic cisplatin to ac...

Ngày tải lên: 06/03/2014, 22:21

... lacks VWC and < /b> TSP module-coding ex- ons and < /b> part of < /b> the < /b> IGFBP module-coding exon. Because the < /b> alternative splicing site in IGFBP is located slightly upstream of < /b> the < /b> authentic site, the < /b> IG- FBP-coding ... constitutive expression < /b> of < /b> the < /b> full-length and < /b> the < /b> differentiation stage-dependent expression < /b>...

Ngày tải lên: 07/03/2014, 10:20

... efficient nucleophilic attack of < /b> the < /b> substrate ester bond by the < /b> serine alcoholate. The < /b> shape of < /b> the < /b> titration curve of < /b> the < /b> catalytic histidine shows an apparent pKa value of < /b> the < /b> essential histidine ... located within the < /b> Ônucleophilic elbowÕ connecting strand b5 and < /b> helix a3, while His290 and < /b> Asp260 e...

Ngày tải lên: 07/03/2014, 16:20