Báo cáo khoa học: Secondary structure conversions of Alzheimer’s Ab(1–40) peptide induced by membrane-mimicking detergents pdf

... secondary structures A. Wahlstro ¨ m et al. 5128 FEBS Journal 275 (2008) 5117–5128 ª 2008 The Authors Journal compilation ª 2008 FEBS Secondary structure conversions of Alzheimer’s Ab(1–40) peptide ... structural transitions of the Ab(1–40) peptide (75 lm) induced by increasing concentrations of the membrane-mimicking detergent LiDS. The 1 H- 15 N HSQC spectrum...

Ngày tải lên: 30/03/2014, 02:20

... gp130 peptide. Experiments were performed at 298 K. Solutions of 10– 25 lm SOCS3 in the cell were titrated by injection of a total of 290 lL of 80–200 lm of the gp130 peptide. The heat of dilution ... of the secondary structure and cor- rect domain boundaries of SOCS3 will enable manipu- lation of SOCS3 function by rational mutagenesis. This includes mutagenesis...

Ngày tải lên: 16/03/2014, 14:20

... is easier to compare the corresponding number of amino acids, instead of the percentages of secondary structure. Overall, the secondary structures of truncated and lipidated Ras are in very good ... that the X-ray structure deviates by up to 6% from the NMR structure. In particular, the random coil content of the NMR structure increases by 10 amino acids as compared to...

Ngày tải lên: 07/03/2014, 04:20

... question of structural organization and stability of the peptides. The increasing number of protein- ase inhibitor structures solved by NMR allows us to compare the structural organization of the ... the question of the universal nature of serine proteinase structure a mong animals a nd particularly, mechanism of inhibition by natural protein inhibitors. In the light of...

Ngày tải lên: 08/03/2014, 10:20

... spe- cific types of part-whole relations (member -of, sub-quantity -of, contained-in, structural part -of and located-in), and for the general set composed of all types. 4.1 Precision of Extracted Relations Two ... are manifested by a wide variety of specialized patterns (sub-quantity- of, structural part -of, and located-in for English, and located-in and member -of for Dutch)....

Ngày tải lên: 20/02/2014, 04:20

... the beginning and ending of the target chunk respectively. p i is the part of speech tag of w i and sc i is the shallow parse result of w i . Feature Name description of features Non-Chunk Features Word/POS/SC ... bound length of entities, N is the length of sentence and K is the size of label set. And that of training in first order semi-CRFs is O(K 2 LN). The increase of...

Ngày tải lên: 20/02/2014, 12:20

... complex language. 1 The morphological analysis of a word consists of determining the values of a large number of (or- thogonal) features, such as basic part -of- speech (i.e., noun, verb, and so on), ... (including part -of- speech tagging) are the same operation, which consists of three phases. First, we obtain from our morphological analyzer a list of all possible analyses for t...

Ngày tải lên: 20/02/2014, 15:20

... inhibition of NAT1 is caused by irreversible reaction with the active site cysteine residue. Kinetic analysis of the DS-dependent inhibition of NAT1 We further analysed the inhibition of NAT1 by DS by carrying ... for the inhibition of NAT1 by DS (k i ) was deduced from the slope of k obs as a function of the DS concentration [DS], and was 6 · 10 4 m )1 Æmin )1 . The ord...

Ngày tải lên: 07/03/2014, 02:20

... Beyreuther, K. (1999) Mechanism of the cleavage specificty of alzheimer’s disease c-secretase identified by phenylalanine-scan- ning mutagenesis of the transmembrane domain of the amyloid precursor protein. ... Allsop, D. (1999) Alzheimer’s disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like...

Ngày tải lên: 08/03/2014, 08:20

... acid or glucose [5]. For most of t he jasmonates it h as been shown that t hey are capable of mediating a response by regulating gene expression [6,7]. Analysis of Arabidopsis thaliana mutants impaired ... has been speculated that the physical role of MeJA is to mobilize JA [ 19]. The proof of this hypothesis might come from a more detailed understanding of how plants form MeJA...

Ngày tải lên: 16/03/2014, 18:20