Báo cáo khoa học: Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts docx

... Representatives of this class include certain amino acids (e.g. proline and glycine) and polyols (e.g. trehalose, sucrose and sorbitol). Counteracting osmolytes consist of the methylamine class of osmolytes, ... and amino acids and derivatives (glycine, alanine, proline, serine, lysine, b-alanine and taurine) that have no significant effects on both DG D ° and k cat . (b) C...

Ngày tải lên: 07/03/2014, 00:20

... thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts Miriam Frangini 1 , Chiara Rampazzo 1 , Elisa Franzolin 1 , Mari-Carmen Lara 2 , Maya ... caus- ing an imbalance of the dNTP pools as compared to the controls [17]. We determined the amounts of all four dNTPs in the cytosolic and mitochondrial po...

Ngày tải lên: 30/03/2014, 02:20

... & Kline DG (1997) Tumor necrosis factor-a and interleukin-1 induce activation of MAP kinase and SAP kinase in human neuroma fibroblasts. Neurochem Int 30, 401–410. 51 O’Neill LA & Greene ... the S100 family of Ca 2+ - binding proteins and are now accepted as markers of in ammation. They are expressed by keratinocytes and in ammatory cells in human ⁄ murine wo...

Ngày tải lên: 19/02/2014, 18:20

... have examined the putative protective or toxic effects of drugs interacting with cannabinoid receptors or have measured the brain levels of endocannabi- noids in in vitro and in vivo models of cerebral ... Cannabinoids promote oligodendrocyte progeni- tor survival: Involvement of cannabinoid receptors and phosphatidylinositol-3 kinase ⁄ Akt signaling. J Neurosci 22, 9742–975...

Ngày tải lên: 07/03/2014, 03:20

... of the wild-type protein. However, the intro- duction of a hydroxyl group in the heme pocket, and the increased van der Waals’ and electrostatic interactions between the side chain of Tyr35 and ... RTE-5B circulating bath instrument. The reaction was initiated by rapidly mixing equal volumes of solutions containing cyt b 5 and apo-Mb in a tandem mixing cell with path lengt...

Ngày tải lên: 08/03/2014, 10:20

... positioning of the ligands and the conformations of the residues lining the binding site (Table 2). In an initial comparison of the ligand positions of tetracycline, dox and atc in TetR, these ligands ... increased coordinate errors during the refinement of the atomic positions and hence a less accurate ligand positioning in site II. Accordingly, the description of the...

Ngày tải lên: 16/03/2014, 00:20

... Synoviolin increases the mem- brane localization of huntingtin protein [18], also sug- gesting that Synoviolin is involved in intracellular trafficking. We also found that NCT interacts with Synoviolin (Fig. ... Synoviolin is involved in the degradation of PS cofactors using syno- violin-null cells, as PS cofactors undergo the ubiqui- tin ⁄ proteasome pathway. We report that Synoviolin...

Ngày tải lên: 23/03/2014, 04:20

... and plural. Finally, the tagged instances are stored in a file with their surrounding words. Each line of it con- sists of one of the tagged instances and its sur- rounding words as in the above ... performance of the proposed method will improve if these instances are included in the training data. the target errors since they are based on the articles and the distinction...

Ngày tải lên: 23/03/2014, 18:20

... protein–protein interactions induce changes in proximity relationships of Cys48 and Cys64 in chicken skeletal troponin I Ying-Ming Liou and Ming-Wei Chen Department of Life Science, Institute of ... R.S. (1997) Mapping of a second actin-tropomyosin and a second troponin C binding site within the C terminus of troponin I, and their importance in the Ca 2+ -dependent reg...

Ngày tải lên: 23/03/2014, 21:20

... having a C-terminal kinase catalytic domain, preceded by Src homology 2 and -3 protein interaction domains that are important for kinase regulation, and a Tec homology domain containing one or two ... membrane. In the case of Itk and Tec, recruitment is mediated by binding of phosphatidylinositol (3,4,5) -triphosphate, the product of phosphatidylinositol 3 -kinase, to the...

Ngày tải lên: 28/03/2014, 22:21