Báo cáo khoa học: Impact of cyclic hypoxia on HIF-1a regulation in endothelial cells – new insights for anti-tumor treatments doc

... effects on HIF-1a during cyclic hypoxia; caution is therefore required in the use of NOS inhibitors as single anti-tumor treatments. More generally, by providing new insights into the regula- tion of ... activation (through phosphorylation on serine 1177) and the consequent NO-mediated angiogenesis [32,33]. In conclusion, this study offers new insights into the im...

Ngày tải lên: 30/03/2014, 02:20

... Monitoring, drug monitoring error; Others, errors in posology, concentration, contra-indication. Available online http://ccforum.com/content/10/1/R21 Page 7 of 9 (page number not for citation ... continuous infusion prescriptions (for example, propofol or remifentanil infusion being still activated two days post extubation). Another example of intercepted MPE involved the wrong presc...

Ngày tải lên: 25/10/2012, 10:39

... Investiga- tions of the effect of thermostability on protein secre- tion and aggregation have also been performed in other organisms including Escherichia coli, and in mamma- lian cells [4 0–4 2]. In some instances, ... Quantification of relative mRNA expression in the rat brain using simple RT-PCR and ethidium bromide staining. J Neurosci Methods 99, 4 5–5 1. 31 Engelhar...

Ngày tải lên: 19/02/2014, 08:20

... problem solving. Before embarking on an exhaustive man- ual annotation of initiative, I chose to get a sense of whether initiative may indeed affect learning in this context by automatically tagging for ... crossing-out lines and inserting lines, as well as undoing these corrections. 3. Chat Area: Allows for user input and an inter- leaved dialogue history of both students parti...

Ngày tải lên: 31/03/2014, 00:20

... various interacting components. The formation of dopamine–quinone adducts (because of auto-oxidation of the neurotrans- mitter), especially dopaminochrome, with a-synuclein, inhibited the conversion ... intensified. This confirmed the formation of SDS-insoluble aggregates of a-synuclein on incubation. Effect of MPTP and MPP + on the aggregation pattern of a-synuclein a-Synucle...

Ngày tải lên: 14/02/2014, 19:20

... copper- binding sites (in D1 and D2), acquired a T2–T3 cluster binding site (the dioxygen reduction site mapping at the boundary of D1 and D3) and substrate-binding sites (one for the electron donor ... artificial catalysts performing new activities. In a first approach, basic protein engineering techniques – such as fusion of laccase with an interacting domain [23] – were us...

Ngày tải lên: 18/02/2014, 06:20

... expression, whereas the II-11b cells main- tained low S100A4 expression (Fig. 2B). As shown in Fig. 2B, equal amounts of protein were loaded based on equal amounts of actin. Binding of cells to ... pHb-1 cells containing a high level of MT1-MMP [18] or with a commercial recom- binant soluble form of MT1-MMP containing only the catalytic domain. As shown in Fig. 7, both t...

Ngày tải lên: 18/02/2014, 11:20

... dimension. A sine function was applied in both dimensions of the time domain before Fourier transformation. Integration of 1D and 2D signals was performed using 1D winnmr and 2D winnmr software (Bruker, ... provide metabolic information on tumour cell metabolism, aiming for increased knowledge for use in anti-cancer treatments. Accordingly, the presence of intense lipid signa...

Ngày tải lên: 18/02/2014, 13:20

... role in the reactivation of TRAIL-induced apoptosis after proteasome inhibition in glioma cells. CHOP is not involved in DR5 upregulation by PIs and cell death induced by proteasome inhibition plus ... DR5 knockdown, indicating that basal expression of DR5 is required for the TRAIL sensitivity in these cells. Apoptosis induced by TRAIL in combination Fig. 2. Reactivation o...

Ngày tải lên: 18/02/2014, 17:20

... leading to a reduction in ATP. Because heart mitochondria from iNOS – ⁄ – Fig. 6. Changes in mitochondrial ATP production in heart of iNOS + ⁄ + and iNOS – ⁄ – mice, using succinate as substrate. ... utilized to determinate P i concentration [67]. ATPase activity was expressed in nmoL P i Æmin )1 Æmg protein )1 . Determination of ATP production For the determinat...

Ngày tải lên: 19/02/2014, 00:20