Báo cáo khoa học: Mutagenic probes of the role of Ser209 on the cavity shaping loop of human monoamine oxidase A docx

... Comparison of competitive inhibition constants [K i (lM)] for purified wild-type human MAO A and human MAO A Ser209Ala and Ser209Glu mutants. Human MAO A Human MAO A Ser209Ala Human MAO A Ser209Glu D-Amphetamine ... ª 2009 The Authors Journal compilation ª 2009 FEBS 4581 Mutagenic probes of the role of Ser209 on the cavity shaping loop of huma...

Ngày tải lên: 30/03/2014, 01:20

... Biotech, Auburn, CA, USA). All research mice at CINVESTAV and Trudeau Institute were eutha- nized by CO 2 narcosis in accordance with the recommenda- tions of the Panel on Euthanasia of the AVMA and ... however, the structural requirements for their stabilization on the plasma mem- brane are unknown. We demonstrate that the majority of CD38 is assembled as noncovalently...

Ngày tải lên: 23/03/2014, 12:20

... reversible. The loss of activity, on stor- age, of some preparations of the enzyme after activation could be traced to the presence of a contaminating phosphatase activity in these preparations. The addition of ... irreversibility of the thermal melting prevents evaluation of the free energies of the activated and unactivated states. Both unactivated and acti...

Ngày tải lên: 16/03/2014, 18:20

... mori Naoki Okamoto 1 , Naoki Yamanaka 2, *, Honoo Satake 3 , Hironao Saegusa 1, , Hiroshi Kataoka 2 and Akira Mizoguchi 1 1 Division of Biological Science, Graduate School of Science, Nagoya University, ... Nagasawa H, Kataoka H, Isogai A, Tamura S, Suzuki A, Fujino M & Kitada C (1987) A monoclonal antibody against a synthetic frag- ment of bombyxin (4K-prothoracicotropic hor...

Ngày tải lên: 18/02/2014, 13:20

... 3926–3931. 13 Johansson M, Van Rompay AR, Degreve B, Balzarini J & Karlsson A (1999) Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Droso- phila melanogaster. J ... Exclu- sive labeling of mitochondrial deoxyribonucleic acid. J Biol Chem 248, 2722–2729. 6 Davis AF & Clayton DA (1996) In situ localization of mitochondrial DNA replication in...

Ngày tải lên: 20/02/2014, 01:20

... information redundancy can be used as a measure of the redundancy between the predictive information of a feature type and that of a feature type combination. Predictive Information Summation ... evaluation model for statistical syntactic parsing Given a sentence, the task of statistical syntactic parsing is to assign a probability to each candidate parsing tree that...

Ngày tải lên: 20/02/2014, 18:20

... effect on mito- chondrial respirations of peritoneal macrophages after 2 h of treatment. Effect of MDP on cell viability The viability of peritoneal macrophages under condi- tions of maximum impairment ... peritoneal macrophages was determined by Griess assay. The NO concentration of the culture supernatant was significantly increased after stimulation with Table 1. Effec...

Ngày tải lên: 05/03/2014, 23:20

... were also obtained from Sigma. These and other chemicals, which were of analytical grade, were used without further purification. Dialysis and the determination of the concentration of protein An ... Dar TA, Haque I, Anjum F, Moosavi- Movahedi AA & Ahmad F (2007) Testing the paradigm that the denaturing effect of urea on protein stability is offset by methylamines at the...

Ngày tải lên: 07/03/2014, 00:20

... animal species and in other aromatic amino acid hydroxylases [19]. TH activity is subject to intri- cate regulation. Transcriptional control, modulation of RNA stability, translational regulation ... presence of NMNorsal and Norsal (Fig. 5A) . DA is an unstable neurotransmitter (Fig. 5B). Its autoxidation leads to the formation of DA quinone and is accompanied by the generation of...

Ngày tải lên: 07/03/2014, 05:20

... handling the gapping data, since the infelicity of gapping in non-parallel constructions hinged on there no longer being a propositional representation available as a source. 16In addition, ... istic that Common Topic relations share is that they require the identification of parallel entities (i.e., the al and bi) and relations (P0 and Px) as arguments to the co...

Ngày tải lên: 08/03/2014, 07:20